SNAREs — engines for membrane fusion

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

Membrane Fusion

1990 • 2,458 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

THE SYNAPTIC VESICLE CYCLE

2004 • 2,413 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

1980 • 1,808 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

The Mechanisms of Vesicle Budding and Fusion

2004 • 1,738 citations

Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones

1992 • 1,274 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

AAA+ proteins: have engine, will work

2005 • 1,149 citations

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

1998 • 1,032 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

2000 • 783 citations

A conformational switch in syntaxin during exocytosis: role of munc18

1999 • 742 citations

Protein-Lipid Interplay in Fusion and Fission of Biological Membranes

2003 • 741 citations

A genomic perspective on membrane compartment organization

2001 • 693 citations

Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

2000 • 692 citations

SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis

2001 • 669 citations

The molecular machinery for secretion is conserved from yeast to neurons.

1993 • 658 citations

SNAREs and traffic

2005 • 596 citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

1996 • 580 citations

SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

1990 • 578 citations

VAMP-1: a synaptic vesicle-associated integral membrane protein.

1988 • 574 citations

A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast

1989 • 570 citations

Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.

1993 • 540 citations

Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain.

1989 • 513 citations

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

2001 • 513 citations

A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles

1994 • 501 citations

Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release

2001 • 501 citations

Synaptotagmins: Why So Many?

2002 • 497 citations

Targeting Rab GTPases to distinct membrane compartments

2004 • 464 citations

Synaptotagmin: A Ca2+ sensor that triggers exocytosis?

2002 • 464 citations

Homotypic vacuolar fusion mediated by t- and v-SNAREs

1997 • 457 citations

Three-Dimensional Structure of the Complexin/SNARE Complex

2002 • 449 citations

SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis

2001 • 420 citations

SNARE Complex Formation Is Triggered by Ca 2+ and Drives Membrane Fusion

1999 • 415 citations

Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking

1994 • 401 citations

Munc18-1 Promotes Large Dense-Core Vesicle Docking

2001 • 392 citations

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines

2005 • 386 citations

Membrane fusion machinery: Insights from synaptic proteins

1993 • 380 citations

Reconstitution of Ca ²⁺ -Regulated Membrane Fusion by Synaptotagmin and SNAREs

2004 • 369 citations

SNARE Selectivity of the COPII Coat

2003 • 368 citations

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

2003 • 361 citations

Structural Organization of the Synaptic Exocytosis Core Complex

1997 • 352 citations

Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.

1991 • 347 citations

The t-SNAREs syntaxin 1 and SNAP-25 are present on organelles that participate in synaptic vesicle recycling.

1995 • 338 citations

SNARE Interactions Are Not Selective

1999 • 322 citations

Mixed and Non-cognate SNARE Complexes

1999 • 319 citations

Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs

2002 • 309 citations

Structure and function of SNARE and SNARE-interacting proteins

2005 • 307 citations

The v-ATPase V 0 Subunit a1 Is Required for a Late Step in Synaptic Vesicle Exocytosis in Drosophila

2005 • 301 citations

Topological restriction of SNARE-dependent membrane fusion

2000 • 288 citations

A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function

2000 • 288 citations

Vesicle trafficking: pleasure and pain from SM genes

2003 • 280 citations

Folding intermediates of SNARE complex assembly.

1999 • 272 citations

Defects in synaptic vesicle docking in unc-18 mutants

2003 • 263 citations

v-SNAREs control exocytosis of vesicles from priming to fusion

2005 • 243 citations

Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport

1997 • 242 citations

Hemifusion in SNARE-mediated membrane fusion

2005 • 231 citations

Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p

1998 • 221 citations

Characterization of a component of the yeast secretion machinery: identification of the SEC18 gene product.

1988 • 220 citations

Temperature-Sensitive Paralytic Mutations Demonstrate that Synaptic Exocytosis Requires SNARE Complex Assembly and Disassembly

1998 • 217 citations

A Transient N-terminal Interaction of SNAP-25 and Syntaxin Nucleates SNARE Assembly

2004 • 216 citations

Yeast Homotypic Vacuole Fusion: A Window on Organelle Trafficking Mechanisms

2000 • 214 citations

Determinants of liposome fusion mediated by synaptic SNARE proteins

2004 • 211 citations

The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin

1995 • 210 citations

An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes

2001 • 201 citations

SNAREs Contribute to the Specificity of Membrane Fusion

2000 • 198 citations

Vesicular restriction of synaptobrevin suggests a role for calcium in membrane fusion

2002 • 197 citations

SNARE assembly and disassembly exhibit a pronounced hysteresis

2002 • 193 citations

Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation

2005 • 191 citations

SNARE complexes and neuroexocytosis: how many, how close?

