The mechanisms of action of cyclosporin A in the treatment of psoriasis

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Cyclosporine

1989 • 1,340 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Characterization of intercellular adhesion molecule-1 and HLA-DR expression in normal inflamed skin: Modulation by recombinant gamma interferon and tumor necrosis factor

1989 • 505 citations

Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.

1991 • 437 citations

Cyclosporine for Plaque-Type Psoriasis

1991 • 427 citations

Epidermal cell (keratinocyte)-derived thymocyte-activating factor (ETAF).

1981 • 420 citations

Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1 alpha and beta mRNA. Keratinocyte epidermal cell-derived thymocyte-activating factor is identical to interleukin 1.

1986 • 384 citations

Cytokine Modulation of Keratinocyte Cytokines

1990 • 345 citations

Marked synergism between tumor necrosis factor-alpha and interferon-gamma in regulation of keratinocyte-derived adhesion molecules and chemotactic factors.

1990 • 261 citations

Detection of a gamma interferon-induced protein IP-10 in psoriatic plaques.

1988 • 231 citations

Retinoic Acid Receptor Gene Expression in Human Skin

1991 • 212 citations

Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation

1991 • 212 citations

Expression of Growth Hormone Receptor, Insulin-Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin

1992 • 205 citations

Expression of HLA-DR molecules by keratinocytes, and presence of Langerhans cells in the dermal infiltrate of active psoriatic plaques.

1986 • 196 citations

Psoriasis Induced at the Injection Site of Recombinant Interferon Gamma

1990 • 187 citations

Keratinocyte growth regulation by the products of immune cells.

1988 • 172 citations

Localization of Neutrophil-Activating Peptide-1/Interleukin-8-Immunoreactivity in Normal and Psoriatic Skin

1991 • 162 citations

The effects of cyclosporin A on T lymphocyte and dendritic cell sub-populations in psoriasis

1987 • 147 citations

IL-1 activity is reduced in psoriatic skin. Decreased IL-1 alpha and increased nonfunctional IL-1 beta.

1990 • 140 citations

Mast cells and macrophages in early relapsing psoriasis

1985 • 139 citations

Interleukin-1 receptor antagonist in normal and psoriatic epidermis.

1992 • 126 citations

Proliferating Cells in Psoriatic Dermis Are Comprised Primarily of T Cells, Endothelial Cells, and Factor XIIIa+ Perivascular Dendritic Cells

1991 • 120 citations

Levels of Cyclosporin in Epidermis of Treated Psoriasis Patients Differentially Inhibit Growth of Keratinocytes Cultured in Serum Free Versus Serum Containing Media

1988 • 116 citations

Interleukin 2 and Psoriasis

1988 • 113 citations

Psoriatic Epidermal Cells Demonstrate Increased Numbers and Function of Non-Langerhans Antigen-presenting Cells

1989 • 105 citations

Studies of the Effect of Cyclosporine in Psoriasis In Vivo: Combined Effects on Activated T Lymphocytes and Epidermal Regenerative Maturation

1992 • 105 citations

The Effect of Cyclosporin A on Epidermal Cells. II. Cyclosporin A Inhibits Proliferation of Normal and Transformed Keratinocytes

1988 • 100 citations

Intralesional cyclosporine in the treatment of psoriasis

1990 • 99 citations

UM4D4+ (CDw60) T Cells Are Compartmentalized into Psoriatic Skin and Release Lymphokines That Induce a Keratinocyte Phenotype Expressed in Psoriatic Lesions

1990 • 95 citations

The effect of cyclosporine on epidermal cells. I. Cyclosporine inhibits accessory cell functions of epidermal Langerhans cells in vitro.

1988 • 87 citations

Lymphokine gene expression in vivo is inhibited by cyclosporin A.

1990 • 85 citations

Cyclosporin A inhibits the production of gamma interferon (IFNγ), but does not inhibit production of virus-induced IFNα/β

1983 • 83 citations

Leukotriene B₄‐like material in scale of psoriatic skin lesions

1984 • 80 citations

Inhibition of Histamine and Prostaglandin D<sub>2</sub> Release from Human Lung Mast Cells by Ciclosporin A

1989 • 71 citations

Cyclosporin A Inhibits the Antigen-Presenting Functions of Freshly Isolated Human Langerhans Cells In Vitro

1991 • 69 citations

Cyclosporin A Suppresses ICAM-1 Expression by Papillary Endothelium in Healing Psoriatic Plaques

1991 • 68 citations

Cyclosporin A inhibits degranulation of rat basophilic leukemia cells and human basophils. Inhibition of mediator release without affecting PI hydrolysis or Ca2+ fluxes.

