The Long Form of the Leptin Receptor (OB-Rb) Is Widely Expressed in the Human Brain

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Identification and expression cloning of a leptin receptor, OB-R

1995 • 3,498 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

1996 • 2,185 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Cytokine signal transduction

1994 • 1,358 citations

The Leptin Receptor

1997 • 1,300 citations

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

1996 • 1,170 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Distributions of leptin receptor mRNA isoforms in the rat brain

1998 • 1,011 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Leptin: The Tale of an Obesity Gene

1996 • 987 citations

Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

1996 • 879 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues

1997 • 771 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes¹

1999 • 712 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Design and synthesis of multi-haem proteins

1994 • 550 citations

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

1997 • 506 citations

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

1997 • 374 citations

Regulation of in VivoGrowth Hormone Secretion by Leptin

1997 • 351 citations

Expression of Leptin Receptor Isoforms in Rat Brain Microvessels

1998 • 342 citations

Leptin Receptor (OB-R) Signaling

1997 • 290 citations

Leptin and Leptin Receptor Expression in Normal and Neoplastic Human Pituitary: Evidence of a Regulatory Role for Leptin on Pituitary Cell Proliferation1

1999 • 237 citations

Localization of Leptin Receptor in the Human Brain

1997 • 207 citations

Leptin Acts on Human Marrow Stromal Cells to Enhance Differentiation to Osteoblasts and to Inhibit Differentiation to Adipocytes

1999 • 187 citations

Substitution at Codon 269 (Glutamine → Proline) of the Leptin Receptor (OB-R) cDNA Is the Only Mutation Found in the Zucker Fatty (fa/fa) Rat

1996 • 186 citations

Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting.

1998 • 173 citations

Differential expression of mRNA for leptin receptor isoforms in the rat brain

1997 • 172 citations

Leptin Is a Potent Stimulator of Spontaneous Pulsatile Growth Hormone (GH) Secretion and the GH Response to GH-Releasing Hormone*

1998 • 171 citations

Localization of Leptin Receptor (Ob-R) Messenger Ribonucleic Acid in the Rodent Hindbrain*

1998 • 165 citations

Differential Expression and Regulation of Leptin Receptor Isoforms in the Rat Brain: Effects of Fasting and Oestrogen

1998 • 141 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells.

1996 • 116 citations

Role of Set‐point Theory in Regulation of Body Weight

1992 • 115 citations

Regulation of in Vivo Growth Hormone Secretion by Leptin

1997 • 104 citations

Autoradiographic Localization of Leptin Binding in the Choroid Plexus ofob/obanddb/dbMice

1996 • 102 citations

Up‐Regulation of Blood‐Brain Barrier Short‐Form Leptin Receptor Gene Products in Rats Fed a High Fat Diet

1998 • 96 citations

Leptin Is a Potent Stimulator of Spontaneous Pulsatile Growth Hormone (GH) Secretion and the GH Response to GH-Releasing Hormone

1998 • 69 citations

Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain

1997 • 53 citations

QUANTIFICATION OF THE FULL LENGTH LEPTIN RECEPTOR (OB-Rb) IN HUMAN BROWN AND WHITE ADIPOSE TISSUE

1997 • 48 citations

Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum

1997 • 47 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells

1996 • 46 citations

Liver Regeneration Is Associated with Increased Expression of the Insulin-Like Growth Factor-II/Mannose-6-Phosphate Receptor

1990 • 30 citations

Leptin Receptor Gene in a Large Cohort of Massively Obese Subjects: No Indication of the fa/fa Rat Mutation. Detection of an Intronic Variant with No Association with Obesity

1998 • 27 citations

Hypothalamic expression of neuropeptide-Y in the New Zealand obese mouse

1998 • 16 citations

Monkey Leptin Receptor mRNA: Sequence, Tissue Distribution, and mRNA Expression in the Adipose Tissue of Normal, Hyperinsulinemic, and Type 2 Diabetic Rhesus Monkeys

1998 • 13 citations