Organismic variables and pain inhibition: Roles of gender and aging

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG¹

1959 • 1,889 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Organization of Endogenous Opiate and Nonopiate Pain Control Systems

1982 • 793 citations

Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone

1977 • 740 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

1977 • 656 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

Intrinsic Mechanisms of Pain Inhibition: Activation by Stress

1984 • 528 citations

Stress-induced analgesia: Neural and hormonal determinants

1980 • 347 citations

The role of endorphins in stress: Evidence and speculations

1980 • 345 citations

Dose-dependent reductions by naloxone of analgesia induced by cold-water stress

1978 • 312 citations

Hormonal determinants of sex differences in avoidance behavior and reactivity to electric shock in the rat.

1970 • 281 citations

Long-Term Stress-Induced Analgesia and Activation of the Opiate System

1981 • 266 citations

A new technique for the investigation of some analgesic drugs on a reflexive behavior in the rat

1961 • 262 citations

Neurotensin: Antinocisponsive action in rodents

1979 • 230 citations

Opiate antagonist, naloxone, strongly reduces analgesia induced by stimulation of a raphe nucleus (centralis inferior)

1977 • 214 citations

Evidence for opioid and non-opioid forms of stimulation-produced analgesia in the rat

1982 • 210 citations

Substance P and analgesia

1976 • 202 citations

Motor and Reflexive Behavior in the Aging Rat

1980 • 197 citations

Alterations in nociception and body temperature after intracisternal administration of neurotensin, beta-endorphin, other endogenous peptides, and morphine.

1979 • 183 citations

Opiate antagonists and long-term analgesic reaction induced by inescapable shock in rats.

1980 • 182 citations

Neurotensin administered intracisternally inhibits responsiveness of mice to noxious stimuli

1977 • 180 citations

Stress-produced analgesia and morphine-produced analgesia: Lack of cross-tolerance

1978 • 170 citations

Multiple Endogenous Opiate and Non‐Opiate Analgesia Systems: Evidence of Their Existence and Clinical Implications^a

1986 • 165 citations

Opioid and non-opioid stress analgesia from cold water swim: importance of stress severity

1986 • 140 citations

Age, sex, and strain differences in the aversive threshold to grid shock in the rat.

1969 • 135 citations

Effect of age on glucose-stimulated insulin release by the beta-cell of the rat.

1979 • 135 citations

Pharmacological characterization of the epsilon-opiate receptor.

1981 • 133 citations

N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat

1983 • 126 citations

Age-Related Changes in Central Nervous System Beta-Endorphin and ACTH

1980 • 120 citations

Ageing, opioid analgesia and the pineal gland

1983 • 120 citations

Analgesic activity of substance P following intracerebral administration in rats

1978 • 119 citations

Stressor Controllability and Stress‐Induced Analgesia

1986 • 110 citations

Effect of age on sensitivity to pain and brain opiate receptors

1981 • 109 citations

Stress-induced analgesia: Time course of pain reflex alterations following cold water swims

1978 • 109 citations

Opiate and non-opiate mechanisms of stress-induced analgesia: Cross-tolerance between stressors

1979 • 107 citations

Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone.

1981 • 106 citations

An inability to antagonize with naloxone the elevated nociceptive thresholds resulting from electrical stimulation of the mesencephalic central gray

1976 • 106 citations

Comparison between naloxone reversal of morphine and electrical stimulation induced analgesia in the rat mesencephalon

1976 • 105 citations

Sex and day-night differences in opiate-induced responses of insular wild deer mice, Peromyscus maniculatus triangularis

1987 • 104 citations

Antinociceptive effects of intraventricular or systemic administration of vasopressin in the rat

1980 • 101 citations

Androgen structure and male sexual behavior in the castrated rat

1973 • 101 citations

Age-dependent changes in the β-endorphin content of discrete rat brain nuclei

1981 • 100 citations

Neuropharmacological and Neuroendocrine Substrates of Stress‐Induced Analgesia^a

1986 • 100 citations

The direction of opioid agonists towards μ-, δ- and ε-receptors in the vas deferens of the mouse and the rat

1980 • 99 citations

Characterization of vasopressin analgesia.

1982 • 96 citations

Physical dependence on physiologically released endogenous opiates

1982 • 95 citations

Age-related changes in central nervous system enkephalins and substance P

1981 • 95 citations

Gender differences in two forms of cold-water swim analgesia.

1986 • 91 citations

3H-dihydromorphine binding in brain regions of young and aged rats

1980 • 91 citations

Ontogeny of sex differences in open-field behavior and sensitivity to electric shock in the rat

1976 • 84 citations

Differential effects of ovarian hormones on reactivity to electric footshock in the rat

1978 • 82 citations

Intermittent cold water stress-analgesia in rats: Cross-tolerance to morphine

1984 • 80 citations

Gender differences in two forms of cold-water swim analgesia

1986 • 78 citations

Ovarian steroids and modulation of morphine-induced analgesia and catalepsy in female rats

1983 • 76 citations

Vasopressin analgesia: Specificity of action and non-opioid effects

1984 • 75 citations

Stress-induced opioid analgesia and activity in deer mice: sex and population differences

1987 • 74 citations

Comparisons between warm and cold water swim stress in mice

1984 • 73 citations

Naloxazone and pain-inhibitory systems: evidence for a collateral inhibition model