1990 • 62 citations

Epidermal Cell-Derived Thymocyte Activating Factor (ETAF) is a Potent T-Cell Chemoattractant

1985 • 60 citations

Additive and synergistic antiproliferative effects of cyclosporin A and gamma interferon on cultured human keratinocytes.

1988 • 60 citations

Mechanisms of Cyclosporine A Inhibition of Antigen-Presenting Activity in Uninvolved and Lesional Psoriatic Epidermis

1990 • 59 citations

Lymphocytes and macrophages of the epidermis and dermis in lesional psoriatic skin, but not epidermal Langerhans cells, are depleted by treatment with cyclosporin A

1989 • 57 citations

In situ localization of interferons in psoriatic lesions

1989 • 55 citations

T-Lymphocyte—Activating Properties of Epidermal Antigen-Presenting Cells from Normal and Psoriatic Skin: Evidence that Psoriatic Epidermal Antigen-Presenting Cells Resemble Cultured Normal Langerhans Cells

1991 • 52 citations

Adherence of Human Helper/Memory T-Cell Subsets To Psoriatic Dermal Endothelium

1990 • 50 citations

Cyclosporin a inhibits directly in vivo keratinocyte proliferation of living human skin

1989 • 48 citations

T-Cell Activation Is Potentiated by Cytokines Released by Lesional Psoriatic, but Not Normal, Epidermis

1992 • 48 citations

Immunohistochemical analysis of effects of cyclosporin A on gingival epithelium

1990 • 47 citations

Enhancement by various cytokines or 2-beta-mercaptoethanol of Ia antigen expression on Langerhans cells in skin from normal aged and young mice. Effect of cyclosporine A.

1989 • 46 citations

Cyclosporin A Does Not Inhibit Epidermal Cell Growth at Therapeutic Levels

1987 • 46 citations

The dependence of human T-lymphocyte migration on the 5-lipoxygenation of endogenous arachidonic acid

1981 • 45 citations

Mechanism of action of cyclosporine A in vivo. II. T cell priming in vivo to alloantigen can be mediated by an IL-2-independent cyclosporine A-resistant pathway.

1990 • 42 citations

Epidermis and Lymphocyte Interactions During a Tuberculin Skin Reaction. II. Epidermis Contains Specific Lymphocyte Chemotactic Factors

1986 • 35 citations

The Autologous Mixed Epidermal Cell–T Lymphocyte Reaction Is Elevated in Psoriasis: A Crucial Role for Epidermal HLA-DR+/CD1a- Antigen-Presenting Cells

1990 • 34 citations

Cyclosporin A inhibits IL 2-driven proliferation of human alloactivated T cells.

1986 • 33 citations

Factors Secreted by Untreated Psoriatic Monocytes Enhance Neutrophil Functions

1990 • 33 citations

Time-dependent inhibition of growth of human keratinocytes and fibroblasts by cyclosporin A: effect on keratinocytes at therapeutic blood levels

1990 • 31 citations

Cyclosporin A Inhibits Directly In Vivo Keratinocyte Proliferation of Living Human Skin.

1989 • 30 citations

Cyclosporine in Lamellar Ichthyosis

1989 • 28 citations

Influence of systemic cyclosporin A on interleukin-2 and epidermal growth factor receptor expression in psoriatic skin lesions.

1989 • 27 citations

Differential effects of cyclosporine A on Langerhans cells and regulatory T-cell populations in severe psoriasis: An immunohistochemical and flow cytometric analysis

1990 • 21 citations

Genomic, Phenotypic, and Functional Analyses of T Cells in Patients with Psoriasis Undergoing Systemic Cyclosporin A Treatment

1991 • 18 citations

Soluble IL-2 receptor and CD25 cells in psoriasis: effects of cyclosporin A and PUVA therapy

1991 • 16 citations

Induction of macrophage membrane interleukin 1 expression by T-cell dependent and T-cell independent pathways is inhibited by cyclosporin A

1989 • 16 citations

Presence of an inhibitor to androgen binding to receptor protein in human sebaceous gland and hair follicle

1988 • 14 citations

Deleted Work

1955 • 0 citations