Insulin and phorbol ester stimulate phosphorylation of a 40-kDa protein in adipocyte plasma membranes.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Selected methods in cellular immunology

1981 • 1,915 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system

1982 • 680 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1

1980 • 477 citations

PREPARATION AND CHARACTERIZATION OF A PLASMA MEMBRANE FRACTION FROM ISOLATED FAT CELLS

1970 • 402 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

1983 • 291 citations

Metabolism of Isolated Fat Cells

1966 • 277 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

A partial view of the mechanism of insulin action

1981 • 215 citations

Identification of a calcium- and phospholipid-dependent phorbol ester binding activity in the soluble fraction of mouse tissues

1983 • 168 citations

Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.

1983 • 160 citations

Direct addition of insulin inhibits a high affinity Ca2+-ATPase in isolated adipocyte plasma membranes

1979 • 151 citations

Phosphorylation of glycogen synthase by the Ca2+- and phospholipid-activated protein kinase (protein kinase C).

1984 • 127 citations

Phospholipid-sensitive Ca2+-dependent protein kinase: a major protein phosphorylation system

1984 • 120 citations

Effect of insulin, catecholamines and calcium ions on phospholipid metabolism in isolated white fat-cells

1980 • 111 citations

Biochemical Actions of Hormones

1983 • 111 citations

Insulin acutely increases phospholipids in the phosphatidate-inositide cycle in rat adipose tissue.

1982 • 110 citations

[4] Subcellular Fractionation of Adipocytes

1974 • 103 citations

Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents

1983 • 76 citations

Ability of insulin to increase calcium binding by adipocyte plasma membranes.

1976 • 76 citations

Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells.

1984 • 75 citations

Phospholipids as intermediates in hormone action

1984 • 73 citations

Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase

1984 • 66 citations

Modification of glycogen synthase activity in isolated rat hepatocytes by tumor-promoting phorbol esters: evidence for differential regulation of glycogen synthase and phosphorylase.

1983 • 62 citations

The action of insulin on the incorporation of [32P]phosphate in the phospholipids of rat adipose tissue

1966 • 61 citations

Insulin-like Effect of Clostridial Phospholipase C, Neuraminidase, and Other Bacterial Factors on Brown Fat Cells

1971 • 54 citations

Hormone-receptor coupling and the molecular mechanism of insulin action in the adipocyte: A paradigm for Ca2+ homeostasis in the initiation of the insulin-induced metabolic cascade

1984 • 51 citations

Evidence that the insulin receptor‐associated protein kinase acts as a phosphatidylinositol kinase

1984 • 44 citations

The effect of insulin on 32P1 incorporation into rat fat cell phospholipids

1974 • 42 citations

Calcium-dependence of insulin receptor phosphorylation

1983 • 40 citations

Structure of the Insulin Receptor of Rat Adipocytes: The Three Interconvertible Redox Forms

1983 • 37 citations

Direct effect of insulin on the binding of calmodulin to rat adipocyte plasma membranes.

1983 • 32 citations

Calcium as Modulator of the Hormonal‐Receptors– Biological‐Response Coupling System

1978 • 25 citations

The Mechanism of Action of Insulin on Phospholipid Metabolism in Rat Adipose Tissue: Requirement for Protein Synthesis and a Carbohydrate Source, and Relationship to Activation of Pyruvate Dehydrogenase

1984 • 25 citations

Insulin treatment acutely increases the concentration of phosphatidylserine in rat adipose tissue

1983 • 24 citations

In vivo control of the insulin‐suppressible high‐affinity Ca²⁺‐ATPase of fat cell membranes by growth hormone and its possible involvement in the regulation of glucose transport

1981 • 23 citations

Effect of calcium on [125I]insulin binding to rat adipocytes

1978 • 20 citations

Identification of an insulin-sensitive calcium-stimulated phosphoprotein in rat adipocyte plasma membranes.

1982 • 18 citations

Comparison of phospholipid effects on insulin-sensitive low Km cyclic AMP phosphodiesterase in adipocyte plasma membranes and microsomes

1983 • 18 citations

Inositol trisphosphate activates pyruvate dehydrogenase in isolated fat cells

1984 • 14 citations

The effect of collagenase preparations contaminated with phospholipase C activity on adipose tissue lecithin

1970 • 10 citations

Inhibition of Noradrenaline‐Stimulated Lipolysis and Cyclic AMP Accumulation in Isolated Rat Adipocytes by Purified Phospholipase C and Theta‐Toxin from Clostridium Perfringens

1978 • 10 citations

Regulation of target cell responsiveness

1985 • 6 citations