To kill or to cure: options in host defense against viral infection

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Tumour necrosis factors α and β inhibit virus replication and synergize with interferons

1986 • 726 citations

High-level hepatitis B virus replication in transgenic mice

1995 • 625 citations

Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

1995 • 474 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Antiviral effects of recombinant tumour necrosis factor in vitro

1986 • 392 citations

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

1995 • 369 citations

Immunobiology and Pathogenesis of Hepatocellular Injury in Hepatitis B Virus Transgenic Mice

1990 • 363 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

Encoding of a Homolog of the IFN-γ Receptor by Myxoma Virus

1992 • 303 citations

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection.

1996 • 299 citations

Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity

1995 • 295 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus.

1983 • 247 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.

1996 • 199 citations

Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.

1994 • 199 citations

Rapid resolution of duck hepatitis B virus infections occurs after massive hepatocellular involvement

1992 • 188 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

1995 • 179 citations

Inhibition of human immunodeficiency virus replication in acutely infected CD4+ cells by CD8+ cells involves a noncytotoxic mechanism

1991 • 173 citations

CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

1989 • 169 citations

Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA.

1991 • 163 citations

Woodchuck hepatitis virus infections: very rapid recovery after a prolonged viremia and infection of virtually every hepatocyte

1994 • 154 citations

Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.

1991 • 145 citations

Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice

1992 • 145 citations

Interleukin-2 and alpha/beta interferon down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor-dependent and -independent pathways

1994 • 140 citations

Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice.

1995 • 139 citations

Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte-activated hepatocytes.

1995 • 124 citations

Inhibition of vesicular stomatitis virus mRNA synthesis by human MxA protein

1991 • 119 citations

Role of Hepatitis C and Delta Viruses in the Termination of Chronic Hepatitis B Surface Antigen Carrier State: A Multivariate Analysis in a Longitudinal Follow-up Study

1994 • 119 citations

Immunodeficient mice recover from infection with vaccinia virus expressing interferon‐γ

1990 • 117 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr, and Bcl-2-transgenic mice.

1995 • 116 citations

Gamma interferon is a major mediator of antiviral defense in experimental measles virus-induced encephalitis

1995 • 115 citations

Local production of tumor necrosis factor encoded by recombinant vaccinia virus is effective in controlling viral replication in vivo.

1991 • 93 citations

Interruption of cytokine networks by poxviruses: lessons from myxoma virus

1995 • 91 citations

Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium

1996 • 89 citations

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

1994 • 89 citations

In Vivo Protective Effect of Tumour Necrosis Factor Against Experimental Infection with Herpes Simplex Virus Type 1

1991 • 84 citations

Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice.

1995 • 80 citations

Immune therapy of a persistent and disseminated viral infection

1987 • 77 citations

Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism

1993 • 75 citations

Viral infection of the thymus

1992 • 65 citations

The Myxoma Virus TNF-Receptor Homologue (T2) Inhibits Tumor Necrosis Factor-α in a Species-Specific Fashion

1994 • 64 citations

Studies on the role of the 2'-5'-oligoadenylate synthetase-RNase L pathway in beta interferon-mediated inhibition of encephalomyocarditis virus replication

1988 • 61 citations

Acute type A hepatitis during chronic hepatitis B virus infection: Association of depressed hepatitis B virus replication with appearance of endogenous alpha interferon

1984 • 57 citations

Cytokine regulation by virus infection: bovine viral diarrhea virus, a flavivirus, downregulates production of tumor necrosis factor alpha in macrophages in vitro

1996 • 56 citations

Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope.

1992 • 39 citations

Peroxidase‐anti‐peroxidase detection of hepatitis B surface and core antigen in liver biopsy specimens from patients with chronic type B hepatitis

1987 • 29 citations

Murine hepatitis caused by lymphocytic choriomeningitis virus. I. The hepatic lesions.

1994 • 29 citations

Acute viral hepatitis: Morphologic and functional correlations in human livers

1984 • 24 citations

Elusive HIV-Suppressor Factors Found

1995 • 11 citations