The Interaction of a Constitutively Active Arrestin with the Arrestin-Insensitive 5-HT_2AReceptor Induces Agonist-Independent Internalization

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

2002 • 740 citations

Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat

1999 • 498 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex

1997 • 324 citations

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

2001 • 281 citations

Targeted Construction of Phosphorylation-independent β-Arrestin Mutants with Constitutive Activity in Cells

1999 • 200 citations

How Does Arrestin Respond to the Phosphorylated State of Rhodopsin?

1999 • 185 citations

Phosphorylation and Desensitization of Human Endothelin A and B Receptors

1997 • 185 citations

Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity

1997 • 182 citations

Evidence for a Model of Agonist-induced Activation of 5-Hydroxytryptamine 2A Serotonin Receptors That Involves the Disruption of a Strong Ionic Interaction between Helices 3 and 6

2002 • 177 citations

Internalization of the m2 Muscarinic Acetylcholine Receptor

1997 • 170 citations

The Dynamin-dependent, Arrestin-independent Internalization of 5-Hydroxytryptamine 2A (5-HT2A) Serotonin Receptors Reveals Differential Sorting of Arrestins and 5-HT2A Receptors during Endocytosis

2001 • 158 citations

Visual Arrestin Binding to Rhodopsin

1995 • 157 citations

Mechanism of Phosphorylation-Recognition by Visual Arrestin and the Transition of Arrestin into a High Affinity Binding State

1997 • 131 citations

Properties of Secretin Receptor Internalization Differ from Those of the β2-Adrenergic Receptor

1999 • 109 citations

Structure and Function of the Third Intracellular Loop of the 5‐Hydroxytryptamine_2A Receptor: The Third Intracellular Loop Is α‐Helical and Binds Purified Arrestins

1999 • 106 citations

Arrestin-independent Internalization of the m1, m3, and m4 Subtypes of Muscarinic Cholinergic Receptors

1998 • 105 citations

Rapid agonist-induced internalization of the 5-hydroxytryptamine2A receptor occurs via the endosome pathway in vitro.

1996 • 102 citations

Cell-Type Specific Effects of Endocytosis Inhibitors on 5-Hydroxytryptamine_2AReceptor Desensitization and Resensitization Reveal an Arrestin-, GRK2-, and GRK5-Independent Mode of Regulation in Human Embryonic Kidney 293 Cells

2001 • 98 citations

The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a β-Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers β-Arrestin Dependency

2000 • 90 citations

Arrestin with a Single Amino Acid Substitution Quenches Light-Activated Rhodopsin in a Phosphorylation-Independent Fashion

1997 • 81 citations

Evidence for distinct subcellular sites of opiate receptors. Demonstration of opiate receptors in smooth microsomal fractions isolated from rat brain.

1981 • 78 citations

The Association of Arrestin-3 with the Human Lutropin/Choriogonadotropin Receptor Depends Mostly on Receptor Activation Rather than on Receptor Phosphorylation

2002 • 68 citations

Casein Kinase II Sites in the Intracellular C-terminal Domain of the Thyrotropin-releasing Hormone Receptor and Chimeric Gonadotropin-releasing Hormone Receptors Contribute to β-Arrestin-dependent Internalization

2001 • 67 citations

Internalization of the HumanN-Formyl Peptide and C5a Chemoattractant Receptors Occurs via Clathrin-Independent Mechanisms

2001 • 59 citations

Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells

2001 • 58 citations

Distinct Mechanisms Regulate 5-HT2 and Thrombin Receptor Desensitization

1995 • 58 citations

μ-Opioid Receptors Desensitize Less Rapidly than δ-Opioid Receptors Due to Less Efficient Activation of Arrestin

2002 • 55 citations

Identification of receptor domains that modify ligand binding to 5-hydroxytryptamine2 and 5-hydroxytryptamine1c serotonin receptors.

1992 • 47 citations

Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain

1986 • 47 citations

Stereospecific opiate-binding sites occur in coated vesicles

1985 • 35 citations

The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a -Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers -Arrestin Dependency

2000 • 24 citations