Ploidy and karyotypic alterations associated with early events in the development of hepatocarcinogenesis in transgenic mice harboring c-myc and transforming growth factor alpha transgenes.

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Constitutive Fragile Sites and Cancer

1984 • 693 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma.

1994 • 327 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Activated Oncogenes in B6C3F1 Mouse Liver Tumors: Implications for Risk Assessment

1987 • 279 citations

Genetic changes in skin tumor progression: Correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7

1990 • 270 citations

Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer.

1992 • 269 citations

Oncogene-induced liver neoplasia in transgenic mice.

1989 • 249 citations

Transgenic mouse model for synergistic effects of nuclear oncogenes and growth factors in tumorigenesis: interaction of c-myc and transforming growth factor alpha in hepatic oncogenesis.

1993 • 237 citations

Chromosome maps of man and mouse. IV

1989 • 219 citations

The analysis of malignancy by cell fusion. VII. cytogenetic analysis of hybrids between malignant and diploid cells and of tumours derived from them

1977 • 201 citations

Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma.

1989 • 191 citations

Chromosome breakage and recombination at fragile sites.

1988 • 176 citations

Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas

1988 • 161 citations

Distal deletion of chromosome Ip in ductal carcinoma of the breast.

1989 • 135 citations

Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China.

1994 • 125 citations

Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.

1991 • 124 citations

Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy.

1987 • 123 citations

Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomas.

1994 • 122 citations

Frequent Loss of Heterozygosity on Chromosomes 16 and 4 in Human Hepatocellular Carcinoma

1990 • 116 citations

Two distinct regions involved in 1p deletion in human primary breast cancer.

1993 • 101 citations

A photographic representation of the variability in the G-banded structure of the chromosomes in the mouse karyotype

1984 • 95 citations

Chromosome mapping of murine susceptibility loci to liver carcinogenesis.

1993 • 92 citations

Chromosome maps of man and mouse

1981 • 87 citations

The Initiation-Promotion-Progression Model of Rat Hepatocarcinogenesis

1993 • 82 citations

Loss of somatic heterozygosity in hepatocellular carcinoma.

1991 • 77 citations

Identification of hepatocarcinogen-resistance genes in DBA/2 mice.

1995 • 75 citations

Suppression of tumourigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region.

1993 • 75 citations

Chemical Probes and Possible Targets for the Induction of Aneuploidy

1985 • 71 citations

Fragile sites, cancer chromosome breakpoints, and oncogenes all cluster in light G bands

1988 • 69 citations

The Kinetochore of Mammalian Chromosomes: Structure and Function in Normal Mitosis and Aneuploidy

1985 • 67 citations

Rodent common fragile sites: Are they conserved? Evidence from mouse and rat

1989 • 57 citations

Loss of heterozygosity in spontaneous and chemically induced tumors of the B6C3F1 mouse

1994 • 48 citations

Chromosome Patterns in Rat Hepatocytes During <italic>N</italic>-2-Fluorenylacetamide Carcinogenesis<xref ref-type="fn" rid="FN2">2</xref>

1971 • 42 citations

Chromosome Fragility and Instability in Human Cancer

1994 • 36 citations

Multiple recurrent genomic rearrangements and fragile sites in human cancer

1987 • 36 citations

Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.

1992 • 32 citations

Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes.

1994 • 24 citations

Frequent loss of heterozygosity on chromosome 4 in diethylnitrosamine‐induced C3H/MSM mouse hepatocellular carcinomas in culture

1995 • 21 citations

Characterisation of putrescine uptake by cultured adult mouse hepatocytes

1990 • 20 citations

A method for the comparative study of replicative DNA synthesis in GGT-positive and GGT-negative hepatocytes in primary culture isolated from carcinogen-treated rats

1988 • 16 citations

Frequent deletion in chromosome 4 and duplication of chromosome 15 in liver epithelial cells derived from long‐term culture of C3H mouse hepatocytes

1994 • 15 citations

Chromosome Changes Associated With the Progression of Cell Lines From Preneoplastic to Tumorigenic Phenotype During Transformation of Mouse Salivary Gland Epithelium In Vitro

1982 • 14 citations

Specific gain of chromosome 19 in preneoplastic mouse liver cells after diethylnitrosamine treatment

1991 • 13 citations

Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic phenotypes.

1993 • 10 citations

Mitosis and the induction of aneuploidy.

1989 • 4 citations