From neurobiology to treatment: progress against addiction

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Addiction and the brain: The neurobiology of compulsion and its persistence

2001 • 1,284 citations

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

2001 • 1,084 citations

Neuroscience of Addiction

1998 • 1,030 citations

Dopaminergic Modulation of Neuronal Excitability in the Striatum and Nucleus Accumbens

2000 • 916 citations

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

2000 • 869 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Stress-induced relapse to heroin and cocaine seeking in rats: a review

2000 • 695 citations

Drug-activation of brain reward pathways

1998 • 679 citations

Psychomotor stimulant addiction: a neural systems perspective.

2002 • 635 citations

Naltrexone in the Treatment of Alcohol Dependence

2001 • 610 citations

ΔFosB: A sustained molecular switch for addiction

2001 • 591 citations

Psychomotor Stimulant Addiction: A Neural Systems Perspective

2002 • 573 citations

Effective Medical Treatment of Opiate Addiction

1998 • 563 citations

Opposite Modulation of Cocaine-Seeking Behavior by D ₁ - and D ₂ -Like Dopamine Receptor Agonists

1996 • 493 citations

THALIDOMIDE AND LIMB DEFORMITIES

1962 • 461 citations

Nicotine replacement therapy for smoking cessation

2002 • 436 citations

Buprenorphine maintenance treatment of opiate dependence: a multicenter, randomized clinical trial

1998 • 414 citations

A Range of Research-Based Pharmacotherapies for Addiction

1997 • 373 citations

Time-dependent changes in extinction behavior and stress-induced reinstatement of drug seeking following withdrawal from heroin in rats

2001 • 277 citations

Methadone‐Related Opioid Agonist Pharmacotherapy for Heroin Addiction: History, Recent Molecular and Neurochemical Research and Future in Mainstream Medicine

2000 • 250 citations

The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?

2001 • 204 citations

Dopamine receptor agonists, partial agonists and psychostimulant addiction

1994 • 110 citations

Distinct Sites of Opiate Reward and Aversion within the Midbrain Identified Using a Herpes Simplex Virus Vector Expressing GluR1

2000 • 100 citations

Cocaine Sensitization and Craving

2001 • 99 citations

Time course of changes in cocaine self-administration behavior in rats during immunization with the cocaine vaccine IPC-1010

2000 • 62 citations

Effects of regulators of G protein-signaling proteins on the functional response of the mu-opioid receptor in a melanophore-based assay.

1999 • 54 citations

Immunization for prevention and treatment of cocaine abuse: legal and ethical implications1This manuscript is an expanded version of a presentation at the NIDA Symposium held during the 27th Annual Medical-Scientific Conference of the American Society of Addiction Medicine, April, 1996. The views and opinions expressed herein are those of the author and do not necessarily reflect those of the National Institute on Drug Abuse.1

1997 • 30 citations