Astroglia in Alzheimer's disease

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid Deposits and Amyloidosis

1980 • 1,787 citations

Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

1981 • 1,701 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence

1972 • 1,456 citations

Fine structural localization of glutamine synthetase in astrocytes of rat brain

1979 • 1,318 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

An acidic protein isolated from fibrous astrocytes

1971 • 1,192 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Cytotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system

1971 • 808 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Proteoglycans in Cell Regulation

1989 • 691 citations

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

1982 • 677 citations

Observations on the brains of non-demented old people

1968 • 656 citations

ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA.

1964 • 646 citations

Amino acid neurotransmitters and their pathways in the mammalian central nervous system

1983 • 646 citations

The Macrophage as an Effector Cell

1980 • 628 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Senescent forgetfulness: benign and malignant.

1962 • 565 citations

Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sites

1983 • 522 citations

Prevalence and Malignancy of Alzheimer Disease

1976 • 515 citations

Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons.

1982 • 509 citations

Amyloid Deposits and Amyloidosis

1980 • 506 citations

Serotonin nerve terminals in adult rat neocortex

1975 • 504 citations

Distinct Monoamine Oxidase A and B Populations in Primate Brain

1985 • 496 citations

Excitatory amino acids and Alzheimer's disease

1989 • 485 citations

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

1979 • 445 citations

Cell loss in the locus coeruleus in senile dementia of Alzheimer type

1981 • 443 citations

ALZHEIMER’S DISEASE —AN ELECTRON MICROSCOPICAL STUDY

1964 • 440 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Functional receptors for neurotransmitters on astroglial cells

1987 • 436 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease

1985 • 414 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS

1971 • 409 citations

Noradrenergic axon terminals in the cerebral cortex of rat. III. Topometric ultrastructural analysis

1977 • 396 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex

1989 • 390 citations

Molecular and cellular characterization of the glial roof plate of the spinal cord and optic tectum: A possible role for a proteoglycan in the development of an axon barrier

1990 • 387 citations

Changing role of forebrain astrocytes during development, regenerative failure, and induced regeneration upon transplantation

1986 • 383 citations

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

1988 • 381 citations

Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.

1985 • 374 citations

Ion Channels In Vertebrate Glia

1990 • 373 citations

The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair.

1988 • 362 citations

Diffuse senile plaques occur commonly in the cerebellum in Alzheimer's disease.

1989 • 336 citations

Alterations in L-Glutamate Binding in Alzheimer's and Huntington's Diseases

1985 • 334 citations

Nucleus raphe dorsalis in Alzheimer's disease: Neurofibrillary tangles and loss of large neurons

1985 • 332 citations

Monoamine Innervation of the Cerebral Cortex

1985 • 308 citations

Changes of Biogenic Amines and Their Metabolites in Postmortem Brains from Patients with Alzheimer‐Type Dementia

1984 • 302 citations

Maturation of astrocytes in vitro alters the extent and molecular basis of neurite outgrowth

1990 • 299 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Cortical neuronal counts in normal elderly controls and demented patients

1983 • 293 citations

Dementia of the Alzheimer's Type: Changes in Hippocampal L‐[³H]Glutamate Binding

1987 • 281 citations

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by? protein immunostaining

1988 • 280 citations

Changes in the Monoamine Containing Neurones of the Human Cns in Senile Dementia

1980 • 272 citations

Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys

1973 • 270 citations

Changes in brain gene expression shared by scrapie and Alzheimer disease.

1989 • 253 citations

Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and down's syndrome

1983 • 250 citations

Glycosaminoglycans of brain during development

1975 • 249 citations

Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.

1988 • 244 citations

Aminergic systems in Alzheimer's disease and Parkinson's disease

1987 • 241 citations

Alzheimer's Disease: The Standard Reference

1984 • 240 citations

Proteoglycans: structure and function

1990 • 238 citations

A4 Protein in Alzheimer's Disease: Primary and Secondary Cellular Events in Extracellular Amyloid Deposition

1989 • 236 citations

ACh, substance P and met-enkephalin in the locus coeruleus: Pharmacological evidence for independent sites of action

1979 • 230 citations

Glutamate as transmitter of hippocampal perforant path

1977 • 227 citations

Astrocytes

1989 • 227 citations

Progress in neuropathology

1971 • 225 citations

Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers.

