Ha-ras proteins exhibit GTPase activity: point mutations that activate Ha-ras gene products result in decreased GTPase activity.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Elution of proteins from sodium dodecyl sulfate-polyacrylamide gels, removal of sodium dodecyl sulfate, and renaturation of enzymatic activity: Results with sigma subunit of Escherichia coli RNA polymerase, wheat germ DNA topoisomerase, and other enzymes

1980 • 1,256 citations

Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene

1982 • 928 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.

1982 • 775 citations

The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes

1981 • 736 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

Differential expression of cellular oncogenes during pre- and postnatal development of the mouse

1982 • 540 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.

1983 • 492 citations

Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene

1983 • 429 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 406 citations

A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product

1983 • 396 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein

1984 • 379 citations

Three human transforming genes are related to the viral ras oncogenes.

1983 • 379 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus

1980 • 356 citations

ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae

1983 • 345 citations

Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses

1979 • 315 citations

Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses.

1982 • 309 citations

Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

1981 • 302 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues

1982 • 241 citations

Kirromycin, an Inhibitor of Protein Biosynthesis that Acts on Elongation Factor Tu

1974 • 186 citations

Comparative biochemical properties of p21 ras molecules coded for by viral and cellular ras genes

1982 • 179 citations

Rhodopsin-enhanced GTPase activity of the inhibitory GTP-binding protein of adenylate cyclase.

1984 • 166 citations

Activation of ras genes in human tumors does not affect localization, modification, or nucleotide binding properties of p21

1984 • 144 citations

Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.

1984 • 132 citations

Spontaneous activation of a human proto-oncogene.

1983 • 114 citations

Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.

1984 • 109 citations

Comparison of the genomic organization of Kirsten and Harvey sarcoma viruses

1978 • 106 citations

Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.

1984 • 100 citations

Frequent Activation of c- kis as a Transforming Gene in Fibrosarcomas Induced by Methylcholanthrene

1983 • 97 citations

Guanosine nucleotide binding by highly purified Ha-ras-encoded p21 protein produced in Escherichia coli.

1984 • 71 citations

Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene.

1983 • 65 citations

Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli

1984 • 57 citations

High-Level Expression in Escherichia coli of Enzymatically Active Harvey Murine Sarcoma Virus p21 ^ras Protein

1983 • 50 citations

[Determination of orthophosphate in the presence of phosphate compounds with an affinity for acids and molybdate].

1958 • 41 citations

Altered regulation of the guanosine 5'-triphosphatase activity in a kirromycin-resistant elongation factor Tu

1981 • 19 citations

Presence of a Kirsten Murine Sarcoma Virus ras Oncogene in Cells Transformed by 3-Methylcholanthrene

1983 • 19 citations

GUANINE NUCLEOTIDE BINDING ACTIVITY OF THE SRC GENE PRODUCT OF RAT‐DERIVED MURINE SARCOMA VIRUSES

1980 • 9 citations

GTPase activity associates with the inhibitory GTP‐binding regulatory component of adenylate cyclase purified from rat brain

1984 • 9 citations