From Femtoseconds to Biology: Mechanism of Bacteriorhodopsin's Light-Driven Proton Pump

Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy

1990 • 2,969 citations

Time-dependent quantum-mechanical methods for molecular dynamics

1988 • 1,749 citations

Direct Observation of the Femtosecond Excited-State cis - trans Isomerization in Bacteriorhodopsin

1988 • 546 citations

Vibrational spectroscopy of bacteriorhodopsin mutants: light-driven proton transport involves protonation changes of aspartic acid residues 85, 96, and 212

1988 • 497 citations

Nature of the primary photochemical events in rhodopsin and bacteriorhodopsin

1990 • 446 citations

Aspartic acid-96 is the internal proton donor in the reprotonation of the Schiff base of bacteriorhodopsin.

1989 • 318 citations

Bacteriorhodopsin, a membrane protein that uses light to translocate protons.

1988 • 293 citations

Aspartic acid substitutions affect proton translocation by bacteriorhodopsin.

1988 • 282 citations

Wave packet theory of dynamic absorption spectra in femtosecond pump–probe experiments

1990 • 276 citations

Chromophore structure in bacteriorhodopsin's N intermediate: implications for the proton-pumping mechanism

1988 • 242 citations

Substitution of amino acids Asp-85, Asp-212, and Arg-82 in bacteriorhodopsin affects the proton release phase of the pump and the pK of the Schiff base.

1990 • 234 citations

Bacteriorhodopsin photoreaction: identification of a long-lived intermediate N (P, R350) at high pH and its M-like photoproduct

1988 • 154 citations

The role of back-reactions and proton uptake during the N .fwdarw. O transition in bacteriorhodopsin's photocycle: a kinetic resonance Raman study

1990 • 153 citations

On the protein (tyrosine)-chromophore (protonated Schiff base) coupling in bacteriorhodopsin.

1984 • 138 citations

Millisecond Fourier-transform infrared difference spectra of bacteriorhodopsin's M412 photoproduct.

1987 • 123 citations

Structure-Function Studies on Bacteriorhodopsin

1989 • 109 citations

Quantum-mechanical theory for 6 fs dynamic absorption spectroscopy and its application to nile blue

1990 • 109 citations

Direct observation of the excited-state c i s–t r a n s photoisomerization of bacteriorhodopsin: Multilevel line shape theory for femtosecond dynamic hole burning and its application

1989 • 101 citations

Orientation of the protonated retinal Schiff base group in bacteriorhodopsin from absorption linear dichroism

1989 • 89 citations

Structure and function of rhodopsins from solid state NMR and resonance Raman spectroscopy of isotopic retinal derivatives

1988 • 82 citations

Substitution of membrane-embedded aspartic acids in bacteriorhodopsin causes specific changes in different steps of the photochemical cycle

1989 • 76 citations

Independent photocycles of the spectrally distinct forms of bacteriorhodopsin

1988 • 72 citations

Kinetic resonance Raman studies reveal different conformational states of bacteriorhodopsin

1988 • 64 citations