Mode of cleavage of pig big endothelin-1 by chymotrypsin. Production and degradation of mature endothelin-1

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Formation of endothelin by cultured airway epithelial cells

1989 • 180 citations

Regional distribution of immunoreactive endothelin in porcine tissue: Abundance in inner medulla of kidney

1989 • 164 citations

Conversion of porcine big endothelin to endothelin by an extract from the porcine aortic endothelial cells

1990 • 100 citations

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: Evidence for biosynthetic pathway of endothelin-1

1989 • 81 citations

Secretion of endothelin and related peptides from renal epithelial cell lines

1989 • 79 citations

Concomitant secretion of big endothelin and its C-terminal fragment from human and bovine endothelial cells

1989 • 57 citations

Production of Endothelin-1 and Big-Endothelin-1 by Tumor Cells with Epithelial-Like Morphology

1989 • 56 citations

In vitro and in vivo activity of chymotrypsin-activated big endothelin (porcine 1–40)

1989 • 33 citations

Pepsin, an aspartic protease, converts porcine big endothelin to 21-residue endothelin

1990 • 28 citations