1983 • 224 citations

Sulfated glycosaminoglycans: a common constituent of all amyloids?

1987 • 217 citations

Aspartate and glutamate as possible neurotransmitters in the visual cortex

1981 • 217 citations

Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy

1977 • 215 citations

Neuropeptides in Alzheimer type dementia

1983 • 214 citations

Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses

1989 • 211 citations

Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide.

1987 • 209 citations

Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study.

1970 • 205 citations

Postnatally Induced Formation of the Corpus Callosum in Acallosal Mice on Glia-Coated Cellulose Bridges

1983 • 201 citations

General and dramatic glial reaction in Alzheimer brains

1990 • 193 citations

Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease

1988 • 192 citations

Vasoactive intestinal peptide: A neurotrophic releasing agent and an astroglial mitogen

1990 • 186 citations

Are glial cells targets of the central noradrenergic system? A review of the evidence

1989 • 183 citations

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia^*†

1967 • 179 citations

Glial fibrillary acidic protein and Alzheimer‐type senile dementia

1980 • 176 citations

Long term potentiation in the hippocampus: mechanisms of initiation and modulation by neurotransmitters

1985 • 174 citations

Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques

1983 • 173 citations

Long-term potentiation in the hippocampus

1983 • 167 citations

An overview of current concepts of Alzheimer's disease

1982 • 164 citations

Adrenergic Receptors in Aging and Alzheimer's Disease: Increased β₂‐Receptors in Prefrontal Cortex and Hippocampus

1989 • 162 citations

The autoradiographic localization of L-[3H]glutamate in rat brain tissue

1976 • 160 citations

Fibrous Astrocytes in Senile Dementia of the Alzheimer Type

1981 • 159 citations

Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type

1985 • 157 citations

Effects of Arachidonic Acid on Glutamate and γ‐Aminobutyric Acid Uptake in Primary Cultures of Rat Cerebral Cortical Astrocytes and Neurons

1986 • 153 citations

An immunohistochemical quantification of fibrous astrocytes in the aging human cerebral cortex

1987 • 152 citations

Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study.

1985 • 152 citations

Neurotoxicity of L‐Glutamate and DL‐Threo‐3‐Hydroxyaspartate in the Rat Striatum

1985 • 145 citations

A synthetic peptide as an antagonist of substance P

1981 • 144 citations

Multiple tachykinin receptors

1985 • 142 citations

Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.

1979 • 141 citations

Topographical distribution of neurochemical changes in Alzheimer's disease

1988 • 137 citations

l-Glutamate, excitatory amino acid receptors and brain function

1985 • 135 citations

Glial cell receptors

1988 • 133 citations

Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core.

1981 • 130 citations

A special type of senile plaque, possibly an initial stage

1987 • 129 citations

The Influence of Glycosaminoglycans on the Formation of Fibers from Monomeric Tropocollagen in vitro

1973 • 128 citations

Excitatory amino acids and anoxic/ischaemic brain damage

1985 • 118 citations

The release of endogenous amino acids from the rat visual cortex.

1976 • 116 citations

Ultrastructural localization of β-adrenergic receptor-like immunoreactivity in the cortex and neostriatum of rat brain

1987 • 115 citations

Astrocyte-polymer implants promote regeneration of dorsal root fibers into the adult mammalian spinal cord

1990 • 112 citations

Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus

1983 • 110 citations

Is Alzheimer's disease an anterograde degeneration, originating in the brainstem, and disrupting metabolic and functional interactions between neurons and glial cells?

1989 • 108 citations

Astrocytes and the plaques of Alzheimer's disease

1990 • 105 citations

Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders.

