Mutation of the p53 gene in human astrocytic tumours correlates with increased resistance to DNA-damaging agents but not to anti-microtubule anti-cancer agents

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Randomized Comparisons of Radiotherapy and Nitrosoureas for the Treatment of Malignant Glioma after Surgery

1980 • 1,625 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Mechanism of action of taxol

1992 • 730 citations

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1996 • 654 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.

1996 • 382 citations

Pathways leading to glioblastoma multiforme: a molecular analysis of genetic alterations in 65 astrocytic tumors

1994 • 304 citations

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents.

1996 • 298 citations

Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis.

1991 • 165 citations

Salvage chemotherapy with paclitaxel for recurrent primary brain tumors.

1995 • 78 citations

Normal p53 status and function despite the development of drug resistance in human breast cancer cells.

1995 • 72 citations

Phase I study of weekly outpatient paclitaxel and concurrent cranial irradiation in adults with astrocytomas.

1996 • 61 citations

Weekly paclitaxel with and without concurrent radiation therapy: toxicity, pharmacokinetics, and response.

1996 • 26 citations

Prediction of Drug Cytotoxicity in 9L Rat Brain Tumor by Using Flow Cytometry with a Deoxyribonucleic Acid-binding Dye

1997 • 7 citations