Expression and transactivating functions of the bZIP transcription factor GADD153 in mammary epithelial cells

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1993 • 884 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis

1997 • 471 citations

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)–ATF composite site to regulate Gadd153 expression during the stress response

1999 • 445 citations

Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor

2000 • 362 citations

Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design.

1993 • 335 citations

TAFs mediate transcriptional activation and promoter selectivity

1996 • 334 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells

1996 • 317 citations

Stress-Induced Binding of the Transcription Factor CHOP to a Novel DNA Control Element

1996 • 305 citations

Analysis of ATF3, a Transcription Factor Induced by Physiological Stresses and Modulated by gadd153/Chop10

1996 • 305 citations

Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland.

1995 • 304 citations

TAFs mediate transcriptional activation and promoter selectivity

1996 • 299 citations

Heregulin Regulates Cytoskeletal Reorganization and Cell Migration through the p21-activated Kinase-1 via Phosphatidylinositol-3 Kinase

1998 • 288 citations

Think globally, act locally: the making of a mouse mammary gland

1998 • 269 citations

Transcriptional control: Versatile molecular glue

1996 • 231 citations

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

1995 • 230 citations

HER‐2/ neu Signal Transduction in Human Breast and Ovarian Cancer

1997 • 227 citations

Regulation of Cyclooxygenase-2 pathway by HER2 receptor

1999 • 226 citations

Contacts in Context: Promoter Specificity and Macromolecular Interactions in Transcription

1996 • 223 citations

BRCA1 Effects on the Cell Cycle and the DNA Damage Response Are Linked to Altered Gene Expression

2000 • 217 citations

gadd153/Chop10, a Potential Target Gene of the Transcriptional Repressor ATF3

1997 • 155 citations

Overexpression of HER2 modulates bcl-2, bcl-XL, and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells.

1996 • 149 citations

Isolation, characterization and chromosomal localization of the human GADD153 gene

1992 • 130 citations

Growth Factors Regulate Heterogeneous Nuclear Ribonucleoprotein K Expression and Function

2001 • 127 citations

Physical and Functional Association between GADD153 and CCAAT/Enhancer-binding Protein β during Cellular Stress

1996 • 113 citations

Differential Effects of Prolactin andsrc/abl Kinases on the Nuclear Translocation of STAT5B and STAT5A

1999 • 113 citations

Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.

1996 • 112 citations

Constitutive Activation of STAT5 by a Point Mutation in the SH2 Domain

2000 • 99 citations

Neu differentiation factor/heregulin modulates growth and differentiation of HC11 mammary epithelial cells.

1995 • 98 citations

Formation of a high affinity heregulin binding site using the soluble extracellular domains of ErbB2 with ErbB3 or ErbB4

1998 • 65 citations

Novel Interaction between the Transcription Factor CHOP (GADD153) and the Ribosomal Protein FTE/S3a Modulates Erythropoiesis

2000 • 54 citations

Dominant-negative Mutants of Grb2 Induced Reversal of the Transformed Phenotypes Caused by the Point Mutation-activated Rat HER-2/Neu

1995 • 51 citations

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

1999 • 39 citations

Evidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells

2000 • 35 citations

Regulation of Elongation Factor-1α Expression by Growth Factors and Anti-receptor Blocking Antibodies

2001 • 28 citations

Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine

1999 • 20 citations

Heregulin induces expression, DNA binding activity, and transactivating functions of basic leucine zipper activating transcription factor 4.

2000 • 19 citations