Functional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders

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The Organization of Behavior; A Neuropsychological Theory

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The Organization of Behavior: A Neuropsychological Theory

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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

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Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

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Neuregulin 1 and Susceptibility to Schizophrenia

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The principal features and mechanisms of dopamine modulation in the prefrontal cortex

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The Neuropsychopharmacology of Phencyclidine From NMDA Receptor Hypofunction to the Dopamine Hypothesis of Schizophrenia

1999 • 1,300 citations

Increased prefrontal and parietal activity after training of working memory

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NMDA Receptor Hypofunction Produces Opposite Effects on Prefrontal Cortex Interneurons and Pyramidal Neurons

2007 • 1,175 citations

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Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms

1995 • 1,082 citations

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

2007 • 1,021 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris‐leucoagglutinin

1991 • 827 citations

Supranormal Stimulation of D₁Dopamine Receptors in the Rodent Prefrontal Cortex Impairs Spatial Working Memory Performance

1997 • 805 citations

Beyond the Dopamine Receptor

1999 • 742 citations

The Prefrontal Cortex as a Key Target of the Maladaptive Response to Stress

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Dopamine: a potential substrate for synaptic plasticity and memory mechanisms

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Changes in Cortical Dopamine D1 Receptor Binding Associated with Cognitive Training

2009 • 540 citations

Dopaminergic Terminals in the Rat Cortex

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Catecholamine regulation of the prefrontal cortex

1997 • 478 citations

Chronic Stress Induces Impairment of Spatial Working Memory Because of Prefrontal Dopaminergic Dysfunction

2000 • 471 citations

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

2004 • 453 citations

Multiple subpial transection: a new approach to the surgical treatment of focal epilepsy

1989 • 447 citations

Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition

2003 • 410 citations

Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia

2004 • 384 citations

D1/D5 Dopamine Receptor Activation Increases the Magnitude of Early Long-Term Potentiation at CA1 Hippocampal Synapses

1996 • 374 citations

Essential Role of D1 But Not D2 Receptors in the NMDA Receptor-Dependent Long-Term Potentiation at Hippocampal-Prefrontal Cortex SynapsesIn Vivo

2000 • 369 citations

The Prefrontal Cortex Regulates Lateral Amygdala Neuronal Plasticity and Responses to Previously Conditioned Stimuli

2003 • 350 citations

The Neuregulin-1 Receptor ErbB4 Controls Glutamatergic Synapse Maturation and Plasticity

2007 • 340 citations

Under the curve: Critical issues for elucidating D1 receptor function in working memory

2005 • 328 citations

Dopaminergic modulation of long‐lasting direct current‐induced cortical excitability changes in the human motor cortex

2006 • 318 citations

Acute Stress-induced Changes in Hippocampal/Prefrontal Circuits in Rats: Effects of Antidepressants

2003 • 303 citations

Exposure to Acute Stress Blocks the Induction of Long-Term Potentiation of the Amygdala–Prefrontal Cortex PathwayIn Vivo

2003 • 294 citations

Dopamine Receptor Stimulation Modulates AMPA Receptor Synaptic Insertion in Prefrontal Cortex Neurons

2005 • 292 citations

Chemistry of the mind: Neurochemical modulation of prefrontal cortical function

2005 • 289 citations

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia

2004 • 244 citations

Distributed Network Actions by Nicotine Increase the Threshold for Spike-Timing-Dependent Plasticity in Prefrontal Cortex

2007 • 243 citations

The Formation of Abnormal Associations in Schizophrenia: Neural and Behavioral Evidence

2007 • 222 citations

A Theory of Dopamine Function and Its Role in Cognitive Deficits in Schizophrenia

1993 • 206 citations

Dopamine facilitates long-term depression of glutamatergic transmission in rat prefrontal cortex

1998 • 201 citations

Coactivation of D1 and D2 dopamine receptors is required for long-term synaptic depression in the striatum

1992 • 198 citations

Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

2009 • 197 citations

Evidence for Impaired Long-Term Potentiation in Schizophrenia and Its Relationship to Motor Skill Leaning

2007 • 191 citations

Dopaminergic Modulation of Long-term Synaptic Plasticity in Rat Prefrontal Neurons

2003 • 190 citations

Integrity of the mesocortical dopaminergic system is necessary for complete expression of in vivo hippocampal–prefrontal cortex long-term potentiation

1999 • 190 citations

Dopamine Receptors and Groups I and II mGluRs Cooperate for Long-Term Depression Induction in Rat Prefrontal Cortex through Converging Postsynaptic Activation of MAP Kinases

1999 • 185 citations

Targeting metabotropic glutamate receptors for treatment of the cognitive symptoms of schizophrenia

