Phosphoramidon-sensitive effects of big endothelins in the perfused rabbit kidney.

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

1988 • 1,417 citations

Integrated cardiac, renal, and endocrine actions of endothelin.

1989 • 481 citations

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

1988 • 400 citations

A radioimmunoassay for 6-keto- prostaglandin F1α

1978 • 319 citations

Endothelin: a potent renal and systemic vasoconstrictor peptide

1989 • 232 citations

cDNA cloning and chromosomal assignment of the gene encoding endothelin 3

1989 • 167 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1

1990 • 158 citations

Inhibition of biological actions of big endothelin-1 by phosphoramidon

1990 • 146 citations

Conversion of big endothelin-1 by membrane-bound matalloendopeptidase in cultured bovine endothelial cells

1990 • 132 citations

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

1989 • 126 citations

Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin-2 gene (EDN2) to 1p34, and the endothelin-3 gene (EDN3) to 20q13.2-q13.3.

1991 • 109 citations

Endothelin-1 Releases Eicosanoids from Rabbit Isolated Perfused Kidney and Spleen

1989 • 88 citations

Endothelin-1 Releases Prostacyclin and Inhibits ex vivo Platelet Aggregation in the Anesthetized Rabbit

1989 • 75 citations

Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit

1990 • 54 citations

Human big‐endothelin‐1 and endothelin‐1 release prostacyclin via the activation of ET₁ receptors in the rat perfused lung

1992 • 50 citations

Renal actions of endothelin: interaction with prostacyclin

1990 • 45 citations

Different pharmacological profiles of big‐endothelin‐3 and big‐endothelin‐1 in vivo and in vitro

1991 • 41 citations

VASCULAR ACTIONS OF ENDOTHELIN IN THE RABBIT KIDNEY

1990 • 39 citations

Presence of a phosphoramidon-sensitive endothelin-converting enzyme which converts big-endothelin-1, but not big-endothelin-3, in the rat vas deferens

1991 • 32 citations

Human Big Endothelin Releases Prostacyclin in vivo and in vitro Through a Phosphoramidon-Sensitive Conversion to Endothelin-1

1991 • 26 citations

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