The role of transmembrane domains in membrane fusion

Rab proteins as membrane organizers

2001 • 3,320 citations

SNAREs — engines for membrane fusion

2006 • 2,509 citations

Membrane Fusion

1990 • 2,458 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

The Mechanisms of Vesicle Budding and Fusion

2004 • 1,738 citations

How proteins produce cellular membrane curvature

2005 • 1,223 citations

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

1998 • 1,032 citations

Rabs and their effectors: Achieving specificity in membrane traffic

2006 • 990 citations

Protein-Lipid Interplay in Fusion and Fission of Biological Membranes

2003 • 741 citations

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

2000 • 692 citations

Lipid–protein interactions in double-layered two-dimensional AQP0 crystals

2005 • 655 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

2001 • 513 citations

Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion

1994 • 485 citations

Three modes of synaptic vesicular recycling revealed by single-vesicle imaging

2003 • 457 citations

Vesicle tethering complexes in membrane traffic

2002 • 456 citations

Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine.

1995 • 455 citations

A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis

2006 • 454 citations

Stalk Model of Membrane Fusion: Solution of Energy Crisis

2002 • 425 citations

High calcium concentrations shift the mode of exocytosis to the kiss-and-run mechanism

1999 • 414 citations

Single synaptic vesicles fusing transiently and successively without loss of identity

2003 • 414 citations

A Thermodynamic Scale for the .beta.-Sheet Forming Tendencies of the Amino Acids

1994 • 391 citations

The Many Mechanisms of Viral Membrane Fusion Proteins

2004 • 384 citations

Membrane Hemifusion: Crossing a Chasm in Two Leaps

2005 • 370 citations

Reconstitution of Ca ²⁺ -Regulated Membrane Fusion by Synaptotagmin and SNAREs

2004 • 369 citations

A Clamping Mechanism Involved in SNARE-Dependent Exocytosis

2006 • 363 citations

Unveiling the Mechanisms of Cell-Cell Fusion

2005 • 348 citations

Conformational change and protein–protein interactions of the fusion protein of Semliki Forest virus

2004 • 348 citations

Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers.

1996 • 341 citations

Transmembrane Segments of Syntaxin Line the Fusion Pore of Ca ² +-Triggered Exocytosis

2004 • 341 citations

The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling.

1995 • 338 citations

SNARE Interactions Are Not Selective

1999 • 322 citations

Mixed and Non-cognate SNARE Complexes

1999 • 319 citations

Inhibition of SNARE Complex Assembly Differentially Affects Kinetic Components of Exocytosis

1999 • 319 citations

The 25 kDa synaptosomal-associated protein SNAP-25 is the major methionine-rich polypeptide in rapid axonal transport and a major substrate for palmitoylation in adult CNS

1992 • 314 citations

The Energetics of Membrane Fusion from Binding, through Hemifusion, Pore Formation, and Pore Enlargement

2004 • 308 citations

A conserved domain is present in different families of vesicular fusion proteins: A new superfamily

1997 • 308 citations

Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles

2006 • 302 citations

Observation of a Membrane Fusion Intermediate Structure

2002 • 298 citations

Close Is Not Enough

2000 • 294 citations

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function

2000 • 288 citations

Lipid Intermediates in Membrane Fusion: Formation, Structure, and Decay of Hemifusion Diaphragm

2002 • 279 citations

Synaptic transmission deficits in Caenorhabditis elegans synaptobrevin mutants.

1998 • 266 citations

Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet

2002 • 265 citations

Fusion of Cells by Flipped SNAREs

2003 • 248 citations

v-SNAREs control exocytosis of vesicles from priming to fusion

2005 • 243 citations

Conformational transition of amyloid β-peptide

2005 • 242 citations

The hemifusion intermediate and its conversion to complete fusion: regulation by membrane composition

1995 • 241 citations

Vesicle-associated membrane protein and synaptophysin are associated on the synaptic vesicle.

