Osteopontin is a ligand for the α4β1 integrin

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

How to measure and predict the molar absorption coefficient of a protein

1995 • 3,771 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.

1993 • 642 citations

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization.

1989 • 627 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

1993 • 537 citations

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro.

1995 • 508 citations

Osteopontin promotes vascular cell adhesion and spreading and is chemotactic for smooth muscle cells in vitro.

1994 • 392 citations

Recognition of osteopontin and related peptides by an alpha v beta 3 integrin stimulates immediate cell signals in osteoclasts.

1991 • 387 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

Renal expression of genes that promote interstitial inflammation and fibrosis in rats with protein-overload proteinuria

1995 • 364 citations

The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine

1991 • 362 citations

Identification of two distinct regions of the type III connecting segment of human plasma fibronectin that promote cell type-specific adhesion.

1987 • 350 citations

Expression and function of the MAdCAM-1 receptor, integrin alpha 4 beta 7, on human leukocytes.

1994 • 350 citations

Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques.

1994 • 314 citations

Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily.

1989 • 285 citations

Macrophages express osteopontin during repair of myocardial necrosis.

1994 • 281 citations

Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta.

1993 • 267 citations

Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1.

1993 • 266 citations

Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques. A possible association with calcification.

1993 • 259 citations

Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by α9β1 Integrin

1996 • 246 citations

A Biochemical Characterization of the Binding of Osteopontin to Integrins αvβ1 and αvβ5

1995 • 245 citations

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues

1991 • 244 citations

Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.

1990 • 228 citations

Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis

1994 • 228 citations

Expression of the integrin $alpha;4$beta;1 on melanoma cells can inhibit the invasive stage of metastasis formation

1994 • 221 citations

VLA‐3: A novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization

1986 • 214 citations

The Mac-1 and p150,95 β2 integrins bind denatured proteins to mediate leukocyte cell-substrate adhesion

1992 • 214 citations

A monoclonal antibody to beta 1 integrin (CD29) stimulates VLA-dependent adherence of leukocytes to human umbilical vein endothelial cells and matrix components.

1992 • 205 citations

Molecular cloning and characterization of 2B7, a rat mRNA which distinguishes smooth muscle cell phenotypes and is identical to osteopontin (secreted phosphoprotein I, 2aR)

1991 • 191 citations

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin.

1991 • 189 citations

Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 Å resolution

1995 • 187 citations

Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4.

1994 • 165 citations

Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin).

1994 • 163 citations

Osteopontin and β ₃ Integrin Are Coordinately Expressed in Regenerating Endothelium In Vivo and Stimulate Arg-Gly-Asp–Dependent Endothelial Migration In Vitro

1995 • 162 citations

Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, mucosal addressin-1, fibronectin, and lymphocyte aggregation.

1994 • 154 citations

Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin

1996 • 151 citations

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1)

1994 • 142 citations

Activation-dependent recognition by hematopoietic cells of the LDV sequence in the V region of fibronectin.

1992 • 140 citations

Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1.

1991 • 134 citations

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors.

1993 • 127 citations

Ca2+Suppresses Cell Adhesion to Osteopontin by Attenuating Binding Affinity for Integrin αvβ3

1995 • 114 citations

Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin

1994 • 109 citations

Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts.

1995 • 101 citations

Activation of the alpha 4 beta 1 integrin through the beta 1 subunit induces recognition of the RGDS sequence in fibronectin.

1994 • 96 citations

Isolation and Biological Properties of Osteopontin from Bovine Milk

1997 • 83 citations

Evidence that a non-RGD domain in rat osteopontin is involved in cell attachment

1993 • 83 citations

The Integrin Very Late Antigen-4 Is Expressed in Human Smooth Muscle Cell

1997 • 68 citations

Regulation of integrin-mediated myeloid cell adhesion to fibronectin: influence of disulfide reducing agents, divalent cations and phorbol ester.

1993 • 54 citations

Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins

1996 • 50 citations

Expression of wild-type and mutated rabbit osteopontin in Escherichia coli, and their effects on adhesion and migration of P388D1 cells

1995 • 49 citations

Immunohistochemical and Molecular Characterization of the Differential Response of the Rat Mesenteric Microvasculature to Angiotensin-II Infusion

1996 • 28 citations

Molecular analysis of the physiological and pathophysiological role of ?4-integrins

1995 • 25 citations

The α4β1 integrin can mediate leukocyte adhesion to casein and denatured protein substrates

1997 • 21 citations