2005 • 181 citations

Vacuole membrane fusion

2003 • 179 citations

Measuring Distances in Supported Bilayers by Fluorescence Interference-Contrast Microscopy: Polymer Supports and SNARE Proteins

2003 • 179 citations

Membrane fusion

2002 • 175 citations

Ordering the Final Events in Yeast Exocytosis

2000 • 175 citations

Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles

2004 • 174 citations

Synaptic Core Complex of Synaptobrevin, Syntaxin, and SNAP25 Forms High Affinity -SNAP Binding Site

1995 • 174 citations

The Length of the Flexible SNAREpin Juxtamembrane Region Is a Critical Determinant of SNARE-Dependent Fusion

1999 • 173 citations

Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly.

2000 • 167 citations

A Role of VAMP8/Endobrevin in Regulated Exocytosis of Pancreatic Acinar Cells

2004 • 167 citations

Single Molecule Observation of Liposome-Bilayer Fusion Thermally Induced by Soluble N-Ethyl Maleimide Sensitive-Factor Attachment Protein Receptors (SNAREs)

2004 • 167 citations

Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes

2002 • 166 citations

A targeting signal in VAMP regulating transport to synaptic vesicles

1995 • 166 citations

Imaging single membrane fusion events mediated by SNARE proteins

2004 • 164 citations

Localization, Dynamics, and Protein Interactions Reveal Distinct Roles for ER and Golgi SNAREs

1998 • 161 citations

Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators

2004 • 161 citations

The R-SNARE Endobrevin/VAMP-8 Mediates Homotypic Fusion of Early Endosomes and Late Endosomes

2000 • 156 citations

TheSaccharomyces cerevisiaev-SNARE Vti1p Is Required for Multiple Membrane Transport Pathways to the Vacuole

1999 • 154 citations

The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis

2003 • 153 citations

Homotypic fusion of early endosomes: SNAREs do not determine fusion specificity

2006 • 152 citations

Asymmetric Requirements for a Rab Gtpase and Snare Proteins in Fusion of Copii Vesicles with Acceptor Membranes

2000 • 149 citations

SNARE-Driven, 25-Millisecond Vesicle Fusion In Vitro

2005 • 148 citations

Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation

2001 • 145 citations

Analysis of Sec22p in Endoplasmic Reticulum/Golgi Transport Reveals Cellular Redundancy in SNARE Protein Function

2002 • 144 citations

Homo- and Heterooligomeric SNARE Complexes Studied by Site-directed Spin Labeling

2001 • 143 citations

An Autoinhibitory Mechanism for Nonsyntaxin SNARE Proteins Revealed by the Structure of Ykt6p

2001 • 142 citations

Tracking SNARE Complex Formation in Live Endocrine Cells

2004 • 142 citations

SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles

2005 • 141 citations

A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum

1997 • 141 citations

Neuronal SNAREs Do Not Trigger Fusion between Synthetic Membranes but Do Promote PEG-Mediated Membrane Fusion

2005 • 140 citations

Sequential SNARE Assembly Underlies Priming and Triggering of Exocytosis

2001 • 139 citations

Structural insights into the SNARE mechanism

2003 • 138 citations

Trans-SNARE pairing can precede a hemifusion intermediate in intracellular membrane fusion

2005 • 138 citations

Functions of SNAREs in intracellular membrane fusion and lipid bilayer mixing

2005 • 137 citations

SNAREs can promote complete fusion and hemifusion as alternative outcomes

2005 • 133 citations

SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.

1992 • 133 citations

Peptide mimics of SNARE transmembrane segments drive membrane fusion depending on their conformational plasticity

2001 • 132 citations

A Conserved Membrane-spanning Amino Acid Motif Drives Homomeric and Supports Heteromeric Assembly of Presynaptic SNARE Proteins

2000 • 132 citations

Single-molecule studies of SNARE complex assembly reveal parallel and antiparallel configurations

2003 • 124 citations

Synaptophysin I Controls the Targeting of VAMP2/Synaptobrevin II to Synaptic Vesicles

