Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/GTP exchange protein for small GTP-binding proteins.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

ras GENES

1987 • 3,818 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 • 597 citations

Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain

1988 • 533 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

1990 • 264 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.

1990 • 154 citations

Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.

1987 • 128 citations

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells

1986 • 118 citations

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

1991 • 110 citations

Phosphorylation of smg p21, a ras p21-like GTP-binding Protein, by Cyclic AMP-dependent Protein Kinase in a Cell-free System and in Response to Prostaglandin E1 in Intact Human Platelets

1989 • 110 citations

Enhancement of the actions of smg p21 GDP/GTP exchange protein by the protein kinase A-catalyzed phosphorylation of smg p21.

1991 • 102 citations

Phosphorylation by cyclic AMP-dependent protein kinase of a human platelet Mr 22,000 GTP-binding protein (smg p21) having the same putative effector domain as the ras gene products

1988 • 88 citations

Ras interaction with the GTPase‐activating protein (GAP)

1989 • 87 citations

Activation of the Serum Response Element and 12-O-Tetradecanoylphorbol-13-Acetate Response Element by the Activated c-raf-1 Protein in a Manner Independent of Protein Kinase C

1989 • 71 citations

Preparation of anti-ras Mr 21,000 protein monoclonal antibodies and immunohistochemical analyses on expression of ras genes in human stomach and thyroid cancers.

1988 • 58 citations

Activation of the c-fos serum-response element by the activated c-Ha-ras protein in a manner independent of protein kinase C and cAMP-dependent protein kinase.

1990 • 57 citations

Analysis of guanine nucleotide bound to ras protein in PC12 cells

1988 • 41 citations

The smg GDS-induced activation of smg p21 is initiated by cyclic AMP-dependent protein kinase-catalyzed phosphorylation of smg p21

1991 • 27 citations

The COOH-domain of the product of the Saccharomyces cerevisiae SCD25 gene elicits activation of p21-ras proteins in mammalian cells.

1991 • 16 citations

Comparison of the mode of action ofrasp21 with those of protein kinases A and C in the stimulation of gene expression in NIH/3T3 cells

1990 • 3 citations