Accumulation of Mutant p53V143A Modulates the Growth, Clonogenicity, and Radiochemosensitivity of Malignant Glioma Cells Independent of Endogenous p53 Status

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Gain of function mutations in p53

1993 • 876 citations

Overexpression of the EGF Receptor and p53 Mutations are Mutually Exclusive in the Evolution of Primary and Secondary Glioblastomas

1996 • 733 citations

Clonal expansion of p53 mutant cells is associated with brain tumour progression

1992 • 687 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Tumors associated with p53 germline mutations: a synopsis of 91 families.

1997 • 409 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Analysis of the p53 gene and its expression in human glioblastoma cells.

1994 • 329 citations

A Mutant p53 That Discriminates between p53-Responsive Genes Cannot Induce Apoptosis

1996 • 283 citations

An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

1998 • 241 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

Comparative Study of p53 Gene and Protein Alterations in Human Astrocytic Tumors

1993 • 229 citations

Predicting response to cancer chemotherapy: the role of p53

1998 • 226 citations

The p53 gene and its role in human brain tumors

1995 • 188 citations

A tiger behind many doors: multiple genetic pathways to malignant glioma

1995 • 187 citations

Predicting chemoresistance in human malignant glioma cells: The role of molecular genetic analyses

1998 • 171 citations

The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood.

1997 • 144 citations

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

1998 • 138 citations

Loss of function and p53 protein stabilization

1997 • 135 citations

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

1991 • 131 citations

A temperature-sensitive mutant of human p53.

1994 • 128 citations

Accumulation of wild type p53 protein in human astrocytomas.

1993 • 127 citations

Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value

1997 • 125 citations

A Correlative Study of p53 Protein Alteration and p53 Gene Mutation in Glioblastoma Multiforme

1993 • 119 citations

Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance.

1996 • 108 citations

`Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

1998 • 88 citations

p53 and Brain Tumors: From Gene Mutations to Gene Therapy

1998 • 82 citations

Aberrant p53 expression in astrocytic neoplasms of the brain: association with proliferation.

1993 • 79 citations

Immortalization of human mammary epithelial cells transfected with mutant p53 (273his).

1996 • 72 citations

Prognostic Implications of p53 Overexpression in Supratentorial Astrocytic Tumors

1994 • 70 citations

Prognostic indicators in a range of astrocytic tumours: an immunohistochemical study with Ki-67 and p53 antibodies.

1995 • 65 citations

Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors

1998 • 55 citations

Prognostic significance of p53 immunoreactivity in patients with glioma.

1995 • 53 citations

Chemosensitivity of human malignant glioma: modulation by p53 gene transfer.

1998 • 48 citations

p53 immunohistochemical positivity as a prognostic marker in intracranial tumours

1994 • 32 citations

Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents

1998 • 29 citations

A new look at the role of p53 in leukemia cell sensitivity to chemotherapy

1997 • 25 citations

Prognostic Significance of p53 Immunoreactivity in Adult Patients with Supratentorial Fibrillary Astrocytic Neoplasms

1994 • 20 citations

Dominant‐negative p53 can restore tumorigenicity of L‐929 cells in immunocompetent mice

1995 • 10 citations

Suppression of tumorigenic and metastatic potentials of human melanoma cell lines by mutated (143 Val-Ala) p53

1998 • 6 citations