The Transmembrane Domain of Influenza Hemagglutinin Exhibits a Stringent Length Requirement to Support the Hemifusion to Fusion Transition

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

2013 • 2,950 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Structure of influenza haemagglutinin at the pH of membrane fusion

1994 • 1,546 citations

GPI-anchored proteins are organized in submicron domains at the cell surface

1998 • 1,207 citations

A spring-loaded mechanism for the conformational change of influenza hemagglutinin

1993 • 854 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

Interaction of influenza virus haemagglutinin with sphingolipid-cholesterol membrane domains via its transmembrane domain

1997 • 644 citations

VIRUS-CELL AND CELL-CELL FUSION

1996 • 559 citations

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking

1998 • 555 citations

The synaptic SNARE complex is a parallel four-stranded helical bundle

1998 • 497 citations

Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion

1994 • 485 citations

Coiled Coils in Both Intracellular Vesicle and Viral Membrane Fusion

1998 • 412 citations

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (Review)

1999 • 392 citations

The Pathway of Membrane Fusion Catalyzed by Influenza Hemagglutinin: Restriction of Lipids, Hemifusion, and Lipidic Fusion Pore Formation

1998 • 359 citations

Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers.

1996 • 341 citations

Biomembrane fusion: a new concept derived from model studies using two interacting planar lipid bilayers

1987 • 295 citations

Close Is Not Enough

2000 • 294 citations

N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA ₂ subunit to form an N cap that terminates the triple-stranded coiled coil

1999 • 284 citations

Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin.

1987 • 280 citations

Induction of Nonbilayer Structures in Diacylphosphatidylcholine Model Membranes by Transmembrane α-Helical Peptides: Importance of Hydrophobic Mismatch and Proposed Role of Tryptophans

1996 • 266 citations

GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes.

1995 • 227 citations

TheCaenorhabditis elegans unc-64Locus Encodes a Syntaxin That Interacts Genetically with Synaptobrevin

1998 • 223 citations

Dilation of the influenza hemagglutinin fusion pore revealed by the kinetics of individual cell-cell fusion events.

1996 • 210 citations

Mutations in the Middle of the Transmembrane Domain Reverse the Polarity of Transport of the Influenza Virus Hemagglutinin in MDCK Epithelial Cells

1998 • 192 citations

Fusion of influenza hemagglutinin-expressing fibroblasts with glycophorin-bearing liposomes: role of hemagglutinin surface density

1990 • 175 citations

A Specific Point Mutant at Position 1 of the Influenza Hemagglutinin Fusion Peptide Displays a Hemifusion Phenotype

1999 • 172 citations

Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin

1995 • 170 citations

Membrane events involved in myoblast fusion.

1979 • 161 citations

Membrane fusion during secretion. A hypothesis based on electron microscope observation of Phytophthora Palmivora zoospores during encystment.

1977 • 157 citations

Inner but Not Outer Membrane Leaflets Control the Transition from Glycosylphosphatidylinositol-anchored Influenza Hemagglutinin-induced Hemifusion to Full Fusion

1997 • 153 citations

The transmembrane domain in viral fusion: Essential role for a conserved glycine residue in vesicular stomatitis virus G protein

1998 • 139 citations

Arrangement of Subunits in 20 S Particles Consisting of NSF, SNAPs, and SNARE Complexes

1998 • 130 citations

The membrane topology of the fusion peptide region of influenza hemagglutinin determined by spin-labeling EPR

1997 • 126 citations

Low-pH induced conformational changes in viral fusion proteins: implications for the fusion mechanism

1995 • 123 citations

Effect of the N-terminal glycine on the secondary structure, orientation, and interaction of the influenza hemagglutinin fusion peptide with lipid bilayers

1996 • 119 citations

Amino Acid Sequence Requirements of the Transmembrane and Cytoplasmic Domains of Influenza Virus Hemagglutinin for Viable Membrane Fusion

1999 • 117 citations

Heterologous transmembrane and cytoplasmic domains direct functional chimeric influenza virus hemagglutinins into the endocytic pathway.

1986 • 114 citations

The exocytotic fusion pore modeled as a lipidic pore

1992 • 112 citations

Structural characterization of viral fusion proteins

1995 • 110 citations

Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin.

1986 • 108 citations

Secondary Structure, Orientation, Oligomerization, and Lipid Interactions of the Transmembrane Domain of Influenza Hemagglutinin

1999 • 106 citations

Genetic and morphological analyses reveal a critical interaction between the C-termini of two SNARE proteins and a parallel four helical arrangement for the exocytic SNARE complex

1998 • 100 citations

The Lipid-anchored Ectodomain of Influenza Virus Hemagglutinin (GPI-HA) Is Capable of Inducing Nonenlarging Fusion Pores

2000 • 96 citations

The influenza virus hemagglutinin cytoplasmic tail is not essential for virus assembly or infectivity.

1994 • 95 citations

Mutations in the membrane-spanning domain of the human immunodeficiency virus envelope glycoprotein that affect fusion activity

1994 • 94 citations

GPI- and transmembrane-anchored influenza hemagglutinin differ in structure and receptor binding activity

1993 • 91 citations

Specific Single or Double Proline Substitutions in the “Spring-loaded” Coiled-Coil Region of the Influenza Hemagglutinin Impair or Abolish Membrane Fusion Activity

1998 • 90 citations

An osmotic model for the fusion of biological membranes

1986 • 87 citations

A chimeric avian retrovirus containing the influenza virus hemagglutinin gene has an expanded host range

1992 • 77 citations

The Central Proline of an Internal Viral Fusion Peptide Serves Two Important Roles

2000 • 68 citations

Interaction of Mutant Influenza Virus Hemagglutinin Fusion Peptides with Lipid Bilayers: Probing the Role of Hydrophobic Residue Size in the Central Region of the Fusion Peptide

1999 • 62 citations

The Role of the Cytoplasmic Tail Region of Influenza Virus Hemagglutinin in Formation and Growth of Fusion Pores

1997 • 58 citations

Tryptophan-Anchored Transmembrane Peptides Promote Formation of Nonlamellar Phases in Phosphatidylethanolamine Model Membranes in a Mismatch-Dependent Manner

2000 • 57 citations

The Role of the Membrane-spanning Domain Sequence in Glycoprotein-mediated Membrane Fusion

1999 • 53 citations

Meta-stability of the hemifusion intermediate induced by glycosylphosphatidylinositol-anchored influenza hemagglutinin

1997 • 49 citations

The fusion kinetics of influenza hemagglutinin expressing cells to planar bilayer membranes is affected by HA density and host cell surface.

1995 • 49 citations

Fusion Activity of Transmembrane and Cytoplasmic Domain Chimeras of the Influenza Virus Glycoprotein Hemagglutinin

1998 • 43 citations

Hemifusion between Cells Expressing Hemagglutinin of Influenza Virus and Planar Membranes Can Precede the Formation of Fusion Pores that Subsequently Fully Enlarge

1999 • 41 citations

Membrane Fusion: Anchors aweigh

1994 • 21 citations

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