2003 • 123 citations

Structural Basis for the Inhibitory Role of Tomosyn in Exocytosis

2004 • 120 citations

Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion

2000 • 120 citations

SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs

2002 • 117 citations

Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion

2005 • 116 citations

Membrane Fusion in Eukaryotic Cells

2002 • 116 citations

Membrane Fusion Mediated by Coiled Coils: A Hypothesis

2000 • 115 citations

Structural Analysis of the Neuronal SNARE Protein Syntaxin-1A^,

2000 • 111 citations

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I

2002 • 110 citations

Dsl1p, Tip20p, and the Novel Dsl3(Sec39) Protein Are Required for the Stability of the Q/t-SNARE Complex at the Endoplasmic Reticulum in Yeast

2005 • 108 citations

A Direct Interaction between Cdc42 and Vesicle-associated Membrane Protein 2 Regulates SNARE-dependent Insulin Exocytosis

2004 • 108 citations

A SNARE required for retrograde transport to the endoplasmic reticulum

2003 • 104 citations

Model organisms lead the way to protein palmitoyltransferases

2004 • 100 citations

Yeast Golgi SNARE interactions are promiscuous

2000 • 98 citations

The specificity of SNARE-dependent fusion is encoded in the SNARE motif

2004 • 94 citations

Amisyn, a Novel Syntaxin-binding Protein That May Regulate SNARE Complex Assembly

2002 • 94 citations

A Novel SNARE N-terminal Domain Revealed by the Crystal Structure of Sec22b

2001 • 94 citations

Use1p is a yeast SNARE protein required for retrograde traffic to the ER

2003 • 90 citations

The Di-leucine Motif of Vesicle-associated Membrane Protein 4 Is Required for Its Localization and AP-1 Binding

2001 • 88 citations

Abl Interactor 1 (Abi-1) Wave-Binding and SNARE Domains Regulate Its Nucleocytoplasmic Shuttling, Lamellipodium Localization, and Wave-1 Levels

2004 • 85 citations

Cholesterol-dependent Syntaxin-4 and SNAP-23 Clustering Regulates Caveolar Fusion with the Endothelial Plasma Membrane

2005 • 84 citations

Regulation of SNAREs by tomosyn and ROCK

2004 • 82 citations

A journey from mammals to yeast with vacuolar H+-ATPase (V-ATPase).

2003 • 79 citations

The SNARE Ykt6 mediates protein palmitoylation during an early stage of homotypic vacuole fusion

2003 • 76 citations

Defining the SNARE Complex Binding Surface of α-SNAP

2003 • 76 citations

Self-association of the H3 Region of Syntaxin 1A

2001 • 72 citations

Mechanical Coupling via the Membrane Fusion SNARE Protein Syntaxin 1A: A Molecular Dynamics Study

2003 • 69 citations

Crystal Structure and Biophysical Properties of a Complex between the N-terminal SNARE Region of SNAP25 and Syntaxin 1a

2001 • 66 citations

Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.

1993 • 65 citations

The ionic layer is required for efficient dissociation of the SNARE complex by α-SNAP and NSF

2001 • 61 citations

Targeting of the Synaptic Vesicle Protein Synaptobrevin in the Axon of Cultured Hippocampal Neurons: Evidence for Two Distinct Sorting Steps

1997 • 59 citations

Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins

2003 • 58 citations

Functional Analysis of Conserved Structural Elements in Yeast Syntaxin Vam3p

2001 • 57 citations

Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog

2002 • 51 citations

The Cytoplasmic Domain of Vamp4 and Vamp5 Is Responsible for Their Correct Subcellular Targeting

2003 • 50 citations

The Membrane-Dipped Neuronal SNARE Complex: A Site-Directed Spin Labeling Electron Paramagnetic Resonance Study

2002 • 45 citations

The Four-helix Bundle of the Neuronal Target Membrane SNARE Complex Is Neither Disordered in the Middle nor Uncoiled at the C-terminal Region

2002 • 43 citations

Solution Structure of the Vam7p PX Domain^,

2002 • 36 citations

Thermal Fluctuations of Red Blood Cell Membrane via a Constant-Area Particle-Dynamics Model

2005 • 30 citations

Protein–protein interactions in intracellular membrane fusion

2000 • 29 citations

SNAREs Involved in Traffic through the Golgi Complex

1995 • 22 citations

IMPLICATIONS FOR INTERMEDIATES IN SNARE COMPLEX ASSEMBLY

2001 • 15 citations

An intramolecular t-SNARE complex functions in vivo without the syntaxin NH2-terminal regulatory domain

2006 • 12 citations