ras p21 deletion mutants and monoclonal antibodies as tools for localization of regions relevant to p21 function.

Prediction of protein antigenic determinants from amino acid sequences.

1981 • 3,715 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus

1980 • 356 citations

ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae

1983 • 345 citations

The isolation of hybrid cell lines producing monoclonal antibodies against the p15(E) protein of ecotropic murine leukemia viruses

1979 • 324 citations

Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses

1979 • 315 citations

Primary structure of the α-subunit of transducin and its relationship to ras proteins

1985 • 291 citations

Sequence of the Alpha Subunit of Photoreceptor G Protein: Homologies Between Transducin, ras , and Elongation Factors

1985 • 276 citations

Developmental regulation of a dictyostelium gene encoding a protein homologous to mammalian ras protein

1984 • 267 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

1985 • 195 citations

Yeast and mammalian ras proteins have conserved biochemical properties

1985 • 195 citations

The drosophila ras oncogenes: Structure and nucleotide sequence

1984 • 175 citations

Versatile expression vectors for high-level synthesis of cloned gene products in Escherichia coli

1985 • 174 citations

GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence.

1985 • 169 citations

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21

1984 • 144 citations

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1982 • 135 citations

Regional homology in GTP-binding proto-oncogene products and elongation factors.

1983 • 123 citations

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells

1986 • 118 citations

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

1984 • 109 citations

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

1984 • 100 citations

Metabolic Turnover of Human c-ras^H p21 Protein of EJ Bladder Carcinoma and Its Normal Cellular and Viral Homologs

1984 • 92 citations

Effects of two major activating lesions on the structure and conformation of human ras oncogene products.

1985 • 83 citations

Viral Harvey ras p21 expressed in Escherichia coli purifies as a binary one-to-one complex with GDP.

1985 • 67 citations

Biochemical Properties of a Highly Purified v-ras^H p21 Protein Overproduced in Escherichia coli and Inhibition of Its Activities by a Monoclonal Antibody

1985 • 65 citations

Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding.

1985 • 63 citations

Monoclonal antibody Y13-259 recognizes an epitope of the p21 ras molecule not directly involved in the GTP-binding activity of the protein.

1986 • 49 citations

Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities.

1986 • 35 citations

Antibody of predetermined specificity to a carboxy-terminal region of H-ras gene products inhibits their guanine nucleotide-binding function.

1985 • 12 citations