The cell cycle in breast cancer

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

1995 • 1,353 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G₁/S-Regulatory Genes

1995 • 910 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer

1993 • 777 citations

Mitosis in transition

1994 • 745 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

1995 • 713 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

1995 • 653 citations

Regulation of the cyclin E gene by transcription factor E2F1.

1995 • 634 citations

P53 expression in breast cancer

1988 • 612 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

Mutations and altered expression of p16INK4 in human cancer.

1994 • 547 citations

Redundant cyclin overexpression and gene amplification in breast cancer cells.

1993 • 526 citations

Joining the complex: Cyclin-dependent kinase inhibitory proteins and the cell cycle

1994 • 460 citations

Telomerase Activity in Human Breast Tumors

1996 • 440 citations

The p53 Gene in Breast Cancer: Prognostic Value of Complementary DNA Sequencing Versus Immunohistochemistry

1996 • 387 citations

Regulation of cyclin E transcription by E2Fs and retinoblastoma protein.

1996 • 387 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E.

1996 • 365 citations

Reproducibility of mitosis counting in 2,469 breast cancer specimens: Results from the Multicenter Morphometric Mammary Carcinoma Project

1992 • 359 citations

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

1995 • 355 citations

Association of Overexpression of Tumor Suppressor Protien p53 With Rapid Cell Proliferation and Poor Prognosis in Node-Negative Breast Cancer Patients

1992 • 349 citations

Indicators of Prognosis in Node-Negative Breast Cancer

1990 • 348 citations

Cyclin E, a Potential Prognostic Marker in Breast Cancer.

1997 • 346 citations

Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions

1995 • 334 citations

Cdk inhibitors: on the threshold of checkpoints and development

1994 • 326 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Cyclin Ubiquitination: The destructive end of mitosis

1995 • 304 citations

Cyclin dependent kinase regulation

1995 • 286 citations

Association of DNA index and S-phase fraction with prognosis of nodes positive early breast cancer.

1987 • 263 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.

1994 • 253 citations

Cyclin D and oncogenesis

1993 • 233 citations

CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.

1994 • 221 citations

Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: link between cell cycle control and malignant transformation.

1994 • 219 citations

Mammalian G1 cyclins

1994 • 219 citations

Determination of the prognostic value of cyclin D1 overexpression in breast cancer.

1995 • 215 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Cyclin E overexpression, a negative prognostic factor in breast cancer with strong correlation to oestrogen receptor status

1996 • 198 citations

Retinoblastoma protein family in cell cycle and cancer: A review

1996 • 198 citations

Amplification of cyclin genes in colorectal carcinomas.

1993 • 197 citations

Amplification of genes within the chromosome 11q13 region is indicative of poor prognosis in patients with operable breast cancer.

1992 • 194 citations

Proliferation index as a prognostic marker in breast cancer

1993 • 181 citations

A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer

1996 • 181 citations

TP53 mutations and breast cancer prognosis: Particularly poor survival rates for cases with mutations in the zinc‐binding domains

1995 • 179 citations

Cyclins, CDKs and cancer

1995 • 176 citations

Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer.

1995 • 166 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Deregulation of cyclin E and D1 in breast cancer is associated with inactivation of the retinoblastoma protein

1997 • 150 citations

Frequent Amplification of the Cyclin E Gene in Human Gastric Carcinomas

1995 • 148 citations

High frequency of aberrant p16(INK4A) expression in human breast cancer.

1996 • 134 citations

Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control.

1995 • 129 citations

p53 and c-erbB-2 Protein Expression in Breast Carcinomas: An Immunohistochemical Study Including Correlations with Receptor Status, Proliferation Markers, and Clinical Stage in Human Breast Cancer

1992 • 126 citations

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

1991 • 124 citations

c-myc, c-erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma.

1992 • 123 citations

Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens, including fine needle aspirates

1996 • 120 citations

Cyclin E and cyclin A as candidates for the restriction point protein.

1993 • 119 citations

Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas

1995 • 114 citations

The retinoblastoma gene in breast cancer: allele loss is not correlated with loss of gene protein expression.