1986 • 105 citations

Decreased Computerized Tomography Numbers in Patients With Presenile Dementia

1980 • 102 citations

Neurotransmitter and Receptor Deficits in Senile Dementia of the Alzheimer Type

1986 • 100 citations

Tachykinin Receptors of the NK1 Type (Substance P) Coupled Positively to Phospholipase C on Cortical Astrocytes from the Newborn Mouse in Primary Culture

1989 • 100 citations

Effects of Neurotransmitters on Astrocyte Glycogen Stores In Vitro

1988 • 99 citations

Sulfated glycosaminoglycans in Alzheimer's disease

1987 • 98 citations

CHEMICAL STUDIES ON ALZHEIMERʼS DISEASE

1965 • 96 citations

Regulation of glycogenolysis by neurotransmitters in the central nervous system

1988 • 94 citations

Changes in the regional brain histamine and histidine levels in postmortem brains of Alzheimer patients

1989 • 93 citations

Alzheimer's disease: Mismatch between amyloid plaques and neuritic plaques

1989 • 93 citations

Use of computerized tomography in senile dementia.

1975 • 92 citations

The protective influence of the locus ceruleus on the blood‐brain barrier

1984 • 91 citations

Evidence for the existence of α- and β-adrenoceptors on cultured glial cells—an electrophysiological study

1982 • 91 citations

Interactions of asymmetric forms of acetylcholinesterase with basement membrane components.

1983 • 91 citations

Degeneration of cholinergic neurons in the basal nucleus following kainic or N-methyl-D-aspartic acid application to the cerebral cortex in the rat

1985 • 90 citations

Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease

1989 • 90 citations

Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type

1983 • 87 citations

Substance P‐like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

1987 • 86 citations

Neuropeptidergic Systems in Plaques of Alzheimerʼs Disease

1987 • 84 citations

Glutamate in cortical fibers.

1981 • 83 citations

An overview of light and electron microscopic changes.

1983 • 81 citations

Rat 3‐Hydroxyanthranilic Acid Oxygenase: Purification from the Liver and Immunocytochemical Localization in the Brain

1987 • 80 citations

Widespread expression of amyloid beta-protein precursor gene in rat brain.

1989 • 78 citations

Chapter 45 Transplantation of immature and mature astrocytes and their effect on scar formation in the lesioned central nervous system

1988 • 76 citations

The ultrastructural localization of sulfated proteoglycans is identical in the amyloids of Alzheimer's disease and AA, AL, senile cardiac and medullary carcinoma-associated amyloidosis

1989 • 75 citations

ROLE OF ASTROCYTES IN COMPARTMENTATION OF AMINO ACID AND ENERGY METABOLISM

1986 • 75 citations

Developmental Change in the Glycosaminoglycan Composition of the Rat Brain

1986 • 73 citations

Role of microglia in plaque formation in senile dementia of the Alzheimer type

1986 • 68 citations

Cloning of a Gene Whose Expression Is Increased in Scrapie and in Senile Plaques in Human Brain

1985 • 68 citations

The cortex of the primary auditory area in Alzheimer's disease

1986 • 67 citations

Regulation of glutamate and GABA transport by adrenoceptors in primary astroglial cell cultures

1989 • 67 citations

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1989 • 67 citations

Serotonin receptors on astrocytes in primary cultures: Effects of methysergide and fluoxetine

1979 • 67 citations

α₁ and α₂ Adrenergic receptors in mouse brain astrocytes from primary cultures

1981 • 66 citations

Changes in β‐Adrenergic Receptor Subtypes in Alzheimer‐Type Dementia

1987 • 65 citations

A synaptic vesicle antigen is restricted to the junctional region of the presynaptic plasma membrane.

1983 • 64 citations

Heparin-polypeptide interactions in aqueous solution

1973 • 63 citations

Substance P and somatostatin coexist within neuritic plaques: Implications for the pathogenesis of Alzheimer's disease

1989 • 62 citations

Identification of the beta adrenergic receptor subtype on astroglia purified from rat brain.

