Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

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Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

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β-Arrestins and Cell Signaling

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β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

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Hallucinogens

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Role of Caveolae and Caveolins in Health and Disease

2004 • 882 citations

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

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DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS

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Lipid raft microdomains and neurotransmitter signalling

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Signal-Processing Machines at the Postsynaptic Density

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Hallucinogens Recruit Specific Cortical 5-HT2A Receptor-Mediated Signaling Pathways to Affect Behavior

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Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

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Binding of Neuroligins to PSD-95

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β-Arrestin-biased ligands at seven-transmembrane receptors

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MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

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5-Hydroxytryptamine _2A serotonin receptors in the primate cerebral cortex: Possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites

1998 • 510 citations

Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals

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5-HT_2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex

1997 • 448 citations

Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules

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A diffusion barrier maintains distribution of membrane proteins in polarized neurons

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Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome

1996 • 398 citations

Segregation of Heterotrimeric G Proteins in Cell Surface Microdomains

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G-protein-coupled receptors at a glance

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Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex

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Autoregulatory Mechanisms in Protein-tyrosine Kinases

1998 • 319 citations

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

2001 • 281 citations

5-Hydroxytryptamine2-Family Receptors (5-Hydroxytryptamine2A, 5-Hydroxytryptamine2B, 5-Hydroxytryptamine2C) Where Structure Meets Function

1998 • 280 citations

From Src Homology domains to other signaling modules: proposal of the `protein recognition code'

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Molecular Targets for Treating Cognitive Dysfunction in Schizophrenia

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Multiple Serotonin Receptors: Clinical and Experimental Aspects

1994 • 212 citations

Ultrastructural localization of serotonin2A receptors in the middle layers of the rat prelimbic prefrontal cortex

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Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo

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Structure‐function relationships in Src family and related protein tyrosine kinases

1995 • 201 citations

Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus

1999 • 186 citations

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Cholesterol Depletion Disrupts Caveolae and Differentially Impairs Agonist-Induced Arterial Contraction

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Serotonin Inhibits Voltage-Gated K ⁺ Currents in Pulmonary Artery Smooth Muscle Cells

2006 • 171 citations

Synaptic multiprotein complexes associated with 5-HT2C receptors: a proteomic approach

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Caveolin-1 Interacts with 5-HT2A Serotonin Receptors and Profoundly Modulates the Signaling of Selected Gαq-coupled Protein Receptors

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The Serotonin 5-HT2A and 5-HT2C Receptors Interact with Specific Sets of PDZ Proteins

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Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo

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β1-Adrenergic Receptor Association with PSD-95

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A Direct Interaction of PSD-95 with 5-HT2A Serotonin Receptors Regulates Receptor Trafficking and Signal Transduction

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The Dynamin-dependent, Arrestin-independent Internalization of 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptors Reveals Differential Sorting of Arrestins and 5-HT2A Receptors during Endocytosis

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Salvinorin A: the ‘magic mint’ hallucinogen finds a molecular target in the kappa opioid receptor

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5-Hydroxytryptamine2 receptors coupled to phospholipase C in rat aorta: modulation of phosphoinositide turnover by phorbol ester.

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Do classical hallucinogens act as 5-HT2 agonists or antagonists?

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The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis

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A New Dominant Gene Mental Retardation Syndrome

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Serotonin 5-HT2A Receptors: Molecular Biology and Mechanisms of Regulation

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Structure and Function of the Third Intracellular Loop of the 5‐Hydroxytryptamine_2A Receptor: The Third Intracellular Loop Is α‐Helical and Binds Purified Arrestins

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Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro.

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Similar ultrastructural distribution of the 5-HT2A serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat

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Cell-Type Specific Effects of Endocytosis Inhibitors on 5-Hydroxytryptamine_2AReceptor Desensitization and Resensitization Reveal an Arrestin-, GRK2-, and GRK5-Independent Mode of Regulation in Human Embryonic Kidney 293 Cells

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The serotonin receptors : from molecular pharmacology to human therapeutics

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Signaling proteins in raft-like microdomains are essential for Ca2+ wave propagation in glial cells

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Molecular Mechanism of the Inhibition of Phospholipase C β3 by Protein Kinase C

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Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gsα Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase

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Deletion of the Coffin–Lowry Syndrome Gene Rsk2 in Mice is Associated With Impaired Spatial Learning and Reduced Control of Exploratory Behavior

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The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro

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Regulation of D1 Dopamine Receptor Trafficking and Signaling by Caveolin-1

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Serotonin-induced acute desensitization of serotonin2 receptors in human platelets via a mechanism involving protein kinase C.

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Interaction of Calmodulin with the Serotonin 5-Hydroxytryptamine2A Receptor

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Selectivity and promiscuity in the interaction network mediated by protein recognition modules

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Pleiotropic Behavior of 5‐HT_2A and 5‐HT_2C Receptor Agonists

1998 • 67 citations

Severe deficits in 5‐HT_2A‐mediated neurotransmission in BDNF conditional mutant mice

2006 • 62 citations

Mechanisms of Ligand-Induced Desensitization of the 5-Hydroxytryptamine_2AReceptor

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The Interaction of a Constitutively Active Arrestin with the Arrestin-Insensitive 5-HT_2AReceptor Induces Agonist-Independent Internalization

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Deletion of the Serotonin 5-HT2C Receptor PDZ Recognition Motif Prevents Receptor Phosphorylation and Delays Resensitization of Receptor Responses

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Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization

1995 • 58 citations

DLGS97/SAP97 Is Developmentally Upregulated and Is Required for Complex Adult Behaviors and Synapse Morphology and Function

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New role of IKKα/β phosphorylated IκBα in axon outgrowth and axon initial segment development

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p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling

2006 • 49 citations

Identification of Two Serine Residues Essential for Agonist-Induced 5-HT_2A Receptor Desensitization

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Ribosomal S6 Kinase 2 Directly Phosphorylates the 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptor, Thereby Modulating 5-HT2A Signaling

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Insights into the structure and function of 5-HT₂familyserotonin receptors reveal novel strategies for therapeutic target development

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The movement disorders of Coffin–Lowry syndrome

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Activation is Hallucinogenic and Antagonism is Therapeutic: Role of 5-HT2A Receptors in Atypical Antipsychotic Drug Actions

1999 • 27 citations

Molecular and Cellular Mechanisms for the Polarized Sorting of Serotonin Receptors: Relevance for Genesis and Treatment of Psychosis

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Agonist Induced-Phosphorylation of G_α11Protein Reduces Coupling to 5-HT_2AReceptors

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The association between Coffin‐Lowry syndrome and psychosis: a family study

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Loss of cortical serotonin2A signal transduction in senescent rats: Reversal following inhibition of protein kinase C

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Regulation of 5-HT2A/C receptors and DOI-induced behaviors by protein kinase Cγ

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Electrophysiological studies on the actions of hallucinogenic drugs at 5-HT2 receptors in rat brain.

1994 • 8 citations

Electrophysiological Studies on the Actions of Hallucinogenic Drugs at 5=HT2 Receptors in Rat Brain

1994 • 8 citations