Common allelic variants of cytochrome P4503A4 and their prevalence in different populations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

Characterization of single-nucleotide polymorphisms in coding regions of human genes

1999 • 1,531 citations

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis

1999 • 1,023 citations

Complex promoter and coding region β ₂ -adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

2000 • 971 citations

PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing

1997 • 946 citations

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1997 • 767 citations

Molecular Basis of Ethnic Differences in Drug Disposition and Response

2001 • 595 citations

Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome

1998 • 506 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

RESPONSE: Re: Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1999 • 478 citations

Evaluation of the genetic component of variability in CYP3A4 activity: a repeated drug administration method.

2000 • 399 citations

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

1994 • 390 citations

Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

1998 • 348 citations

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity

2000 • 346 citations

Association of CYP 3 A 4 genotype with treatment-related leukemia

1998 • 315 citations

Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory Region

1999 • 302 citations

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

2001 • 285 citations

CYP3A activity in African American and European American men: Population differences and functional effect of the CYP3A4*1B 5′-promoter region polymorphism

2000 • 250 citations

The role of individual human cytochrpmes P450 in drug metabolism and clinical response

1992 • 246 citations

Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4

1999 • 237 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Identification and functional characterization of eight CYP3A4 protein variants.

2001 • 223 citations

Novel mutations of CYP3A4 in Chinese.

2001 • 184 citations

The human drug metabolizing cytochromes P450

1996 • 166 citations

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.

1987 • 160 citations

Molecular modeling of cytochrome P450 3A4.

1997 • 129 citations

16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5

1998 • 70 citations

Ethnic differences in the pharmacokinetics of oral nifedipine.

1991 • 60 citations

The CYP3A4*3 Allele: Is It Really Rare?

2001 • 56 citations

Genetic Testing-- Present and Future

2000 • 50 citations

Pharmacokinetics of Nifedipine Slow Release Tablet in Mexican Subjects: Further Evidence for an Oxidation Polymorphism

1989 • 37 citations

Pharmacokinetics of Oral Nifedipine in Different Populations

1993 • 37 citations

cyclosporine and liver transplantation: Will the midazolam test make blood level monitoring obsolete?

1995 • 24 citations

Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds

1992 • 15 citations