Cell cycle regulators and their abnormalities in breast cancer

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

New functional activities for the p21 family of CDK inhibitors.

1997 • 1,414 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).

1995 • 1,117 citations

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

1998 • 1,058 citations

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

1997 • 1,055 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Translational Control of p27 ^Kip1 Accumulation During the Cell Cycle

1996 • 864 citations

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

1997 • 861 citations

CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 • 698 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

1994 • 657 citations

Cyclin D1 protein expression and function in human breast cancer

1994 • 515 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma.

1991 • 454 citations

Estrogen-induced Activation of Cdk4 and Cdk2 during G1-S Phase Progression Is Accompanied by Increased Cyclin D1 Expression and Decreased Cyclin-dependent Kinase Inhibitor Association with Cyclin E-Cdk2

1997 • 438 citations

Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.

1994 • 370 citations

Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma.

1989 • 367 citations

High level expression of p27 ^kip1 and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 ^kip1 and degree of malignancy in human breast and colorectal cancers

1997 • 364 citations

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.

1997 • 354 citations

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.

1996 • 344 citations

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.

1995 • 338 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.

1997 • 326 citations

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.

1993 • 295 citations

DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.

1994 • 279 citations

Cyclin D1 expression is regulated by the retinoblastoma protein.

1994 • 235 citations

Inactivation of p16 in Human Mammary Epithelial Cells by CpG Island Methylation

1998 • 231 citations

Deregulation of cyclin E in breast cancer.

1995 • 227 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

Determination of the prognostic value of cyclin D1 overexpression in breast cancer.

1995 • 215 citations

Cyclin D1 expression in invasive breast cancer. Correlations and prognostic value.

1997 • 207 citations

Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status

1996 • 198 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

1997 • 190 citations

A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer

1996 • 181 citations

Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation.

1995 • 179 citations

Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer

1995 • 177 citations

p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

1995 • 155 citations

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

1997 • 150 citations

High frequency of aberrant p16(INK4A) expression in human breast cancer.

1996 • 134 citations

Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control.

1995 • 129 citations

Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene.

1995 • 127 citations

Immunohistochemistry of Cyclin D1 in Human Breast Cancer

1994 • 125 citations

Cyclin E, a redundant cyclin in breast cancer

1996 • 121 citations

p21WAF1 immunohistochemical expression in breast carcinoma: correlations with clinicopathological data, oestrogen receptor status, MIB1 expression, p53 gene and protein alterations and relapse-free survival

1996 • 121 citations

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

1997 • 119 citations

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

1992 • 113 citations

Retinoblastoma and p16 proteins in mammary carcinoma: Their relationship to cyclin D1 and histopathological parameters

1998 • 112 citations

Cyclin D1 as a cellular proto-oncogene

1995 • 111 citations

p21/WAF1/CIP1 EXPRESSION IN NORMAL MUCOSA AND IN ADENOMAS AND ADENOCARCINOMAS OF THE COLON: ITS RELATIONSHIP WITH DIFFERENTIATION

1996 • 110 citations

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.

1994 • 107 citations

How viral oncogenes make the cell cycle

1996 • 89 citations

Mutational analysis of the human cyclin-dependent kinase inhibitor p27kip1 in primary breast carcinomas

1996 • 86 citations

Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast.

1997 • 84 citations

Chromosome 11q13 abnormalities in human breast cancer.

1993 • 82 citations

CYCLIN D1 AND RETINOBLASTOMA GENE EXPRESSION IN HUMAN BREAST CARCINOMA: CORRELATION WITH TUMOUR PROLIFERATION AND OESTROGEN RECEPTOR STATUS

1997 • 78 citations

Cyclin D1 and associated proteins in mammary ductal carcinomain situ and atypical ductal hyperplasia

1998 • 76 citations

Growth Factor, Steroid, and Steroid Antagonist Regulation of Cyclin Gene Expression Associated With Changes in T-47D Human Breast Cancer Cell Cycle Progression

1993 • 74 citations

Expression of the cyclin‐dependent kinase inhibitors p16^INK4, p15^INK4B and p21Waf1/cip1 in human breast cancer

1995 • 71 citations

Overexpression of cyclin E in the HC11 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27(Kip1).

1996 • 60 citations

Clinical significance of cyclin D1 expression in patients with node-positive breast carcinoma treated with adjuvant therapy

1996 • 60 citations

Retinoblastoma and p53 gene product expression in breast carcinoma: Immunohistochemical analysis and clinicopathologic correlation

1992 • 59 citations

p21WAF1/Cip1 is associated with cyclin D1CCND1 expression and tubular differentiation but is independent of p53 overexpression in human breast carcinoma

1998 • 55 citations

p21WAF1/Cip1 expression is associated with cell differentiation but not with p53 mutations in squamous cell carcinomas of the larynx

1997 • 51 citations

Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue

1998 • 47 citations

The cell cycle in breast cancer

1997 • 47 citations

Cyclin gene expression and growth control in normal and neoplastic human breast epithelium

1993 • 44 citations

Constitutive overexpression of cyclin D1 does not prevent inhibition of hormone-responsive human breast cancer cell growth by antiestrogens.

1998 • 34 citations

Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression

1996 • 22 citations

Analysis of phosphorylation of pRB and its regulatory proteins in breast cancer.

1997 • 20 citations

Absence of p16 gene (CDKN2) deletions in microdissected primary breast carcinoma specimens

1997 • 6 citations