The distinct role of mGlu1 receptors in post-ischemic neuronal death

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1992 • 2,527 citations

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2000 • 1,197 citations

The changing landscape of ischaemic brain injury mechanisms

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction

1993 • 905 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

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Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Postsynaptic endocannabinoid release is critical to long-term depression in the striatum

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Heterosynaptic LTD of Hippocampal GABAergic Synapses

2003 • 637 citations

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2002 • 586 citations

Presynaptic Inhibition Caused by Retrograde Signal from Metabotropic Glutamate to Cannabinoid Receptors

2001 • 558 citations

The Shank family of scaffold proteins

2000 • 555 citations

Metabotropic Glutamate Receptors 1 and 5 Differentially Regulate CA1 Pyramidal Cell Function

2001 • 433 citations

Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor

2000 • 428 citations

Activation of Metabotropic Glutamate Receptor 5 Has Direct Excitatory Effects and Potentiates NMDA Receptor Currents in Neurons of the Subthalamic Nucleus

2000 • 414 citations

Metabotropic Glutamate Receptors Drive the Endocannabinoid System in Hippocampus

2001 • 406 citations

Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors

2001 • 363 citations

Kainate Receptor Modulation of GABA Release Involves a Metabotropic Function

1998 • 339 citations

γ‐Aminobutyric acid_A neurotransmission and cerebral ischemia

2001 • 317 citations

Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs

2001 • 310 citations

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Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons

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Group I metabotropic glutamate receptors: implications for brain diseases

1999 • 297 citations

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2001 • 236 citations

Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

2002 • 235 citations

Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons

2002 • 217 citations

Localization of mGluR1a-like immunoreactivity and mGluR5-like immunoreactivity in identified populations of striatal neurons

1998 • 215 citations

Synaptic Input of Horizontal Interneurons in Stratum Oriens of the Hippocampal CA1 Subfield: Structural Basis of Feed‐back Activation

1995 • 210 citations

Short-Term Retrograde Inhibition of GABAergic Synaptic Currents in Rat Purkinje Cells Is Mediated by Endogenous Cannabinoids

2002 • 197 citations

Selective mGluR5 antagonists MPEP and SIB‐1893 decrease NMDA or glutamate‐mediated neuronal toxicity through actions that reflect NMDA receptor antagonism

2000 • 194 citations

Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

2001 • 188 citations

Differential Subcellular Localization of mGluR1a and mGluR5 in the Rat and Monkey Substantia Nigra

2001 • 171 citations

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection

1999 • 170 citations

BAY36-7620: A Potent Non-Competitive mGlu1 Receptor Antagonist with Inverse Agonist Activity.

2001 • 166 citations

The inhibitory mGluR agonist, s-4-carboxy-3-hydroxy-phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death

1995 • 165 citations

Selective Blockade of mGlu5 Metabotropic Glutamate Receptors Is Protective against Methamphetamine Neurotoxicity

2002 • 148 citations

Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

2000 • 146 citations

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives

2002 • 145 citations

Protection with metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death: time-course and mechanisms

1999 • 143 citations

Differential Expression of Group I Metabotropic Glutamate Receptors in Functionally Distinct Hippocampal Interneurons

2000 • 142 citations

Mutational Analysis and Molecular Modeling of the Allosteric Binding Site of a Novel, Selective, Noncompetitive Antagonist of the Metabotropic Glutamate 1 Receptor

2003 • 134 citations

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors

1999 • 132 citations

Immunolocalization of metabotropic glutamate receptor 1α (mGluR1α) in distinct classes of interneuron in the CA1 region of the rat hippocampus

2004 • 128 citations

Activation of Group I Metabotropic Glutamate Receptors Produces a Direct Excitation and Disinhibition of GABAergic Projection Neurons in the Substantia Nigra Pars Reticulata

2001 • 125 citations

Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective

2000 • 125 citations

Distinct physiological roles of the Gq‐coupled metabotropic glutamate receptors co‐expressed in the same neuronal populations

2002 • 118 citations

Metabotropic glutamate receptor modulation of voltage-gated Ca2+ channels involves multiple receptor subtypes in cortical neurons

1996 • 118 citations

mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.

2001 • 115 citations

Activation of Metabotropic Glutamate Receptor Subtype mGluR1 Contributes to Post-Traumatic Neuronal Injury

1996 • 114 citations

Evidence for Metabotropic Glutamate Receptor Activation in the Induction of Depolarization-Induced Suppression of Inhibition in Hippocampal CA1

1998 • 111 citations

1‐Aminoindan‐1,5‐dicarboxylic acid and (S)‐(+)‐2‐(3′‐carboxybicyclo[1.1.1] pentyl)‐glycine, two mGlu1 receptor‐preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia

1999 • 110 citations

Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia

2001 • 105 citations

Selective involvement of mGlu1 receptors in corticostriatal LTD

2001 • 102 citations

Selective Blockade of Type-1 Metabotropic Glutamate Receptors Induces Neuroprotection by Enhancing Gabaergic Transmission

