Insulin receptor signaling through non‐tyrosine kinase pathways: Evidence from anti‐receptor antibodies and insulin receptor mutants

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

1989 • 978 citations

Structural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes

1988 • 963 citations

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

1991 • 774 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

The insulin receptor and the molecular mechanism of insulin action.

1988 • 426 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

1991 • 344 citations

The Insulin Receptor: Molecular Biology and Transmembrane Signaling*

1987 • 285 citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

1987 • 232 citations

Ras p21 as a Potential Mediator of Insulin Action in Xenopus Oocytes

1987 • 224 citations

Phosphatidylinositol-Glycan Anchors of Membrane Proteins: Potential Precursors of Insulin Mediators

1988 • 199 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Purification of a phosphatidylinositol-glycan-specific phospholipase C from liver plasma membranes: a possible target of insulin action.

1987 • 142 citations

The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor.

1984 • 118 citations

The regulatory role of known tyrosine autophosphorylation sites of the insulin receptor kinase domain. An assessment by replacement with neutral and negatively charged amino acids.

1991 • 112 citations

Insulin Receptor Phosphorylation May Not Be a Prerequisite for Acute Insulin Action

1984 • 109 citations

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth.

1990 • 107 citations

A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.

1990 • 94 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.

1988 • 92 citations

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver

1986 • 84 citations

Protein phosphorylation and protein kinase activities in BC3H-1 myocytes. Differences between the effects of insulin and phorbol esters.

1986 • 78 citations

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase

1989 • 76 citations

Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes

1988 • 69 citations

Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.

1990 • 67 citations

Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist

1983 • 64 citations

Substrates for Insulin-Receptor Kinase

1990 • 63 citations

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

1989 • 63 citations

The pathway mediating insulin's effects on pyruvate dehydrogenase bypasses the insulin receptor tyrosine kinase

1991 • 58 citations

Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor.

1987 • 56 citations

Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163

1989 • 49 citations

Some Thoughts on the Mechanism of Action of Insulin

1991 • 49 citations

Evidence that insulin plus ATP may induce a conformational change in the beta subunit of the insulin receptor without inducing receptor autophosphorylation.

1991 • 48 citations

Insulin-mimetic anti-insulin receptor monoclonal antibodies stimulate receptor kinase activity in intact cells.

1990 • 48 citations

Monoclonal Antibodies Mimic Insulin Activation of Ribosomal Protein S6 Kinase without Activation of Insulin Receptor Tyrosine Kinase

1989 • 47 citations

Cascade of autophosphorylation in the β‐subunit of the insulin receptor

1989 • 43 citations

Use of an anti-insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation.

1988 • 39 citations

Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA

1990 • 29 citations

Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163

1991 • 23 citations

Some thoughts on the mechanism of action of insulin

1991 • 17 citations

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected fibroblasts without activating receptor kinase

1989 • 16 citations

Psychosocial Considerations

1981 • 4 citations