Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
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References (72)
UCSF Chimera—A visualization system for exploratory research and analysis
2004 • 42,136 citations
Gene Ontology: tool for the unification of biology
2000 • 38,297 citations
dbSNP: the NCBI database of genetic variation
2001 • 6,995 citations
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 • 4,789 citations
EGFRMutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
2005 • 3,807 citations
Drug repositioning: identifying and developing new uses for existing drugs
2004 • 2,868 citations
Oxidative stress as a mediator of apoptosis
1994 • 2,210 citations
Relating protein pharmacology by ligand chemistry
2007 • 1,915 citations
Predicting new molecular targets for known drugs
2009 • 1,599 citations
11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study)
2009 • 1,305 citations
The Universal Protein Resource (UniProt) in 2010
2009 • 1,236 citations
Drug Target Identification Using Side-Effect Similarity
2008 • 1,200 citations
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
2005 • 1,184 citations
DOCK 4.0: search strategies for automated molecular docking of flexible molecule databases.
2001 • 1,132 citations
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
2009 • 998 citations
Clozapine-Induced Agranulocytosis -- Incidence and Risk Factors in the United States
1993 • 948 citations
The Universal Protein Resource (UniProt) in 2010
2010 • 943 citations
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
2010 • 862 citations
Target identification using drug affinity responsive target stability (DARTS)
2009 • 840 citations
Discovery of drug mode of action and drug repositioning from transcriptional responses
2010 • 803 citations
γ-Tocopherol, the major form of vitamin E in the US diet, deserves more attention
2001 • 757 citations
TTD: Therapeutic Target Database
2002 • 635 citations
Human protein reference database--2006 update
2005 • 605 citations
Protein promiscuity and its implications for biotechnology
2009 • 474 citations
Network analyses in systems pharmacology
2009 • 458 citations
Regulation of genes encoding NAD(P)H:quinone oxidoreductases
2000 • 419 citations
Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target
2010 • 390 citations
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
2007 • 377 citations
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
2010 • 375 citations
Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis
2007 • 361 citations
Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets
2010 • 333 citations
Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity
2008 • 317 citations
Identifying the proteins to which small-molecule probes and drugs bind in cells
2009 • 307 citations
Elucidating mechanisms of drug-induced toxicity
2005 • 303 citations
Idiosyncratic Drug Reactions: Current Understanding
2006 • 287 citations
PDTD: a web-accessible protein database for drug target identification
2008 • 274 citations
Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses
2009 • 258 citations
Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model
2010 • 205 citations
Clozapine-induced agranulocytosis
1977 • 173 citations
Delayed drug hypersensitivity: models of T‐cell stimulation
2010 • 156 citations
Structure‐Based Approaches to Target Fishing and Ligand Profiling
2010 • 145 citations
Specific Binding of Aminoglycosides to a Human rRNA Construct Based on a DNA Polymorphism Which Causes Aminoglycoside-Induced Deafness
1997 • 142 citations
Drug Hypersensitivity Reactions: Pathomechanism and Clinical Symptoms
2010 • 135 citations
Induction of Metabolism-Dependent and -Independent Neutrophil Apoptosis by Clozapine
2000 • 131 citations
Role of systems pharmacology in understanding drug adverse events
2010 • 128 citations
Idiosyncratic drug‐induced agranulocytosis: Possible mechanisms and management
2009 • 119 citations
Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.
1997 • 111 citations
Ligand-Target Prediction Using Winnow and Naive Bayesian Algorithms and the Implications of Overall Performance Statistics
2008 • 104 citations
Harvesting Candidate Genes Responsible for Serious Adverse Drug Reactions from a Chemical-Protein Interactome
2009 • 98 citations
Multiple Active Site Corrections for Docking and Virtual Screening
2003 • 96 citations
In Silico Elucidation of the Molecular Mechanism Defining the Adverse Effect of Selective Estrogen Receptor Modulators
2007 • 86 citations
Adverse Effects of Atypical Antipsychotics in the Elderly
2006 • 78 citations
Generating Genome-Scale Candidate Gene Lists for Pharmacogenomics
2009 • 78 citations
A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir
2007 • 75 citations
Tumor Necrosis Factor Constellation Polymorphism and Clozapine-Induced Agranulocytosis in Two Different Ethnic Groups
1997 • 72 citations
Binding of Protein Kinase Inhibitors to Synapsin I Inferred from Pair-Wise Binding Site Similarity Measurements
2010 • 66 citations
The major histocompatibility complex region marked by HSP70-1 and HSP70- 2 variants is associated with clozapine-induced agranulocytosis in two different ethnic groups
1995 • 65 citations
Impact of Myeloperoxidase and NADPH-Oxidase Polymorphisms in Drug-Induced Agranulocytosis
2004 • 62 citations
Drug Adverse Reaction Target Database (DART)
2003 • 61 citations
SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical–protein interactome
2009 • 58 citations
NQO2 gene is associated with clozapine‐induced agranulocytosis
2003 • 55 citations
Clozapine-Induced Agranulocytosis and its Genetic Determinants
2008 • 55 citations
A Structure-Based Approach for Mapping Adverse Drug Reactions to the Perturbation of Underlying Biological Pathways
2010 • 52 citations
Data-Driven Methods to Discover Molecular Determinants of Serious Adverse Drug Events
2009 • 50 citations
Identifying Unexpected Therapeutic Targets via Chemical-Protein Interactome
2010 • 50 citations
SiMMap: a web server for inferring site-moiety map to recognize interaction preferences between protein pockets and compound moieties
2010 • 42 citations
DITOP: drug-induced toxicity related protein database
2007 • 35 citations
Computer Automated Prediction of Potential Therapeutic and Toxicity Protein Targets of Bioactive Compounds from Chinese Medicinal Plants
2002 • 30 citations
A CitationRank algorithm inheriting Google technology designed to highlight genes responsible for serious adverse drug reaction
2009 • 28 citations
Olanzapine treatment in patients with typical and atypical neuroleptic-associated agranulocytosis
1998 • 18 citations
[Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model].
2006 • 11 citations
Personalized Medicine: the Impact on Chemistry
2010 • 10 citations