1992 • 113 citations

Biologic and clinicopathologic factors as indicators of specific relapse types in node-negative breast cancer.

1995 • 111 citations

Mutational analysis of CDKN2 (MTS1/p16ink4) in human breast carcinomas.

1994 • 107 citations

p53 immunohistochemical analysis in breast cancer with four monoclonal antibodies: comparison of staining and PCR-SSCP results

1994 • 103 citations

p53 protein expression in breast cancer as related to histopathological characteristics and prognosis

1993 • 101 citations

Relationship betweenp53 gene abnormalities and other tumour characteristics in breast-cancer prognosis

1996 • 97 citations

Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells.

1995 • 95 citations

How viral oncogenes make the cell cycle

1996 • 89 citations

Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level.

1991 • 88 citations

Flow cytometric analysis of DNA stemline heterogeneity in primary and metastatic breast cancer

1991 • 87 citations

Cell kinetics in human breast cancer: Comparison between the prognostic value of the cytofluorimetric S‐phase fraction and that of the antibodies to Ki‐67 and PCNA antigens detected by immunocytochemistry

1994 • 87 citations

Telomerase activity is associated with cell cycle deregulation in human breast cancer.

1997 • 81 citations

UVB radiation induces p21Cip1/WAF1 and mediates G1 and S phase checkpoints.

1996 • 77 citations

Proliferating cell nuclear antigen immunohistochemistry using monoclonal antibody 19A2 and a new antigen retrieval technique has prognostic impact in archival paraffin-embedded node-negative breast cancer.

1993 • 77 citations

Expression of the cyclin‐dependent kinase inhibitors p16^INK4, p15^INK4B and p21Waf1/cip1 in human breast cancer

1995 • 71 citations

S-phase fraction is a prognostic factor in stage I breast carcinoma.

1993 • 70 citations

Cell proliferation of breast cancer evaluated by anti-BrdU and anti-Ki-67 antibodies: Its prognostic value on short-term recurrences

1993 • 69 citations

Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival

1995 • 68 citations

Heterogeneity in renal cell carcinoma and its impact on prognosis - a flow cytometric study

1996 • 68 citations

Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: An immunohistochemical study

1992 • 67 citations

Prognostic significance of proliferation associated nucleolar antigen P120 in human breast carcinoma.

1991 • 66 citations

Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas.

1996 • 65 citations

Retinoblastoma and p53 gene product expression in breast carcinoma: Immunohistochemical analysis and clinicopathologic correlation

1992 • 59 citations

Thymidine labeling index and Ki-67 growth fraction in breast cancer: Comparison and correlation with prognosis

1994 • 59 citations

A comparative study of histopathology, hormone receptors, peanut lectin binding, ki-67 immunostaining, and nucleolar organizer region-associated proteins in human breast cancer

1991 • 58 citations

An immunohistochemical study of p53 with correlations to histopathological parameters, c-erbB-2, proliferating cell nuclear antigen, and prognosis

1995 • 53 citations

The retinoblastoma protein as a fundamental mediator of growth and differentiation signals.

1995 • 51 citations

Factors affecting relapse in node-negative breast cancer. A multivariate analysis including the labeling index

1989 • 51 citations

Breast cancer proliferation measured on cytological samples: a study by flow cytometry of S-phase fractions and BrdU incorporation

1991 • 50 citations

A comparison between bromodeoxyuridine and 3H thymidine labeling in human breast tumors.

1991 • 49 citations

The association of p53 immunopositivity with tumor proliferation and other prognostic indicators in breast cancer.

1994 • 46 citations

High levels of DNA index heterogeneity in advanced breast carcinomas. Evidence for DNA ploidy differences between lymphatic and hematogenous metastases

1993 • 45 citations

DNA ploidy and the percentage of cells in S-phase as prognostic factors for women with lymph node negative breast cancer

1994 • 44 citations

Cyclin gene expression and growth control in normal and neoplastic human breast epithelium

1993 • 44 citations

p16INK4a: a gene with a dual capacity to encode unrelated proteins that inhibit cell cycle progression.