1994 • 240 citations

Vacuole Fusion at a Ring of Vertex Docking Sites Leaves Membrane Fragments within the Organelle

2002 • 232 citations

Hemifusion in SNARE-mediated membrane fusion

2005 • 231 citations

TheCaenorhabditis elegans unc-64Locus Encodes a Syntaxin That Interacts Genetically with Synaptobrevin

1998 • 223 citations

Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I

2006 • 222 citations

Interdependent assembly of specific regulatory lipids and membrane fusion proteins into the vertex ring domain of docked vacuoles

2004 • 219 citations

Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

2002 • 217 citations

Yeast Homotypic Vacuole Fusion: A Window on Organelle Trafficking Mechanisms

2000 • 214 citations

Long coiled-coil proteins and membrane traffic

2003 • 212 citations

Determinants of liposome fusion mediated by synaptic SNARE proteins

2004 • 211 citations

Three SNARE complexes cooperate to mediate membrane fusion

2001 • 202 citations

The Transmembrane Domain of Influenza Hemagglutinin Exhibits a Stringent Length Requirement to Support the Hemifusion to Fusion Transition

2000 • 199 citations

SNAREs Contribute to the Specificity of Membrane Fusion

2000 • 198 citations

Intrinsic β-sheet propensities result from van der Waals interactions between side chains and the local backbone

1999 • 194 citations

Equivalent Effects of Snake PLA2 Neurotoxins and Lysophospholipid-Fatty Acid Mixtures

2005 • 188 citations

Membrane fusion: a structural perspective on the interplay of lipids and proteins

2003 • 184 citations

SNARE complexes and neuroexocytosis: how many, how close?

2005 • 181 citations

Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion

2005 • 175 citations

Single Molecule Observation of Liposome-Bilayer Fusion Thermally Induced by Soluble N-Ethyl Maleimide Sensitive-Factor Attachment Protein Receptors (SNAREs)

2004 • 167 citations

Imaging single membrane fusion events mediated by SNARE proteins

2004 • 164 citations

Inner but Not Outer Membrane Leaflets Control the Transition from Glycosylphosphatidylinositol-anchored Influenza Hemagglutinin-induced Hemifusion to Full Fusion

1997 • 153 citations

SNARE-Driven, 25-Millisecond Vesicle Fusion In Vitro

2005 • 148 citations

The Vtc proteins in vacuole fusion: coupling NSF activity to V₀trans-complex formation

2002 • 147 citations

Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation

2004 • 142 citations

SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles

2005 • 141 citations

Neuronal SNAREs Do Not Trigger Fusion between Synthetic Membranes but Do Promote PEG-Mediated Membrane Fusion

2005 • 140 citations

The transmembrane domain in viral fusion: Essential role for a conserved glycine residue in vesicular stomatitis virus G protein

1998 • 139 citations

Structural insights into the SNARE mechanism

2003 • 138 citations

Trans-SNARE pairing can precede a hemifusion intermediate in intracellular membrane fusion

2005 • 138 citations

Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing

2005 • 137 citations

Regulation of neuronal SNARE assembly by the membrane

2003 • 136 citations

SNAREs can promote complete fusion and hemifusion as alternative outcomes

2005 • 133 citations

Vesicle-associated membrane protein-2 (synaptobrevin-2) forms a complex with synaptophysin

1995 • 132 citations

Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity

2001 • 132 citations

A Conserved Membrane-spanning Amino Acid Motif Drives Homomeric and Supports Heteromeric Assembly of Presynaptic SNARE Proteins

2000 • 132 citations

The molecular machinery of synaptic vesicle exocytosis

2003 • 127 citations

Intracellular and viral membrane fusion: a uniting mechanism

2004 • 126 citations

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion

2000 • 120 citations

Amino Acid Sequence Requirements of the Transmembrane and Cytoplasmic Domains of Influenza Virus Hemagglutinin for Viable Membrane Fusion

1999 • 117 citations

The Role of the Synaptic Protein SNAP-25 in the Potency of Botulinum Neurotoxin Type A

