Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Fluorouracil: biochemistry and pharmacology.

1988 • 825 citations

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

1981 • 287 citations

The Modulation of Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma

1990 • 287 citations

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

1982 • 254 citations

Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer

1989 • 220 citations

Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

1986 • 189 citations

Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase

1981 • 137 citations

Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.

1984 • 131 citations

Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

1988 • 96 citations

Enhancement of the antitumor effects of 5-fluorouracil by folinic acid

1990 • 92 citations

Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma.

1988 • 71 citations

Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.

1990 • 68 citations

The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts

1982 • 62 citations

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

1988 • 56 citations

Purine nucleosides as cell-specific modulators of 5-fluorouracil metabolism and cytotoxicity

1987 • 55 citations

Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.

1989 • 43 citations

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes

1989 • 39 citations

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: Enzyme activity and inhibition by 5-fluoro-2′-deoxyuridine-5′-monophosphate

1991 • 39 citations

Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma

1989 • 35 citations

Separation of 5-fluorouracil and uracil by ion-pair reversed-phase high-performance liquid chromatography on a column with porous polymeric packing

1984 • 33 citations

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities

1986 • 33 citations

In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma.

1988 • 32 citations

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.

1992 • 29 citations

Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma

1986 • 28 citations

Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin.

1992 • 24 citations

Distribution and Metabolism of Calcium Leucovorin in Normal and Tumor Tissue

1988 • 18 citations

Effect of intracellular folate concentration on the modulation of 5-fluorouracil cytotoxicity by the elevation of phosphoribosylpyrophosphate in cultured human KB cells.

1987 • 15 citations

Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil

1987 • 15 citations

Characterization of the parameters affecting covalent binding stoichiometry in binary and ternary complexes of thymidylate synthase

1990 • 12 citations

A method for the determination of total, free, and 5-fluorodeoxyuridylate-bound thymidylate synthase in cell extracts

1984 • 11 citations