1996 • 40 citations

Bromodeoxyuridine labeling for S-phase measurement in breast carcinoma

1993 • 40 citations

Frequent allele loss on 9p21–22 defines a smallest common region in the vicinity of theCDKN2 gene in sporadic breast cancer

1996 • 38 citations

Cell kinetics in vivo of human breast cancer

1996 • 35 citations

Analysis of p16 gene deletion and point mutation in breast carcinoma

1995 • 34 citations

p53 in breast cancer. Its relation to histological grade, lymph-node status, hormone receptors, cell-proliferation fraction (ki-67) and c-erbB-2. Immunohistochemical study of 153 cases.

1995 • 34 citations

Infrequent CDKN2 (MTS1/p16) gene alterations in human primary breast cancer

1995 • 33 citations

Mitotic frequency as a prognostic factor in breast cancer

1995 • 32 citations

Flow cytometry in node‐positive breast cancer: Cancer and leukemia group B protocol 8869

1995 • 31 citations

Recurrence-free survival in breast cancer improved by adjuvant tamoxifen -especially for progesterone receptor positive tumors with a high proliferation

1995 • 29 citations

Proliferating-cell nuclear antigen (PC10) immunolabelling and other proliferation indices as prognostic factors in breast cancer

1993 • 29 citations

Partial deletions of the CDKN2 and MTS2 putative tumor suppressor genes in a myxoid chondrosarcoma

1996 • 24 citations

In Vivo Measurement of Breast Cancer Growth Rate

1991 • 23 citations

Prognostic value of quantitatively measured AgNORs in ductal mammary carcinoma.

1994 • 21 citations

Prognostic value of the combined assessment of proliferating cell nuclear antigen immunostaining and nuclear DNA content in invasive human mammary carcinomas

1993 • 20 citations

Prognostic significance of flow cytometric DNA analysis and estrogen receptor content in breast carcinomas — a 10 year survival study

1992 • 20 citations

Mammographic growth rate, DNA ploidy, and S-phase fraction analysis in breast carcinoma. A prognostic evaluation in a screened population

1992 • 20 citations

RB1 oncosuppressor gene over-expression inhibits tumor progression and induces melanogenesis in metastatic melanoma cells.

1996 • 19 citations

Regional differences in breast cancer survival are correlated with differences in differentiation and rate of proliferation

1992 • 17 citations

Proliferation-associated nucleolar antigen P120: a prognostic marker in node-negative breast cancer.

1994 • 17 citations

Comparison of DNA Content, S-Phase Fraction, and Survival Between Medullary and Ductal Carcinoma of the Breast

1995 • 16 citations

Use of the Mitotic Counts for the Prognosis and Grading of Breast Cancer

1994 • 16 citations

Intratumoral heterogeneity of DNA ploidy in breast carcinomas: A flow cytometric assessment of sampling techniques

1995 • 16 citations

Prognostic Studies in Breast Cancer: Multivariate combination of nodal status, proliferation index, tumor size, and DNA ploidy

1994 • 16 citations

Nucleolar Organizer Regions Related to Morphometry, Flow Cytometry, Sex Steroid Receptor Content, Tumour Histology and Prognosis in Female Breast Cancer

1993 • 14 citations

Prognostic value of proliferative activity in lymph node metastases of patients with breast cancer.

1991 • 13 citations

Assessment of Proliferating Cell Nuclear Antigen (PCNA) in Breast Cancer Using Anti-PCNA PC10 and 19A2: Correlation with 5-Bromo-2′-Deoxyuridine or Tritiated Thymidine Labeling and Flow Cytometric Analysis

1994 • 11 citations

Inter-institutional reproducibility of flow cytometric DNA-analysis in breast carcinomas.

1994 • 8 citations

Comparison of classic and quantitative prognostic factors in hormone receptor-positive and hormone receptor-negative female breast cancer

1993 • 8 citations

DNA content in colorectal carcinoma: a flow cytometric study of the epithelial fraction.

1995 • 5 citations