1982 • 62 citations

Substance P immunoreactive astrocytes are present in multiple sclerosis plaques

1989 • 60 citations

Astroglial ablation prevents MPTP-induced nigrostriatal neuronal death

1990 • 60 citations

Regulation of Glycogen Metabolism in Primary and Transformed Astrocytes In Vitro

1983 • 59 citations

Positron emission computed tomography in the diagnosis of dementia.

1981 • 56 citations

The molecular pathogenesis of astrogliosis in scrapie and Alzheimer's disease

1987 • 55 citations

Monosodium glutamate: increased neurotoxicity after removal of neuronal re-uptake sites

1981 • 54 citations

AMINO ACID UPTAKE

1986 • 52 citations

Serum and Cerebrospinal Fluid Proteins and the Blood-Brain Barrier in Alzheimer’s Disease and Multi-Infarct Dementia

1987 • 47 citations

Enzyme-linked immunosorbent assay for human autoantibody to glial fibrillary acidic protein: higher titer of the antibody is detected in serum of patients with Alzheimer's disease

1989 • 44 citations

Unilateral Creutzfeldt‐Jakob disease

1986 • 44 citations

The Amyloid P‐Component (Protein AP): an Integral Part of the Amyloid Substance?

1979 • 43 citations

Neuropeptides in Alzheimer's disease.

1987 • 39 citations

Decreased Computerized Tomography Numbers in Patients with Presenile Dementia

1981 • 38 citations

Substance P and the novel mammalian tachykinins: a diversity of receptors and cellular actions

1985 • 38 citations

Brain Imaging: Aging and Dementia

1984 • 38 citations

Cerebrovascular permeability to horseradish peroxidase in hypertensive rats: effects of unilateral locus ceruleus lesion

1987 • 34 citations

Interaction of plasma fibronectin with selected cryoglobulins.

1980 • 30 citations

Substance P Immunoreactivity in Alzheimer Disease

1990 • 30 citations

Marked Regional Heterogeniety of ¹²⁵I‐Bolton Hunter Substance P Binding and Substance P‐Induced Activation of Phospholipase C in Astrocyte Cultures from the Embryonic or Newborn Rat

1990 • 30 citations

Phenylethanolamine N‐methyltransferase activity is decreased in Alzheimer's disease brains

1987 • 29 citations

Metabolism of Glutamate and Glutamine in Neurons and Astrocytes in Primary Cultures

2018 • 27 citations

Alzheimer'S disease: Monoamines and spiperone binding reduced in nucleus basalis

1986 • 26 citations

Astrocyte mitogenic activity in aged normal and Alzheimer's human brain

1987 • 24 citations

On the possible relationship of cortical microvascular pathology to blood brain barrier changes in Alzheimer's disease

1988 • 24 citations

Increase of substance P-like immunoreactivity in the peripheral nerve of the axolotl after injury

1987 • 21 citations

Uptake and Release of Glutamate and Glutamine in Neurons and Astrocytes in Primary Cultures

2018 • 18 citations

Synaptic transmission in suprasylvian visual cortex is reduced by excitatory amino acid antagonists

1981 • 17 citations

On the Possible Involvement of Sulphomucopolysaccharides in the Storage of Catecholamines within the Central Nervous System

1975 • 14 citations

Qualitative and Quantitative Comparison of Brain Proteins in Alzheimer᾿s Disease

1989 • 14 citations

Substance P Stimulates Release of Arachidonic Acid Cyclooxygenation Products from Primary Culture Rat Astrocytes

1988 • 14 citations

Histochemical demonstration of cytoplasmic glycosaminoglycans in the macroneurons of the human central nervous system

1984 • 14 citations

Alzheimer's disease

1986 • 12 citations

Astrocyte RNA in relation to neuronal RNA depletion in Alzheimer's disease

1988 • 10 citations

[Alzheimer's disease: the glial reaction is general and severe in all areas of the central nervous system].

1989 • 6 citations

Glycosaminoglycans in Synaptosomes

1978 • 4 citations

An introduction to exocytotic release from nerve terminals.

1987 • 1 citations