Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

1993 • 2,169 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

1987 • 1,243 citations

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 • 1,032 citations

Identification, culture, and characterization of pancreatic stellate cells in rats and humans

1998 • 961 citations

Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture

1998 • 884 citations

Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors

1993 • 656 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis

1999 • 559 citations

Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis

2000 • 463 citations

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

1991 • 461 citations

Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues.

1990 • 428 citations

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

2000 • 426 citations

Activation of Pancreatic Stellate Cells in Human and Experimental Pancreatic Fibrosis

1999 • 396 citations

Maintenance of Differentiated Phenotype of Cultured Rat Hepatic Lipocytes by Basement Membrane Matrix

1989 • 353 citations

Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver

1996 • 349 citations

Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis

1996 • 321 citations

The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

1992 • 268 citations

Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver.

1992 • 207 citations

Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)

1996 • 182 citations

Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen.

1989 • 177 citations

Matrix Metalloproteinase 2 (Gelatinase A) Regulates Glomerular Mesangial Cell Proliferation and Differentiation

1996 • 159 citations

Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo.

1994 • 154 citations

Localization of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis

1995 • 142 citations

MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells

1999 • 137 citations

Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation

1999 • 137 citations

The 28-kDa N-terminal domain of mouse stromelysin-3 has the general properties of a weak metalloproteinase

1993 • 132 citations

Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity

1992 • 131 citations

Connective Tissue Growth Factor Is a Regulator for Fibrosis in Human Chronic Pancreatitis

1999 • 131 citations

Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats.

1992 • 127 citations

Hepatocyte proliferation in primary biliary cirrhosis as assessed by proliferating cell nuclear antigen and Ki-67 antigen labelling

1995 • 127 citations

Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis.

1994 • 90 citations

Enhancement of transforming growth factor β1 expression in the rat pancreas during regeneration from caerulein‐induced pancreatitis

1994 • 88 citations

Transforming Growth Factor-β Regulation of Collagenase, 72Kda-Progelatinase, Timp and Pai-1 Expression in Rat Bone Cell Populations and Human Fibroblasts

1989 • 80 citations

TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro

2000 • 62 citations

Hepatic fibrogenesis: the puzzle of interacting cells, fibrogenic cytokines, regulatory loops, and extracellular matrix molecules.

1992 • 61 citations

Immunohistochemical Study of Transforming Growth Factor-p 1, Matrix Metalloproteinase-2,9, Tissue Inhibitors of Metalloproteinase-1,2, and Basement Membrane Components at Pancreatic Ducts in Chronic Pancreatitis

1998 • 39 citations

Irradiation of Rat Mesangial Cells Alters the Expression of Gene Products Associated with the Development of Renal Fibrosis

1999 • 37 citations

Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells.

1995 • 22 citations

Angiotensin II-Induced Modulation of Rat Mesangial Cell Phenotype

1999 • 7 citations

[Fibrocytes and fibroblasts. Definition and significance in wound healing and fibrotic diseases of the skin].

1989 • 5 citations

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