The Dileucine-Based Sorting Motif in HIV-1 Nef Is Not Required for Down-Regulation of Class I MHC

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1996 • 1,041 citations

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1991 • 760 citations

Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1994 • 701 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

Linking cargo to vesicle formation: receptor tail interactions with coat proteins

1997 • 408 citations

Nef Interacts with the μ Subunit of Clathrin Adaptor Complexes and Reveals a Cryptic Sorting Signal in MHC I Molecules

1998 • 383 citations

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

1998 • 372 citations

A novel Sec-independent periplasmic protein translocation pathway in Escherichia coli

1998 • 372 citations

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene

1994 • 372 citations

The CD4 Determinant for Downregulation by HIV-1 Nef Directly Binds to Nef. Mapping of the Nef Binding Surface by NMR

1996 • 347 citations

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

1998 • 307 citations

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

1998 • 273 citations

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1998 • 232 citations

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

1998 • 227 citations

A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway

1995 • 219 citations

An acidic sequence within the cytoplasmic domain of furin functions as a determinant of trans-Golgi network localization and internalization from the cell surface.

1995 • 215 citations

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the chain of adaptor complexes

1998 • 209 citations

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1997 • 206 citations

Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein

1996 • 202 citations

A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease

1994 • 63 citations

Virological Importance of the Protease-Cleavage Site in Human Immunodeficiency Virus Type 1 Nef Is Independent of both Intravirion Processing and CD4 Down-regulation

1998 • 25 citations