Water Structural Changes at the Proton Uptake Site (the Thr46-Asp96 Domain) in the L Intermediate of Bacteriorhodopsin

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

[69] Isolation of the cell membrane of Halobacterium halobium and its fractionation into red and purple membrane

1974 • 1,690 citations

From Femtoseconds to Biology: Mechanism of Bacteriorhodopsin's Light-Driven Proton Pump

1991 • 532 citations

Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212

1988 • 497 citations

Proton translocation mechanism and energetics in the light-driven pump bacteriorhodopsin

1993 • 350 citations

Role of aspartate-96 in proton translocation by bacteriorhodopsin.

1989 • 348 citations

Analysis of amino acids as their tert.-butyldimethylsilyl derivatives by gas—liquid chromatography and mass spectrometry

1986 • 236 citations

Kinetic and spectroscopic evidence for an irreversible step between deprotonation and reprotonation of the Schiff base in the bacteriorhodopsin photocycle

1991 • 221 citations

Water is required for proton transfer from aspartate-96 to the bacteriorhodopsin Schiff base

1991 • 197 citations

Properties of Asp212—-Asn bacteriorhodopsin suggest that Asp212 and Asp85 both participate in a counterion and proton acceptor complex near the Schiff base

1991 • 174 citations

Fourier transform infrared study of the N intermediate of bacteriorhodopsin

1991 • 129 citations

Bacteriorhodopsin mutants containing single substitutions of serine or threonine residues are all active in proton translocation.

1991 • 113 citations

The Association of Water with Bases and Anions in an Inert Solvent¹

1965 • 112 citations

Growth and nutrition of extremely halophilic bacteria

1969 • 101 citations

Water structural changes in the bacteriorhodopsin photocycle: analysis by Fourier transform infrared spectroscopy

1992 • 99 citations

Molecular Dynamics Study of Bacteriorhodopsin and Artificial Pigments

1994 • 94 citations

Detection of a water molecule in the active-site of bacteriorhodopsin: hydrogen bonding changes during the primary photoreaction

1994 • 86 citations

Interaction of Aspartate-85 with a Water Molecule and the Protonated Schiff Base in the L Intermediate of Bacteriorhodopsin: A Fourier-Transform Infrared Spectroscopic Study

1994 • 86 citations

Protein changes associated with reprotonation of the Schiff base in the photocycle of Asp96–>Asn bacteriorhodopsin. The MN intermediate with unprotonated Schiff base but N-like protein structure.

1992 • 82 citations

Structures of aspartic acid-96 in the L and N intermediates of bacteriorhodopsin: analysis by Fourier transform infrared spectroscopy

1992 • 80 citations

Complete Identification of C:O Stretching Vibrational Bands of Protonated Aspartic Acid Residues in the Difference Infrared Spectra of M and N Intermediates versus Bacteriorhodopsin

1994 • 78 citations

Water-Mediated Proton Transfer in Proteins: An FTIR Study of Bacteriorhodopsin

1995 • 75 citations

The Proton Transfers in the Cytoplasmic Domain of Bacteriorhodopsin are Facilitated by a Cluster of Interacting Residues

1994 • 70 citations

Relationship of proton release at the extracellular surface to deprotonation of the schiff base in the bacteriorhodopsin photocycle

1995 • 61 citations

FOURIER TRANSFORM INFRARED SPECTRAL STUDIES ON THE SCHIFF BASE MODE OF ALL‐trans BACTERIORHODOPSIN and ITS PHOTOINTERMEDIATES, K and L*

1991 • 60 citations

Vibrational spectroscopy of bacteriorhodopsin mutants. Evidence that Thr-46 and Thr-89 form part of a transient network of hydrogen bonds.

1992 • 60 citations

Interaction of tryptophan-182 with the retinal 9-methyl group in the L intermediate of bacteriorhodopsin

1995 • 58 citations

Asp96 deprotonation and transmembrane alpha-helical structural changes in bacteriorhodopsin.

1993 • 54 citations

Asymmetric Synthesis via Heterocyclic Intermediates; XXIV¹. Asymmetric Synthesis of Enantiomerically and Diastereomerically Pure D-Threonine by the Bis-lactim Ether Method

1985 • 46 citations

Photoreaction of the N intermediate of bacteriorhodopsin, and its relationship to the decay kinetics of the M intermediate

1993 • 32 citations

Spectroscopic study of the batho-to-lumi transition during the photobleaching of rhodopsin using ring-modified retinal analogs

1991 • 31 citations