The crystal structure of the catalytic domain of human urokinase-type plasminogen activator

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Sparse matrix sampling: a screening method for crystallization of proteins

1991 • 2,050 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

1989 • 889 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Stereochemical Criteria for Polypeptide and Protein Chain Conformations

1965 • 715 citations

Structural basis of the activation and action of trypsin

1978 • 669 citations

The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

1992 • 628 citations

Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.

1992 • 571 citations

Automatic indexing of rotation diffraction patterns

1988 • 552 citations

The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.

1987 • 479 citations

The refined crystal structure of bovine β-trypsin at 1·8 Å resolution

1975 • 462 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

Structure of Human Des(1-45) Factor Xa at 2·2 Å Resolution

1993 • 392 citations

Comparative modeling methods: Application to the family of the mammalian serine proteases

1990 • 383 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

1990 • 315 citations

The Primary Structure of High Molecular Mass Urokinase from Human Urine. The Complete Amino Arid Sequence of the A Chain

1982 • 312 citations

Three-dimensional Structure of Tosyl-elastase

1970 • 299 citations

Comparative model-building of the mammalian serine proteases

1981 • 286 citations

Structure of α-chymotrypsin refined at 1.68 Å resolution

1985 • 285 citations

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain.

1992 • 253 citations

The Complete Amino Acid Sequence of Low Molecular Mass Urokinase from Human Urine

1982 • 230 citations

The Receptor-Binding Sequence of Urokinase

1987 • 167 citations

Kinetics of inhibition of tissue‐type and urokinase‐type plasminogen activator by plasminogen‐activator inhibitor type 1 and type 2

1988 • 156 citations

Data Collection and Processing

1980 • 143 citations

Urokinase-type plasminogen activator and its receptor: new targets for anti-metastatic therapy?

1994 • 139 citations

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor.

1993 • 108 citations

Crystalline Human Urokinase: Some Properties

1965 • 108 citations

Structural Relationship between "Glutamic Acid" and "Lysine" Forms of Human Plasminogen and Their Interaction with the NH2-Terminal Activation Peptide as Studied by Affinity Chromatography

1975 • 101 citations

Solution Structure of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator

1994 • 86 citations

Converting Tissue Plasminogen Activator to a Zymogen: A Regulatory Triad of Asp-His-Ser

1993 • 86 citations

Structure of Human Factor D

1994 • 83 citations

A synthetic DNA encoding a modified human urokinase resistant to inhibition by serum plasminogen activator inhibitor

1991 • 67 citations

Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR

1989 • 62 citations

Human plasma fibronectin as a substrate for human urokinase

1989 • 58 citations

Urokinase-type plasminogen activator and malignancy

1993 • 56 citations

Purification and Characterization of Recombinant Urokinase from Escherichia coli

1985 • 54 citations

Domain structure and interactions of recombinant urokinase-type plasminogen activator.

1992 • 53 citations

Fibrinolytic properties of single chain urokinase-type plasminogen activator (Pro-urokinase)

1990 • 49 citations

Solution of a Fab (26-10)/digoxin complex by generalized molecular replacement

1991 • 39 citations

Activation of chymotrypsinogen-A

1973 • 34 citations

Backbone Dynamics of a Two-Domain Protein: 15N Relaxation Studies of the Amino-Terminal Fragment of Urokinase-Type Plasminogen Activator

1994 • 34 citations

New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue

1993 • 31 citations

Solution Structure of the Kringle Domain from Urokinase-type Plasminogen Activator

1994 • 31 citations

NMR studies of the dynamics of the multidomain protein urokinase-type plasminogen activator

1993 • 26 citations

Unfolding Studies of the Protease Domain of Urokinase-Type Plasminogen Activator: The Existence of Partly Folded States and Stable Subdomains

1994 • 15 citations

Mutations affecting the activity of urokinase-type plasminogen activator

1991 • 5 citations

Use of Berkeley Reactor Questioned on Military-Related Research

1987 • 3 citations