The New Biology of Body Weight Regulation

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

1996 • 6,254 citations

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

1995 • 4,457 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

The role of neuropeptide Y in the antiobesity action of the obese gene product

1995 • 1,521 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor

1995 • 1,469 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

1996 • 1,074 citations

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

1996 • 1,020 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Specificity of Leptin Action on Elevated Blood Glucose Levels and Hypothalamic Neuropeptide Y Gene Expression in ob/ob Mice

1996 • 873 citations

Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity

1986 • 856 citations

Insulin in the Brain: A Hormonal Regulator of Energy Balance*

1992 • 784 citations

Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.

1988 • 743 citations

Effects of parabiosis of obese with diabetes and normal mice

1973 • 728 citations

Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.

1991 • 678 citations

Altered Expression of Hypothalamic Neuropeptide mRNAs in Food-Restricted and Food-Deprived Rats

1990 • 648 citations

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

1996 • 561 citations

Inhibition of hypothalamic neuropeptide Y gene expression by insulin.

1992 • 533 citations

Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain.

1993 • 479 citations

The effects of lesions in the hypothalamus in parabiotic rats

1959 • 465 citations

Confronting the failure of behavioral and dietary treatments for obesity

1991 • 464 citations

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.

1995 • 436 citations

Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

1991 • 414 citations

Effect of Intracerebroventricular Insulin Infusion on Diabetic Hyperphagia and Hypothalamic Neuropeptide Gene Expression

1995 • 361 citations

Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse.

1993 • 276 citations

The ob Gene and Insulin: A Relationship Leading to Clues to the Understanding of Obesity

1995 • 275 citations

Central effects of CRF on metabolism and energy balance

1990 • 192 citations

Central insulin enhances sensitivity to cholecystokinin

1995 • 168 citations

Diet‐ and diabetes‐induced changes of ob gene expression in rat adipose tissue

1995 • 141 citations

OB protein binds specifically to the choroid plexus of mice and rats.

1996 • 124 citations

Intense exercise and food restriction cause similar hypothalamic neuropeptide Y increases in rats

1993 • 111 citations

Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation

1991 • 84 citations

Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding

1996 • 79 citations

Increased neuropeptide Y concentrations in specific hypothalamic regions of lactating rats: Possible relationship ot hyperphagia and adaptive changes in energy balance

1994 • 73 citations

A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents.

1995 • 58 citations