cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

1994 • 467 citations

Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine.

1979 • 444 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Sodium nitroprusside and other smooth muscle-relaxants increase cyclic GMP levels in rat ductus deferens

1977 • 422 citations

Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells.

1991 • 403 citations

Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium.

1988 • 359 citations

Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain.

1992 • 350 citations

beta-Adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles.

1983 • 348 citations

Cyclic Nucleotide-dependent Protein Kinases

1970 • 334 citations

Regulation of Intracellular Ca2+ Levels in Cultured Vascular Smooth Muscle Cells

1989 • 318 citations

Evidence for cyclic GMP-mediated relaxant effects of nitro-compounds in coronary smooth muscle

1979 • 301 citations

Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries.

1992 • 269 citations

Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP

1992 • 265 citations

Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells

1990 • 239 citations

Endothelium-induced relaxation by acetylcholine associated with larger rises in cyclic GMP in coronary arterial strips.

1982 • 228 citations

Regulation of sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells.

1991 • 226 citations

Cyclic GMP-dependent protein kinase phosphorylates phospholamban in isolated sarcoplasmic reticulum from cardiac and smooth muscle

1988 • 223 citations

Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase.

1994 • 222 citations

Effects of sodium nitroprusside, nitroglycerin, and sodium azide on levels of cyclic nucleotides and mechanical activity of various tissues.

1977 • 209 citations

The cDNA of the two isoforms of bovine cGMP‐dependent protein kinase

1989 • 195 citations

Type II regulatory subunit dimerization determines the subcellular localization of the cAMP-dependent protein kinase.

1990 • 183 citations

Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators

1989 • 166 citations

Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain

1993 • 155 citations

Mechanisms of vasodilation

1983 • 148 citations

Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.

1988 • 147 citations

Molecular cloning and predicted full‐length amino acid sequence of the type Iβ isozyme of cGMP‐dependent protein kinase from human placenta

1989 • 147 citations

Effects of 8-bromo-cGMP on Ca2+ levels in vascular smooth muscle cells: possible regulation of Ca2+-ATPase by cGMP-dependent protein kinase.

1987 • 140 citations

Antiproliferative action of cyclic GMP-elevating vasodilators in cultured rabbit aortic smooth muscle cells

1989 • 138 citations

Alpha 1-adrenergic stimulation and beta 2-adrenergic inhibition of DNA synthesis in vascular smooth muscle cells.

1990 • 134 citations

Structure and physiological role of cGMP-dependent protein kinase

1992 • 130 citations

cGMP-dependent Protein Kinase Genes in Drosophila

1989 • 129 citations

Atrial natriuretic factor inhibits proliferation of vascular smooth muscle cells stimulated by platelet-derived growth factor

1989 • 125 citations

Relationship between nitroglycerin, cyclic GMP and relaxation of vascular smooth muscle

1979 • 123 citations

Vimentin is transiently co-localized with and phosphorylated by cyclic GMP-dependent protein kinase in formyl-peptide-stimulated neutrophils.

1991 • 118 citations

Adenosine receptor‐mediated changes in cyclic AMP production and DNA synthesis in cultured arterial smooth muscle cells

1985 • 117 citations

Cell cycle-dependent inhibition of human vascular smooth muscle cell proliferation by prostaglandin E1

1985 • 115 citations

Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-CAMP but not 8-Br-cGMP

1990 • 107 citations

Peroxynitrite and atherosclerosis

1993 • 99 citations

Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta.

1988 • 86 citations

Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells.

1992 • 84 citations

Cell cycle-dependent inhibition of DNA synthesis by prostaglandin I2 in cultured rabbit aortic smooth muscle cells

1988 • 77 citations

Identification of the MAP2- and P75-binding domain in the regulatory subunit (RII beta) of type II cAMP-dependent protein kinase. Cloning and expression of the cDNA for bovine brain RII beta.

1990 • 77 citations

Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors

1992 • 76 citations

Coronary arterial relaxation and guanylate cyclase activation by cigarette smoke, N'-nitrosonornicotine and nitric oxide.

1980 • 74 citations

Cyclic GMP-dependent protein kinase in intestinal brushborders.

1981 • 72 citations

Distribution of Cyclic‐GMP‐Dependent Protein Kinase in Various Rat Tissues and Cell Lines Determined by a Sensitive and Specific Radioimmunoassay

1981 • 69 citations

Atrial natriuretic peptide-dependent phosphorylation of smooth muscle cell particulate fraction proteins is mediated by cGMP-dependent protein kinase

1989 • 66 citations

A novel biological effect of atrial natriuretic hormone: Inhibition of mesangial cell mitogenesis

1988 • 64 citations

High-Affinity Binding and Localization of the Cyclic GMP-Dependent Protein Kinase with the Intermediate Filament Protein Vimentin

1994 • 63 citations

Mechanism of atrial natriuretic factor-induced inhibition of rat mesangial cell mitogenesis.

1990 • 58 citations

Effects of nitroprusside, glyceryl trinitrate, and 8-bromo cyclic GMP on phosphorylase a formation and myosin light chain phosphorylation in rat aorta.

1985 • 53 citations

Role of phospholamban in No/EDRF-induced relaxation in rat aorta

1992 • 32 citations

Cyclic Gmp: Biochemistry, Physiology and Pathophysiology

1994 • 30 citations

Expression of the catalytic domain of cyclic GMP‐dependent protein kinase in a baculovirus system

1994 • 27 citations

Independent inhibition of DNA synthesis by protein kinase C, cyclic AMP and interferon α/β in rabbit aortic smooth muscle cells

1988 • 26 citations