Lack of C/EBP? gene expression results in increased DNA synthesis and an increased frequency of immortalization of freshly isolated mice hepatocytes

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A Laboratory manual

1989 • 6,833 citations

Liver Regeneration

1997 • 2,731 citations

Monoclonal Antibody to 5-Bromo- and 5-Iododeoxyuridine: A New Reagent for Detection of DNA Replication

1982 • 2,648 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1979 • 1,305 citations

Impaired Energy Homeostasis in C/EBPα Knockout Mice

1995 • 925 citations

CCAAT-Enhancer Binding Protein: A Component of a Differentiation Switch

1991 • 733 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.

1975 • 573 citations

Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene

1986 • 562 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

The interplay of DNA-binding proteins on the promoter of the mouse albumin gene

1987 • 532 citations

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.

1989 • 488 citations

Population expansion, clonal growth, and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF alpha in a chemically defined (HGM) medium.

1996 • 487 citations

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

1994 • 450 citations

CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

1994 • 433 citations

Calcium-Regulated Phosphorylation Within the Leucine Zipper of C/EBPβ

1992 • 398 citations

CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.

1996 • 393 citations

Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha.

1994 • 290 citations

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

1996 • 289 citations

Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

1989 • 266 citations

A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.

1988 • 239 citations

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6.

1996 • 213 citations

Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors.

1994 • 199 citations

Progress in liver diseases

1977 • 173 citations

Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin

1973 • 171 citations

Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenes.

1994 • 170 citations

Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture.

1992 • 151 citations

Participation of the transcription factor C/EBP delta in the acute-phase regulation of the human gene for complement component C3.

1993 • 136 citations

LAP (NF-IL-6), a tissue-specific transcriptional activator, is an inhibitor of hepatoma cell proliferation.

1994 • 135 citations

Expression of Liver Phenotypes in Cultured Mouse Hepatoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1980 • 134 citations

Inhibition of cell proliferation by C/EBPα occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

1995 • 133 citations

Glucose metabolism by adult hepatocytes in primary culture and by cell lines from rat liver

1978 • 86 citations

Regenerative changes in C/EBP alpha and C/EBP beta expression modulate binding to the C/EBP site in the c-fos promoter.

1994 • 84 citations

Impaired proliferation and tumorigenicity induced by CCAAT/enhancer-binding protein.

1996 • 65 citations

Selective induction of CCAAT/enhancer binding protein isoforms occurs during rat liver development

1994 • 65 citations

Glucocorticoid-Stimulated CCAAT/Enhancer-Binding Protein α Expression Is Required for Steroid-Induced G₁ Cell Cycle Arrest of Minimal-Deviation Rat Hepatoma Cells

1996 • 56 citations

Adenovirus-mediated Transfer of CCAAT/Enhancer-binding Protein-α Identifies a Dominant Antiproliferative Role for This Isoform in Hepatocytes

1996 • 51 citations

Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes.

1996 • 50 citations

Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element.

1989 • 47 citations

Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation*1

1995 • 46 citations

Coexpression of liver-specific and growth-induced genes in perinatal and regenerating liver: Attainment and maintenance of the differentiated state during rapid proliferation

1995 • 35 citations

Trans Activation of Human Alcohol Dehydrogenase Gene Expression in Hepatoma Cells by C/EBP Molecules Bound in a Novel Arrangement Just 5' and 3' to the TATA Box

1990 • 27 citations

Prospective flow cytometric DNA analysis of hepatocellular carcinoma specimens collected by ultrasound-guided fine needle aspiration

1994 • 24 citations

trans activation of human alcohol dehydrogenase gene expression in hepatoma cells by C/EBP molecules bound in a novel arrangement just 5' and 3' to the TATA box.

1990 • 18 citations

DNA binding by C/EBP proteins correlates with hepatocyte proliferation

1995 • 18 citations

The v-raf oncogene enhances tumorigenicity and suppresses differentiation in vivo in a rat hepatocyte cell line

1993 • 9 citations

Deleted Work

1955 • 0 citations