The molecular biology of heart failure

Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload.

1988 • 877 citations

Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.

1990 • 486 citations

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

1987 • 445 citations

Diastolic Dysfunction in Congestive Heart Failure

1991 • 349 citations

Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the rat.

1990 • 339 citations

Cardiac alpha- and beta-myosin heavy chain genes are organized in tandem.

1984 • 320 citations

Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.

1989 • 308 citations

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone.

1989 • 283 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy.

1992 • 223 citations

Expression of sarcoplasmic reticulum Ca(2+)-ATPase and calsequestrin genes in rat heart during ontogenic development and aging.

1991 • 194 citations

Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole.

1991 • 180 citations

Molecular cloning and characterization of a Ca2+ + Mg2+-dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum. Regulation of its expression by pressure overload and developmental stage.

1989 • 158 citations

Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

1989 • 154 citations

Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.

1992 • 154 citations

Structure, organization, and expression of the rat cardiac myosin light chain-2 gene

1989 • 140 citations

Myosin light chain-2 luciferase transgenic mice reveal distinct regulatory programs for cardiac and skeletal muscle-specific expression of a single contractile protein gene.

1992 • 137 citations

Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts.

1991 • 124 citations

Switches in cardiac muscle gene expression as a result of pressure and volume overload

1992 • 119 citations

Cardiac expressions of alpha- and beta-myosin heavy chains and sarcomeric alpha-actins are regulated through transcriptional mechanisms. Results from nuclear run-on assays in isolated rat cardiac nuclei.

1992 • 101 citations

Changes in Gene Expression during Cardiac Growth

1991 • 95 citations

Expression of the sarcomeric actin isogenes in the rat heart with development and senescence.

1992 • 82 citations

Gene expression in cardiac hypertrophy

1992 • 77 citations

Progressive changes from young adult age to senescence in mRNA for rat cardiac myosin heavy chain genes.

1991 • 55 citations

Gene transfer into cardiac myocytes in vivo

1991 • 30 citations

Regulation of myosin heavy chain and actin isogenes expression during cardiac growth

1991 • 19 citations

Description of an in vitro transcription assay in nuclei isolated from control and hemodynamically overloaded rat cardiac myocytes

1991 • 3 citations