2001 • 99 citations

Selective Blockade of the mGluR1 Receptor Reduces Traumatic Neuronal Injury in Vitro and Improves Outcome after Brain Trauma

2001 • 96 citations

Group I Metabotropic Glutamate Receptors in Spinal Cord Injury: Roles in Neuroprotection and the Development of Chronic Central Pain

2002 • 95 citations

Immunohistochemical localization of the mGluR1? metabotropic glutamate receptor in the adult rodent forebrain: Evidence for a differential distribution of mGluR1 splice variants

1998 • 92 citations

Increased Expression of Neuronal Nitric Oxide Synthase Spliced Variants in Reactive Astrocytes of Amyotrophic Lateral Sclerosis Human Spinal Cord

2001 • 91 citations

Coordinate regulation of metabotropic glutamate receptors

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Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures

1998 • 85 citations

Distinct Functional Roles of the Metabotropic Glutamate Receptors 1 and 5 in the Rat Globus Pallidus

2003 • 84 citations

Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro

2000 • 84 citations

Reduced stress‐induced hyperthermia in mGluR5 knockout mice

2002 • 82 citations

Synthesis and biological evaluation of 2-(3′-(1 H -tetrazol-5-yl)bicyclo[1.1.1]pent-1-yl)glycine ( S -TBPG), a novel mGlu1 receptor antagonist

2001 • 75 citations

Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex

1998 • 75 citations

A novel, competitive mGlu₅ receptor antagonist (LY344545) blocks DHPG‐induced potentiation of NMDA responses but not the induction of LTP in rat hippocampal slices

2000 • 73 citations

An activity‐dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

2001 • 73 citations

Differential Roles for mGluR1 and mGluR5 in the Persistent Prolongation of Epileptiform Bursts

2002 • 72 citations

Role of Group I Metabotropic Glutamate Receptors in Traumatic Spinal Cord White Matter Injury

1998 • 71 citations

Neuroprotective and behavioral effects of the selective metabotropic glutamate mGlu1 receptor antagonist BAY 36-7620

2001 • 70 citations

Group I Metabotropic Glutamate Antagonist Reduces Acute Neuronal Degeneration and Behavioral Deficits after Traumatic Brain Injury in Rats

2001 • 68 citations

Differential expression of rat and human type 1 metabotropic glutamate receptor splice variant messenger RNAs

1998 • 67 citations

The Role of Group I and Group II Metabotropic Glutamate Receptors in Modulation of Striatal NMDA and Quinolinic Acid Toxicity

2001 • 62 citations

Rat group I Metabotropic Glutamate Receptors Inhibit Neuronal Ca²⁺Channels via Multiple Signal Transduction Pathways in HEK 293 Cells

1998 • 62 citations

Metabotropic glutamate 1 (mGlu1) receptor antagonists enhance GABAergic neurotransmission: a mechanism for the attenuation of post-ischemic injury and epileptiform activity?

2002 • 61 citations

Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil

2000 • 61 citations

The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons

1998 • 60 citations

The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death

2002 • 59 citations

Regulation of mglu7 receptors by proteins that interact with the intracellular C-terminus

2001 • 57 citations

β-Amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metabotropic glutamate receptors

1999 • 51 citations

Metabotropic and ionotropic transducers of glutamate signal inversely control cytoplasmic Ca2+ concentration and excitotoxicity in cultured cerebellar granule cells: pivotal role of protein kinase C.

1996 • 44 citations

The mGlu receptor ligand (S)-4C3HPG protects neurons after global ischaemia in gerbils

1998 • 44 citations

Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo

2002 • 43 citations

Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons

2002 • 43 citations

Synthesis and pharmacological characterisation of 2,4-Dicarboxy-pyrroles as selective non-Competitive mGluR1 antagonists

2003 • 42 citations

Haloperidol-induced alteration in the physiological actions of group I mGlus in the subthalamic nucleus and the substantia nigra pars reticulata

2002 • 38 citations

Correspondence

1997 • 36 citations

Reversal of glutamate excitotoxicity by activation of PKC-associated metabotropic glutamate receptors in cerebellar granule cells relies on NR2C subunit expression

1999 • 36 citations

Activation of metabotropic glutamate receptor subtype 1/protein kinase C/mitogen-activated protein kinase pathway is required for postischemic long-term potentiation in the striatum.

2001 • 36 citations

Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region

1999 • 34 citations

Exacerbation of Neuronal Cell Death by Activation of Group I Metabotropic Glutamate Receptors: Role of NMDA Receptors and Arachidonic Acid Release

2001 • 32 citations

Immunolocalization of mGluR1α in specific populations of local circuit neurons in the cerebral cortex

2000 • 25 citations

(S)-4C3HPG reduces infarct size after focal cerebral ischemia

1998 • 18 citations