Novel gene families involved in neural pathfinding

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6

1994 • 1,346 citations

Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord

1994 • 1,311 citations

Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

1993 • 1,146 citations

Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes

1994 • 1,005 citations

The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules

1993 • 930 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

1995 • 687 citations

The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons

1995 • 566 citations

Sernaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord

1995 • 492 citations

Fasciclin IV: Sequence, expression, and function during growth cone guidance in the grasshopper embryo

1992 • 369 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

Neuroglia and Pioneer Neurons Express UNC-6 to Provide Global and Local Netrin Cues for Guiding Migrations in C. elegans

1996 • 359 citations

Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension

1995 • 352 citations

Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

1994 • 332 citations

The Transmembrane Tyrosine Phosphatase DLAR Controls Motor Axon Guidance in Drosophila

1996 • 331 citations

Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase

1993 • 288 citations

Receptor Tyrosine Phosphatases Are Required for Motor Axon Guidance in the Drosophila Embryo

1996 • 273 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

Localized collapsing cues can steer growth cones without inducing their full collapse

1995 • 241 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

1992 • 226 citations

A family of molecules related to collapsin in the embryonic chick nervous system

1995 • 225 citations

The Role of the Floor Plate in Axon Guidance

1995 • 218 citations

Semaphorin II can function as a selective inhibitor of specific synaptic arborizations

1995 • 200 citations

Mediation by G Proteins of Signals That Cause Collapse of Growth Cones

1993 • 187 citations

Chemorepulsion of axons in the developing mammalian central nervous system

1993 • 180 citations

Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member

1995 • 179 citations

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

1994 • 174 citations

ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

1995 • 155 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

1994 • 141 citations

Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33.

1992 • 140 citations

The Distribution of Collapsin-1 mRNA in the Developing Chick Nervous System

1996 • 139 citations

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

1994 • 135 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Position, guidance, and mapping in the developing visual system

1993 • 118 citations

The likeness of being: Phylogenetically conserved molecular mechanisms of growth cone guidance

1994 • 109 citations

The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development

1996 • 105 citations

Semaphorins: mediators of repulsive growth cone guidance

1996 • 103 citations

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

1995 • 101 citations

Guidance of cerebellofugal axons in the rat embryo: Directed growth toward the floor plate and subsequent elongation along the longitudinal axis

1995 • 100 citations

Ventral spinal cord inhibition of neurite outgrowth from embryonic rat dorsal root ganglia

1993 • 99 citations

Chemorepulsion of developing motor axons by the floor plate

1995 • 98 citations

A common denominator of growth cone guidance and collapse?

1990 • 93 citations

Development of the visual system of the chick--a review.

1992 • 90 citations

Telling Axons Where to Grow: A Role for Eph Receptor Tyrosine Kinases in Guidance

1995 • 76 citations

Floor plate chemoattracts crossed axons and chemorepels uncrossed axons in the vertebrate brain

1995 • 71 citations

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

1995 • 68 citations

Axonal guidance by an avoidance mechanism.

1990 • 68 citations

cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

1994 • 62 citations

Axonal localisation of the CAM-like tyrosine phosphatase CRYPα: a signalling molecule of embryonic growth cones

1995 • 61 citations

Of nerve growth cones, leukocytes and memory: second messenger systems and growth-regulated proteins

1986 • 57 citations

The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum

1995 • 48 citations

Contact inhibition/collapse and pathfinding of neural crest cells in the zebrafish trunk

1996 • 43 citations

Pertussis toxin specifically inhibits growth cone guidance by a mechanism independent of direct G protein inactivation

1995 • 38 citations

cDNA Cloning and Characterization of a Cek7 Receptor Protein-tyrosine Kinase Ligand That Is Identical to the Ligand (ELF-1) for the Mek-4 and Sek Receptor Protein-tyrosine Kinases

1995 • 37 citations