M-CAT, CArG, and Sp1 Elements Are Required for α1-Adrenergic Induction of the Skeletal α-Actin Promoter during Cardiac Myocyte Hypertrophy

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Luciferase reporter gene vectors for analysis of promoters and enhancers.

1988 • 1,016 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro

1985 • 805 citations

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

1983 • 618 citations

The serum response element

1992 • 458 citations

Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.

1987 • 445 citations

Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1

1991 • 421 citations

Control of Cardiac Gene Expression by Mechanical Stress

1993 • 343 citations

Localization of Protein Kinase C Isozymes in Cardiac Myocytes

1994 • 342 citations

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.

1994 • 325 citations

Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.

1986 • 282 citations

A protein kinase C isozyme is translocated to cytoskeletal elements on activation.

1990 • 257 citations

Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene.

1988 • 248 citations

Growth Factors Proto-Oncogenes and Plasticity of the Cardiac Phenotype

1991 • 228 citations

Induction of the skeletal alpha-actin gene in alpha 1-adrenoceptor-mediated hypertrophy of rat cardiac myocytes.

1987 • 201 citations

The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes.

1990 • 200 citations

M-CAT Binding Factor, a Novel trans-Acting Factor Governing Muscle-Specific Transcription

1990 • 193 citations

Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to α1-adrenergic and phorbol ester stimulation

1988 • 185 citations

A conserved CATTCCT motif is required for skeletal muscle-specific activity of the cardiac troponin T gene promoter.

1988 • 183 citations

A MyoD1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells.

1991 • 175 citations

M-CAT binding factor is related to the SV40 enhancer binding factor, TEF-1.

1992 • 172 citations

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1

1994 • 167 citations

The sarcomeric actin CArG-binding factor is indistinguishable from the c-fos serum response factor.

1989 • 166 citations

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene

1991 • 161 citations

Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.

1989 • 154 citations

Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium.

1992 • 154 citations

A growth factor for cardiac myocytes is produced by cardiac nonmyocytes.

1991 • 151 citations

An enhancer core element mediates stimulation of the rat beta-myosin heavy chain promoter by an alpha 1-adrenergic agonist and activated beta-protein kinase C in hypertrophy of cardiac myocytes.

1994 • 146 citations

Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells.

1989 • 138 citations

A combination of closely associated positive and negative cis-acting promoter elements regulates transcription of the skeletal alpha-actin gene.

1990 • 124 citations

Identification and Characterization of a Cardiac-Specific Transcriptional Regulatory Element in the Slow/Cardiac Troponin C Gene

1992 • 122 citations

In vivo analysis of the murine beta-myosin heavy chain gene promoter.

1993 • 120 citations

Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription.

1994 • 114 citations

Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy.

1991 • 110 citations

Analysis of the upstream regions governing expression of the chicken cardiac troponin T gene in embryonic cardiac and skeletal muscle cells.

1988 • 109 citations

Characterization of a promoter element required for transcription in myocardial cells.

1991 • 109 citations

Transcriptional enhancer factor-1 in cardiac myocytes interacts with an alpha 1-adrenergic- and beta-protein kinase C-inducible element in the rat beta-myosin heavy chain promoter.

1993 • 103 citations

Cardiac expressions of alpha- and beta-myosin heavy chains and sarcomeric alpha-actins are regulated through transcriptional mechanisms. Results from nuclear run-on assays in isolated rat cardiac nuclei.

1992 • 101 citations

Myocardial activation of the human cardiac alpha-actin promoter by helix-loop-helix proteins.

1992 • 96 citations

The Complete Sequence of the Mouse Skeletal α-Actin Gene Reveals Several Conserved and Inverted Repeat Sequences Outside of the Protein-Coding Region

1986 • 96 citations

Transcription of early developmental isogenes in cardiac myocyte hypertrophy

1989 • 94 citations

M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription.

1990 • 88 citations

Characterization of a strong positive cis-acting element of the human beta-myosin heavy chain gene in fetal rat heart cells.

1992 • 87 citations

Expression of the sarcomeric actin isogenes in the rat heart with development and senescence.

1992 • 82 citations

Gene injection into canine myocardium as a useful model for studying gene expression in the heart of large mammals.

1993 • 80 citations

Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain β gene

1993 • 73 citations

A nuclear pathway for alpha 1-adrenergic receptor signaling in cardiac cells.

1993 • 70 citations

The chicken fast skeletal troponin I gene: exon organization and sequence

1986 • 69 citations

Identification and characterization of a cardiac-specific transcriptional regulatory element in the slow/cardiac troponin C gene.

1992 • 67 citations

Positive and negative control of the skeletal alpha-actin promoter in cardiac muscle. A proximal serum response element is sufficient for induction by basic fibroblast growth factor (FGF) but not for inhibition by acidic FGF.

1992 • 60 citations

An M-CAT Binding Factor and an RSRF-Related A-Rich Binding Factor Positively Regulate Expression of the α-Cardiac Myosin Heavy-Chain Gene In Vivo

1994 • 59 citations

The molecular biology of heart failure

1993 • 58 citations

The complete sequence of the mouse skeletal alpha-actin gene reveals several conserved and inverted repeat sequences outside of the protein-coding region.

1986 • 45 citations

Natural and synthetic DNA elements with the CArG motif differ in expression and protein-binding properties.

1991 • 41 citations

Mapping of the pressure response element of the c-fos gene by direct DNA injection into beating hearts.

1993 • 38 citations

An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo.

1994 • 30 citations

Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice.

1994 • 22 citations

Tissue specific expression of an α-skeletal actin-lacZ fusion gene during development in transgenic mice

1994 • 13 citations

Muscle-Specific Transcriptional Activation by CArG Box Requires Either Homophilic or Heterophilic Interactions of the CArG Box Binding Factors

1993 • 3 citations