Big endothelin‐1 structure important for specific processing by endothelin‐converting enzyme of bovine endothelial cells

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

New coupling reagents in peptide chemistry

1989 • 970 citations

The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase).

1990 • 247 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1

1990 • 158 citations

Inhibition of biological actions of big endothelin-1 by phosphoramidon

1990 • 146 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

cDNA cloning and chromosomal assignment of the endothelin 2 gene: Vasoactive intestinal contractor peptide is rat endothelin 2

1991 • 120 citations

Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance.

1990 • 118 citations

Conversion of big endothelin‐1 to endothelin‐1 by two types of metalloproteinases derived from porcine aortic endothelial cells

1990 • 112 citations

Identification and characterization of endothelin converting activity in cultured bovine endothelial cells

1990 • 92 citations

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

1989 • 81 citations

Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells

1991 • 78 citations

Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: Evidence for a cathepsin D-like enzyme

1990 • 69 citations

Generation of human endothelin by cathepsin E

1990 • 68 citations

One of the endothelin gene family, endothelin 3 gene, is expressed in the placenta

1990 • 58 citations

Phosphoramidon-sensitive endothelin-converting enzyme in the cytosol of cultured bovine endothelial cells

1991 • 43 citations

Different pharmacological profiles of big‐endothelin‐3 and big‐endothelin‐1 in vivo and in vitro

1991 • 41 citations

Characterization of endothelin converting enzyme in rat lung

1990 • 34 citations

In vitro and in vivo activity of chymotrypsin-activated big endothelin (porcine 1–40)

1989 • 33 citations

Presence of a phosphoramidon-sensitive endothelin-converting enzyme which converts big-endothelin-1, but not big-endothelin-3, in the rat vas deferens

1991 • 32 citations

In vitro degradation of endothelin-1 by endopeptidase 24.11 (enkephalinase)

1991 • 30 citations

Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane

1993 • 29 citations

Phosphoramidon‐sensitive endothelin‐converting enzyme in vascular endothelial cells converts big endothelin‐1 and big endothelin‐3 to their mature form

1992 • 29 citations

Mode of cleavage of pig big endothelin-1 by chymotrypsin. Production and degradation of mature endothelin-1

1990 • 29 citations

Pepsin, an aspartic protease, converts porcine big endothelin to 21-residue endothelin

1990 • 28 citations

Importance of the C-terminal region of big endothelin-1 for specific conversion by phosphoramidon-sensitive endothelin converting enzyme

1991 • 28 citations

Local formation and degradation of endothelin-1 in guinea pig airway tissues

1991 • 22 citations

Phosphoramidon-sensitive effects of big endothelins in the perfused rabbit kidney.

1992 • 20 citations

Biochemical properties of endothelin converting enzyme in renal epithelial cell lines

1992 • 17 citations

Coeliac haemodynamic effects of endothelin‐1, endothelin‐3, proendothelin‐1 [1–38] and proendothelin‐3 [1–41] in conscious rats

1992 • 16 citations

Inhibition by phosphoramidon of the regional haemodynamic effects of proendothelin−2 and −3 in conscious rats

1992 • 15 citations

Identification and Partial Purification of a Thiol Endothelin- Converting Enzyme from Porcine Aortic Endothelial Cells

1992 • 14 citations

Big endothelin-3-induced hypertension and its inhibition by phosphoramidon in anaesthetized rats

1993 • 11 citations

Effect of phosphoramidon on big endothelin‐2 conversion into endothelin‐2 in human renal adenocarcinoma (ACHN) cells Analysis of endothelin‐2 biosynthetic pathway

1992 • 11 citations

Detection by Bioassay and Specific Enzyme-Linked Immunosorbent Assay of Phosphoramidon-Inhibitable Endothelin-Converting Activity in Brain and Endothelium

1992 • 7 citations

Characterization and Partial Purification of Endothelin-Converting Enzyme in Rat Lung

1991 • 4 citations