Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs

1984 • 3,334 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

The Metabolic Basis of Inherited Disease.

1983 • 2,885 citations

Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis

1983 • 2,609 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Pyrimidine metabolism in microorganisms

1970 • 446 citations

Structure and function of the yeast URA3 gene: expression in Escherichia coli

1984 • 311 citations

Multifunctional Proteins

1976 • 221 citations

Water, Protein Folding, and the Genetic Code

1979 • 188 citations

Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement.

1985 • 160 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

1983 • 146 citations

A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases.

1983 • 137 citations

Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyl-transferase and comparison with other analogous enzymes

1986 • 136 citations

Comparative anatomy of the human APRT gene and enzyme: nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement.

1987 • 105 citations

Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.

1975 • 104 citations

Nucleotide sequence of the Escherichia coli pyrE gene and of the DNA in front of the protein-coding region

1983 • 87 citations

3-Ribosylpurines

1964 • 87 citations

Purification and Kinetic Properties of Brain Orotidine 5′-Phosphate Decarboxylase

1968 • 87 citations

Isolation and initial characterization of the single polypeptide that ssynthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase

1980 • 85 citations

Cloning of cDNA sequences of human adenosine deaminase.

1983 • 83 citations

Purification and Properties of Orotic Acid-decarboxylating Enzymes from Calf Thymus

1964 • 71 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype.

1967 • 69 citations

Coordinate overproduction of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in hamster cells resistant to pyrazofurin and 6-azauridine.

1979 • 65 citations

The isolation and characterization of the aspartate transcarbamylase domain of the multifunctional protein, CAD.

1983 • 59 citations

Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma.

1976 • 56 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains. II. Effects of 5-azaorotic acid, barbituric acid, and pyrimidine precursors on cellular phenotype.

1967 • 48 citations

Pyrimidine pathway variants of cultured mouse lymphoma cells with altered levels of both orotate phosphoribosyltransferase and orotidylate decarboxylase.

1979 • 46 citations

Isolation and characterization of the orotidine 5‘-monophosphate decarboxylase domain of the multifunctional protein uridine 5‘-monophosphate synthase.

1985 • 36 citations

Amplification of the UMP synthase gene and enzyme overproduction in pyrazofurin-resistant rat hepatoma cells. Molecular cloning of a cDNA for UMP synthase.

1984 • 34 citations

Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase.

1986 • 33 citations

The purification and preliminary characterization of UMP synthase from human placenta.

1987 • 31 citations

Crucial role of the connecting region joining the two functional domains of yeast tryptophan synthetase.

1987 • 27 citations

Isolation and characterization of 5-fluorouracil-resistant mutants of Chinese hamster ovary cells deficient in the activities of orotate phosphoribosyltransferase and orotidine 5?-monophosphate decarboxylase

1980 • 27 citations

Organization of a multifunctional protein in pyrimidine biosynthesis. A domain hypersensitive to proteolysis

1984 • 24 citations

Oxipurinol and orotic aciduria: Effect on the orotidine-5′-monophosphate decarboxylase activity of cultured human fibroblasts

1974 • 17 citations

Characterization of pyrazofurin-resistant HeLa cells with amplification of UMP synthase gene

1985 • 12 citations

Recognition and lysis of target cells by cytotoxic T lymphocytes.

1987 • 10 citations

Study of the kinetic and physical properties of the orotidine-5'-monophosphate decarboxylase domain from mouse UMP synthase produced in Saccharomyces cerevisiae.

1987 • 8 citations

[10] Orotate phosphoribosyltransferase (yeast)

1978 • 7 citations