Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators?

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

1990 • 3,462 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Transformations Related to the Angular and the Square Root

1950 • 2,378 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 • 1,626 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

Biologically active products of stimulated liver macrophages (Kupffer cells)

1990 • 926 citations

Hypolipidaemic hepatic peroxisome proliferators form a novel class of chemical carcinogens

1980 • 854 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Nitric Oxide Protects Cultured Rat Hepatocytes from Tumor Necrosis Factor-α-induced Apoptosis by Inducing Heat Shock Protein 70 Expression

1997 • 527 citations

Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy

1992 • 395 citations

Tumor necrosis factor receptor-mediated signaling pathways.

1994 • 389 citations

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

1984 • 369 citations

Transcriptional control of liver regeneration

1996 • 353 citations

Mechanistically-based Human Hazard Assessment of Peroxisome Proliferator-induced Hepatocarcinogenesis

1994 • 318 citations

The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

1993 • 308 citations

Hepatic peroxisome proliferation in rodents and its significance for humans

1993 • 271 citations

Cachectin (Tumor Necrosis Factor): A Macrophage Hormone Governing Cellular Metabolism and Inflammatory Response

1988 • 251 citations

Liver regeneration versus direct hyperplasia

1996 • 187 citations

Suppression of liver cell apoptosis in vitro by the non-genotoxic hepatocarcinogen and peroxisome proliferator nafenopin.

1994 • 186 citations

Excessivein vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis

1990 • 184 citations

Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): species differences and possible mechanisms.

1986 • 178 citations

Induction of early-immediate genes by tumor necrosis factor ? contribute to liver repair following chemical-induced hepatotoxicity

1997 • 152 citations

ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α

1997 • 136 citations

Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis

1996 • 101 citations

Peroxisome Induction Studies On Seven Phthalate Esters

1987 • 98 citations

Antibodies to tumor necrosis factor alpha prevent increases in cell replication in liver due to the potent peroxisome proliferator, WY- 14,643

1997 • 90 citations

Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes

1995 • 73 citations

Liver cell proliferation induced by nafenopin and cyproterone acetate is not associated with increases in activation of transcription factors NF-?B and AP-1 or with expression of tumor necrosis factor ?

1997 • 72 citations

Peroxisomes : biology and role in toxicology and disease

1996 • 70 citations

Treatment of rats with the peroxisome proliferator ciprofibrate results in increased liver NF-kB activity

1996 • 61 citations

Peroxisome proliferators activate Kupffer cells in vivo.

1996 • 56 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 55 citations

Peroxisome proliferation: current mechanisms relating to nongenotoxic carcinogenesis

1995 • 52 citations

Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver

1990 • 40 citations

Mechanism‐based Risk Assessment of Peroxisome Proliferating Rodent Hepatocarcinogens

1996 • 38 citations

Dexamethasone inhibits induction of liver tumor necrosis factor-alpha mRNA and liver growth induced by lead nitrate and ethylene dibromide.

1994 • 35 citations

Divide and rule

1996 • 23 citations