2004 • 185 citations

Cognitive Remediation and Vocational Rehabilitation for Schizophrenia

2005 • 184 citations

Stress‐Induced Sensitization of Dopamine and Norepinephrine Efflux in Medial Prefrontal Cortex of the Rat

1994 • 178 citations

Synaptic Plasticity in an In Vitro Slice Preparation of the Rat Nucleus Accumbens

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Behavioral Evidence for Interactions between a Hallucinogenic Drug and Group II Metabotropic Glutamate Receptors

2000 • 162 citations

From arousal to cognition: the integrative position of the prefrontal cortex

2000 • 144 citations

Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors

2008 • 137 citations

D₂ dopamine receptors recruit a GABA component for their attenuation of excitatory synaptic transmission in the adult rat prefrontal cortex

2007 • 132 citations

Post-Pubertal Disruption of Medial Prefrontal Cortical Dopamine–Glutamate Interactions in a Developmental Animal Model of Schizophrenia

2007 • 131 citations

Dysfunctional Neural Plasticity in Patients With Schizophrenia

2008 • 127 citations

TMT, a predator odor, elevates mesoprefrontal dopamine metabolic activity and disrupts short-term working memory in the rat

2000 • 124 citations

The Presence of Background Dopamine Signal Converts Long-Term Synaptic Depression to Potentiation in Rat Prefrontal Cortex

2006 • 120 citations

The "delayed onset" of antipsychotic action--an idea whose time has come and gone.

2006 • 106 citations

Plasticity in the Mediodorsal Thalamo-Prefrontal Cortical Transmission in Behaving Mice

1999 • 103 citations

Postsynaptic calcium is necessary for the induction of LTP and LTD of monosynaptic EPSPs in prefrontal neurons: An in vitro study in the rat

1992 • 102 citations

Long-Term Depression Induced by Postsynaptic Group II Metabotropic Glutamate Receptors Linked to Phospholipase C and Intracellular Calcium Rises in Rat Prefrontal Cortex

2002 • 102 citations

Target‐Specific Glutamatergic Regulation of Dopamine Neurons in the Ventral Tegmental Area

2000 • 101 citations

D₁-Receptor Impact on Neuroplasticity in Humans

2009 • 101 citations

Chronic Haloperidol Promotes Corticostriatal Long-Term Potentiation by Targeting Dopamine D2L Receptors

2004 • 100 citations

Induction of stable long‐term depression in vivo in the hippocampal–prefrontal cortex pathway

1999 • 98 citations

Alterations in Medial Prefrontal Cortical Activity and Plasticity in Rats with Disruption of Cortical Development

2006 • 92 citations

Dopamine favours the emergence of long-term depression versus long-term potentiation in slices of rat prefrontal cortex

1995 • 88 citations

A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia

2007 • 86 citations

Durability of cognitive remediation training in schizophrenia: performance on two memory tasks at 6-month and 12-month follow-up

2003 • 79 citations

The role of dopamine in conditioning and latent inhibition: What, when, where and how?

2005 • 77 citations

Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment

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Amygdaloid Projections to Prefrontal and Motor Cortex

1977 • 65 citations

Altered forebrain neurotransmitter responses to immobilization stress following 3,4-methylenedioxymethamphetamine

2002 • 56 citations

Background Dopamine Concentration Dependently Facilitates Long-term Potentiation in Rat Prefrontal Cortex through Postsynaptic Activation of Extracellular Signal-Regulated Kinases

2009 • 54 citations

Effects of clozapine, haloperidol and iloperidone on neurotransmission and synaptic plasticity in prefrontal cortex and their accumulation in brain tissue: an in vitro study

2003 • 51 citations

Domperidone, an inhibitor of the D2-receptor, blocks a late phase of an electrically induced long-term potentiation in the CA1-region in rats.

1989 • 49 citations

Metabotropic glutamate receptors mediate expression of LTP in slices of rat visual cortex

2002 • 42 citations

The serotonergic modulation of synaptic plasticity in the rat hippocampo-medial prefrontal cortex pathway

2003 • 41 citations

Common efficacy of psychotropic drugs in restoring stress-induced impairment of prefrontal plasticity

2006 • 32 citations

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal–mPFC pathway of anesthetized rats

2008 • 29 citations

Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat

1988 • 28 citations

An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro

2003 • 20 citations

Haloperidol-induced blockade of induction of long-term potentiation in perforant path-dentate gyrus pathway in chronically prepared rabbits

1993 • 18 citations

Clozapine-induced potentiation of synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits

1996 • 15 citations

Effects of subchronic clozapine treatment on long-term potentiation in rat prefrontal cortex

2004 • 15 citations

Long-term potentiation in visual cortical projections to the medial prefrontal cortex of the rat

2003 • 15 citations