Blockade of Late-phase Airway Responses and Airway Hyperresponsiveness in Allergic Sheep with a Small-molecule Peptide Inhibitor of VLA-4

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

The pathophysiologic role of alpha 4 integrins in vivo.

1994 • 380 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.

1991 • 268 citations

Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.

1991 • 233 citations

Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes

1991 • 231 citations

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep.

1994 • 213 citations

Airway Hyperresponsiveness, Increased Intracellular Spaces of Bronchial Epithelium, and Increased Infiltration of Eosinophils and Lymphocytes in Bronchial Mucosa in Asthma

1992 • 211 citations

Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.

1995 • 208 citations

Cellular and biochemical characteristics of bronchoalveolar lavage fluid in symptomatic nonallergic asthma

1991 • 200 citations

Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.

1992 • 143 citations

Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature.

1994 • 138 citations

Signaling by vascular cell adhesion molecule‐1 (VCAM‐1) through VLA‐4 promotes CD3‐dependent T cell proliferation

1991 • 131 citations

In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration.

1995 • 123 citations

Fibronectin receptor integrins are involved in mast cell activation

1994 • 78 citations

Cellular Markers of Inflammation in the Airways of Allergic Sheep with and without Allergen-induced Late Responses

1988 • 61 citations

Pathophysiologic Role of α4 Integrins in the Lung

1996 • 40 citations

Extracellular metabolites of Pseudomonas aeruginosa produce bronchoconstriction by different mechanisms.

1994 • 32 citations

Therapeutic approaches to asthma based on VLA-4 integrin and its counter receptors

1995 • 29 citations

Aspects on the Reflex Control of Capillary Filtration Transfer Between Blood and Interstitial Fluid

1963 • 15 citations

Morphometric estimation of superoxide generation in allergen-induced airway hyperresponsiveness.

1995 • 11 citations

Effect of TYB-2285 on Antigen-induced Airway Responses in Sheep

1996 • 7 citations

Microwave Giemsa Technique for Paraffin Embedded Tissue Sections

1995 • 2 citations

Deleted Work

1955 • 0 citations