2001 • 114 citations

Characterization of stable Chinese hamster ovary cells expressing wild-type, secreted, and glycosylphosphatidylinositol-anchored human immunodeficiency virus type 1 envelope glycoprotein

1993 • 113 citations

Secondary Structure, Orientation, Oligomerization, and Lipid Interactions of the Transmembrane Domain of Influenza Hemagglutinin

1999 • 106 citations

Membrane Fusion Mediated by Baculovirus gp64 Involves Assembly of Stable gp64 Trimers into Multiprotein Aggregates

1998 • 102 citations

Principles of Exocytosis and Membrane Fusion

2004 • 100 citations

SNAP-23 and SNAP-25 Are Palmitoylatedin Vivo

1999 • 98 citations

Diacylglycerol and Its Formation by Phospholipase C Regulate Rab- and SNARE-dependent Yeast Vacuole Fusion

2004 • 98 citations

A Point Mutation in the Transmembrane Domain of the Hemagglutinin of Influenza Virus Stabilizes a Hemifusion Intermediate That Can Transit to Fusion

2000 • 97 citations

The Lipid-anchored Ectodomain of Influenza Virus Hemagglutinin (GPI-HA) Is Capable of Inducing Nonenlarging Fusion Pores

2000 • 96 citations

Mutations in the membrane-spanning domain of the human immunodeficiency virus envelope glycoprotein that affect fusion activity

1994 • 94 citations

Class I and class II viral fusion protein structures reveal similar principles in membrane fusion (Review)

2004 • 90 citations

Vac8p release from the SNARE complex and its palmitoylation are coupled and essential for vacuole fusion

2001 • 89 citations

A stable interaction between syntaxin 1a and synaptobrevin 2 mediated by their transmembrane domains

1999 • 89 citations

Pulmonary surfactant‐associated polypeptide C in a mixed organic solvent transforms from a monomeric α‐helical state into insoluble β‐sheet aggregates

1998 • 86 citations

Viral fusion proteins: multiple regions contribute to membrane fusion

2003 • 84 citations

Influence of membrane anchoring and cytoplasmic domains on the fusogenic activity of vesicular stomatitis virus glycoprotein G

1997 • 77 citations

De novo design of conformationally flexible transmembrane peptides driving membrane fusion

2004 • 77 citations

Expression and characterization of glycophospholipid-anchored human immunodeficiency virus type 1 envelope glycoproteins

1993 • 75 citations

Conformation of the synaptobrevin transmembrane domain

2006 • 71 citations

Role of the Specific Amino Acid Sequence of the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 in Membrane Fusion

2005 • 71 citations

Membrane Structures of the Hemifusion-Inducing Fusion Peptide Mutant G1S and theFusion-Blocking Mutant G1V of Influenza Virus HemagglutininSuggest a Mechanism for Pore Opening in MembraneFusion

2005 • 70 citations

Reversible Merger of Membranes at the Early Stage of Influenza Hemagglutinin-mediated Fusion

2000 • 70 citations

The C- and the N-terminal Regions of Glycoprotein 41 Ectodomain Fuse Membranes Enriched and Not Enriched with Cholesterol, Respectively

2004 • 69 citations

The Transmembrane Domain and Cytoplasmic Tail of Herpes Simplex Virus Type 1 Glycoprotein H Play a Role in Membrane Fusion

2002 • 68 citations

Mutations in the Transmembrane Domain of the HN Protein of Newcastle Disease Virus Affect the Structure and Activity of the Protein

1993 • 68 citations

Structure, dynamics and function of the outer membrane protein A (OmpA) and influenza hemagglutinin fusion domain in detergent micelles by solution NMR

2003 • 68 citations

Sphingomyelin-enriched microdomains define the efficiency of native Ca2+-triggered membrane fusion

2006 • 65 citations

Fluorescence Resonance Energy Transfer Detection of Synaptophysin I and Vesicle-associated Membrane Protein 2 Interactions during Exocytosis from Single Live Synapses

2002 • 65 citations

Transition from hemifusion to pore opening is rate limiting for vacuole membrane fusion

