Tumor necrosis factor alpha negatively regulates hepatitis B virus gene expression in transgenic mice

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family

1985 • 2,145 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

1990 • 642 citations

Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression.

1986 • 585 citations

A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia

1985 • 525 citations

Effects of cytokines on the liver

1991 • 409 citations

Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon.

1985 • 397 citations

Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma.

1985 • 356 citations

Regulation, linkage, and sequence of mouse metallothionein I and II genes.

1984 • 335 citations

The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene.

1988 • 295 citations

A Transgenic Mouse Model of the Chronic Hepatitis B Surface Antigen Carrier State

1985 • 281 citations

TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.

1989 • 275 citations

Interdependence of the radioprotective effects of human recombinant interleukin 1 alpha, tumor necrosis factor alpha, granulocyte colony-stimulating factor, and murine recombinant granulocyte-macrophage colony-stimulating factor.

1988 • 265 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Action of recombinant human interleukin 6, interleukin 1β and tumor necrosis factor α on the mRNA induction of acute‐phase proteins

1988 • 254 citations

Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts.

1988 • 241 citations

Endotoxin induction of murine metallothionein gene expression.

1990 • 239 citations

Antitumor activity of recombinant interleukin 6 in mice.

1990 • 230 citations

Multiple Cytokines Stimulate Hepatic Lipid Synthesisin Vivo*

1989 • 209 citations

Transcriptional regulation of serum amyloid A gene expression.

1986 • 188 citations

Transgenic mice with intracellular immunity to influenza virus

1990 • 187 citations

Relation of the hepatitis B virus carrier state to hepatocellular carcinoma

1987 • 186 citations

Cloning in Escherichia coli and physical structure of hepatitis B virion DNA.

1979 • 171 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Hepatic acute phase reaction in vivo and in vitro

1989 • 132 citations

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.

1990 • 121 citations

Leukotriene-mediated liver injury

1988 • 119 citations

Spontaneous production of tumour necrosis factor α and interleukin-1β during interferon-α treatment of chronic HBV infection

1990 • 101 citations

Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro.

1988 • 101 citations

Regulation, Linkage, and Sequence of Mouse Metallothionein I and II Genes

1984 • 96 citations

Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

1987 • 90 citations

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene

1991 • 86 citations

Modulation of murine natural killer cell activity in vitro and in vivo by recombinant human interferons.

1984 • 79 citations

Interferon inhibits hepatitis B virus replication in a stable expression system of transfected viral DNA

1989 • 76 citations

Transcriptional activation and repression by cellular DNA-binding protein C/EBP

1990 • 72 citations

Antitumor effects of alpha-interferon and gamma-interferon on a murine renal cancer (Renca) in vitro and in vivo.

1990 • 65 citations

Alpha interferon suppresses hepatitis B virus enhancer activity and reduces viral gene transcription

1990 • 58 citations

The mouse albumin enhancer contains a negative regulatory element that interacts with a novel DNA-binding protein.

1990 • 56 citations

Influence of chronic inflammation on the level of mRNA for acute-phase reactants in the mouse liver.

1986 • 48 citations

Developmental regulation of hepatitis B surface antigen expression in two lines of hepatitis B virus transgenic mice

1989 • 45 citations

Hierarchic and cooperative binding of the rat liver nuclear protein C/EBP at the hepatitis B virus enhancer.

1990 • 43 citations

Transcriptional regulation of acetyl coenzyme A carboxylase gene expression by tumor necrosis factor in 30A-5 preadipocytes.

1989 • 36 citations

Tumor necrosis factor/cachectin is a less potent inducer of serum amyloid A synthesis than interleukin 1.

1987 • 28 citations

The Mouse Albumin Enhancer Contains a Negative Regulatory Element That Interacts with a Novel DNA-Binding Protein

1990 • 21 citations

Hierarchic and Cooperative Binding of the Rat Liver Nuclear Protein C/EBP at the Hepatitis B Virus Enhancer

1990 • 17 citations

Direct modulation of HBV surface antigen in a human, HBsAg‐producing hepatocellular carcinoma cell line by alpha, beta, or gamma interferons

1990 • 10 citations

Transcriptional Regulation of Acetyl Coenzyme A Carboxylase Gene Expression by Tumor Necrosis Factor in 30A-5 Preadipocytes

1989 • 8 citations

Interleukin 6 is a negative regulator of the acute phase alpha 1-inhibitor III gene.

1990 • 7 citations

Interleukin 6 is a negative regulator of the acute phase alpha 1-inhibitor III gene.

1990 • 1 citations