1982 • 72 citations

Alterations in Dihydromorphine Binding in Cerebral Hemispheres of Aged Male Rats

1981 • 72 citations

Biphasic alterations of nociceptive thresholds induced by food deprivation

1978 • 71 citations

Changes of β‐Endorphin and Met‐Enkephalin Content in the Hypothalamus‐Pituitary Axis Induced by Aging

1983 • 69 citations

Analgesia Following Defeat in an Aggressive Encounter: Development of Tolerance and Changes in Opioid Receptors^a

1986 • 68 citations

Cold water stress analgesia in rats: Differential effects of naltrexone

1984 • 68 citations

Modulation of gender-specific effects upon swim analgesia in gonadectomized rats

1987 • 68 citations

Effect of Age and Weight on Plasma Glucose and Insulin Responses in the Rat†

1977 • 67 citations

Dissociation of cold-water swin and morphine analgesia in Brattleboro rats with diabetes insipidus

1980 • 66 citations

Vaginal Stimulation‐Produced Analgesia in Rats and Women^a

1986 • 65 citations

The correlation between swim-stress induced antinociception and [3H] leu-enkephalin binding to brain homogenates in mice

1981 • 63 citations

Immunoreactive β-endorphin in the plasma, pituitary and hypothalamus of young and old male rats

1981 • 61 citations

Changes in stimulus reactivity following gonadectomy in male and female rats of different ages

1972 • 61 citations

2-Deoxy-D-glucose analgesia: Influences of opiate and non-opiate factors

1979 • 61 citations

Gonadectomy and sensitivity to electric shock in the rat☆

1977 • 57 citations

Effects of diverse androgens on estrous behavior, lordosis reflex, and genital tract morphology in the rat*1

1971 • 57 citations

Naloxone and cold-water swim analgesia: Parametric considerations and individual differences

1983 • 54 citations

Possible physiological role of adrenal and gonadal steroids in morphine analgesia

1982 • 51 citations

Central antinociceptive effects of lysine-vasopressin and an analogue

1982 • 51 citations

Immunoreactive-β-endorphin and LHRH levels in the brains of aged male rats with impaired sex behavior

1984 • 50 citations

Effects of aging on pain responses and analgesic efficacy of morphine and clonidine in rats

1982 • 49 citations

Impairments in Analgesic, Hypothermic, and Glucoprivic Stress Responses following Neonatal Monosodium Glutamate

1984 • 48 citations

Tolerance and cross tolerance with morphine resulting from physiological release of endogenous opiates

1982 • 48 citations

Environmentally Induced Analgesia: An Age-Related Decline in an Endogenous Opioid System

1985 • 45 citations

Antagonism of stress-induced analgesia by D-phenylalanine, an anti-enkephalinase

1980 • 44 citations

Effect of diverse estrogens on estrous behavior and genital tract development in ovariectomized rats

1971 • 43 citations

Gender determinants of opioid mediation of swim analgesia in rats

1988 • 41 citations

Stress-Induced Analgesia

1985 • 39 citations

A reduction in the concentration of immunoreactive corticotropin, malanotropin and lipotropin in the brain of the aging rat

1982 • 38 citations

Interaction of Age and Thyroid Hormone Status on Beta-Endorphin Content in Rat Corpus Striatum and Hypothalamus

1981 • 36 citations

Nociceptive thresholds following food restriction and return to free-feeding

1984 • 35 citations

Naltrexone antagonizes the biobehavioral adaptation to cold water stress in rats

1985 • 34 citations

The role of hormones in changing adaptive mechanisms during aging.

1980 • 32 citations

Age-related decrements in morphine analgesia: A parametric analysis

1986 • 29 citations

Effect of age on acute morphine response in the rat.

1978 • 28 citations

The analgesia produced by food deprivation in 4-month old, 14-month old, and 24-month old rats

1986 • 27 citations

Age-related differences in electric shock detection and escape thresholds in sprague-dawley albino rats

1978 • 26 citations

Age-related decrements in the analgesic response to cold-water swims

1986 • 25 citations

Changes of sensitivity to pain in relation to postnatal development in rats

1971 • 24 citations

Environmentally induced analgesia: Age-related decline in a neurally mediated, nonopioid system.

1986 • 24 citations

Effect of age and long-term stress experience on adaptation to stress analgesia in mature rats: Role of opioids.

1985 • 24 citations

Environmentally-Induced Analgesia: Age-Related Differences in a Hormonally-Mediated, Nonopioid System

1986 • 23 citations

Multiple Neurochemical and Hormonal Mechanisms of Stress‐Induced Analgesia^a

1986 • 22 citations

Effect of age and long-term stress experience on adaptation to stress analgesia in mature rats: Role of opioids.

1985 • 22 citations

Chronic stress, aging and morphine analgesia: chronic stress affects the reactivity to morphine in young mature but not old rats.

1985 • 20 citations

Chronic opioid antagonist treatment facilatates nonopioid, stress-induced analgesia

1987 • 20 citations

Environmentally induced analgesia: Age-related decline in a neurally mediated, nonopioid system.

1986 • 19 citations

Age-related decrements in the analgesic and hyperphagic responses to 2-deoxy-D-glucose

1985 • 14 citations

Sex differences in magnetic field inhibition of morphine-induced responses of wild deer mice, Peromyscus maniculatus triangularis

1987 • 12 citations

Differential alterations in opioid analgesia following neonatal monosodium glutamate treatment

1985 • 12 citations

Maintenance of beta-endorphin analgesia across age cohorts

1987 • 11 citations

Selective potentiations in opioid analgesia following scopolamine pretreatment

1986 • 9 citations