ΔFosB: A sustained molecular switch for addiction

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Addiction, Dopamine, and the Molecular Mechanisms of Memory

2000 • 1,186 citations

Neuroscience of Addiction

1998 • 1,030 citations

Amphetamine and cocaine induce drug-specific activation of the c-fos gene in striosome-matrix compartments and limbic subdivisions of the striatum.

1990 • 958 citations

Regulation of Cocaine Reward by CREB

1998 • 762 citations

Beyond the Dopamine Receptor

1999 • 742 citations

Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine

1999 • 722 citations

Drug-activation of brain reward pathways

1998 • 679 citations

Synaptic plasticity and dynamic modulation of the postsynaptic membrane

2000 • 640 citations

Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine

1999 • 630 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments

1994 • 549 citations

Drug addiction: A model for the molecular basis of neural plasticity

1993 • 548 citations

Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors.

1991 • 499 citations

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5

2001 • 475 citations

DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission

1998 • 474 citations

Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine.

1992 • 466 citations

Postsynaptic organisation and regulation of excitatory synapses

2000 • 452 citations

The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience

1999 • 445 citations

A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity

1991 • 436 citations

LTP mechanisms: from silence to four-lane traffic

2000 • 382 citations

Common Neural Substrates for the Addictive Properties of Nicotine and Cocaine

1997 • 344 citations

Role of covalent modifications of histones in regulating gene expression

1999 • 305 citations

Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments.

1997 • 304 citations

Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system.

1995 • 291 citations

Fos B mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects

1997 • 283 citations

Network-Level Changes in Expression of Inducible Fos–Jun Proteins in the Striatum during Chronic Cocaine Treatment and Withdrawal

1996 • 274 citations

Chronic Fos-Related Antigens: Stable Variants of ΔFosB Induced in Brain by Chronic Treatments

1997 • 273 citations

Addiction to Cocaine and Amphetamine

1996 • 234 citations

Immediate-early genes: ten years on

1995 • 209 citations

Induction of chronic Fos-related antigens in rat brain by chronic morphine administration.

1996 • 206 citations

Pharmacological studies of the regulation of chronic FOS-related antigen induction by cocaine in the striatum and nucleus accumbens.

1995 • 202 citations

Transgenic Animals with Inducible, Targeted Gene Expression in Brain

1998 • 185 citations

An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.

1991 • 150 citations

Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments.

1995 • 139 citations

Essential Role of thefosB Gene in Molecular, Cellular, and Behavioral Actions of Chronic Electroconvulsive Seizures

1998 • 134 citations

Sensitization to the Behavioral Effects of Cocaine: Modulation by Dynorphin and κ-Opioid Receptor Agonists

1997 • 128 citations

Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

2000 • 105 citations

Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts.

1991 • 98 citations

Induction of Cyclin-Dependent Kinase 5 in the Hippocampus by Chronic Electroconvulsive Seizures: Role of ΔFosB

2000 • 97 citations

ΔFosB: a molecular switch underlying long-term neural plasticity

2000 • 87 citations

Opiate and Cocaine Addictions: Challenge for Pharmacotherapies

1997 • 87 citations

Neuronal and behavioural abnormalities in striatal function in DARPP‐32‐mutant mice

1999 • 81 citations

NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat

2000 • 75 citations