2005 • 63 citations

Regulated secretion: SNARE density, vesicle fusion and calcium dependence

2003 • 59 citations

Membrane-induced conformational change during the activation of HIV-1 gp41 1 1Edited by A. R. Fersht

2000 • 59 citations

Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins

2003 • 58 citations

Modification of the Cytoplasmic Domain of Influenza Virus Hemagglutinin Affects Enlargement of the Fusion Pore

2000 • 54 citations

Palmitoylation determines the function of Vac8 at the yeast vacuole

2006 • 54 citations

The Role of the Membrane-spanning Domain Sequence in Glycoprotein-mediated Membrane Fusion

1999 • 53 citations

Palmitoylation, Membrane-Proximal Basic Residues, and Transmembrane Glycine Residues in the Reovirus p10 Protein Are Essential for Syncytium Formation

2003 • 52 citations

Synaptobrevin Transmembrane Domain DimerizationRevisited

2004 • 52 citations

Computation and mutagenesis suggest a right‐handed structure for the synaptobrevin transmembrane dimer

2001 • 52 citations

Hydrogen Exchange-Mass Spectrometry Analysis of β-Amyloid Peptide Structure

2003 • 50 citations

Ca ²⁺ /calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers

2004 • 50 citations

Mutational Analysis of Synaptobrevin Transmembrane Domain Oligomerization

2002 • 48 citations

Glycoprotein Incorporation and HIV-1 Infectivity Despite Exchange of the gp160 Membrane-Spanning Domain

1996 • 48 citations

Peptide Mimics of the Vesicular Stomatitis Virus G-protein Transmembrane Segment Drive Membrane Fusion in Vitro

2001 • 48 citations

VSV Transmembrane Domain (TMD) Peptide Promotes PEG-Mediated Fusion of Liposomes in a Conformationally Sensitive Fashion

2002 • 47 citations

Influence of glycine residues on peptide conformation in membran environments

1992 • 44 citations

Measles Virus Fusion Protein Is Palmitoylated on Transmembrane-Intracytoplasmic Cysteine Residues Which Participate in Cell Fusion

1998 • 43 citations

Interactions between the Transmembrane Segments of the Alphavirus E1 and E2 Proteins Play a Role in Virus Budding and Fusion

2003 • 42 citations

The SNARE Ykt6 is released from yeast vacuoles during an early stage of fusion

2005 • 39 citations

Direct Evidence that the N-Terminal Heptad Repeat of Sendai Virus Fusion Protein Participates in Membrane Fusion

1999 • 39 citations

New insights into the mechanism of virus-induced membrane fusion

2002 • 38 citations

Side‐chain entropy effects on protein secondary structure formation

2005 • 37 citations

Palmitoylation Plays a Role in Targeting Vac8p to Specific Membrane Subdomains

2006 • 35 citations

Alternate Interfaces May Mediate Homomeric and Heteromeric Assembly in the Transmembrane Domains of SNARE Proteins

2006 • 34 citations

SNARE Assembly and Membrane Fusion, a Kinetic Analysis

2004 • 33 citations

The Polybasic Juxtamembrane Region of Sso1p Is Required for SNARE Function In Vivo

2005 • 28 citations

Mutations of Conserved Glycine Residues within the Membrane-Spanning Domain of Human Immunodeficiency Virus Type 1 gp41 Can Inhibit Membrane Fusion and Incorporation of Env onto Virions

2006 • 25 citations

Analysis of the role of the membrane-spanning and cytoplasmic tail domains of herpes simplex virus type 1 glycoprotein D in membrane fusion

2003 • 20 citations

Transmembrane Organization of Yeast Syntaxin-Analogue Sso1p

2006 • 20 citations

Role of the Vam3p Transmembrane Segment in Homodimerization and SNARE Complex Formation

2006 • 16 citations

The conserved glycine residues in the transmembrane domain of the Semliki Forest virus fusion protein are not required for assembly and fusion

2004 • 11 citations

A model for structural similarity between SNARE complexes based on sequence relationships

1998 • 1 citations