G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

2002 • 1,755 citations

Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4

1999 • 1,714 citations

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

1998 • 1,687 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.

1995 • 1,223 citations

The Biology of Hematopoietic Stem Cells

1995 • 775 citations

The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice

2000 • 760 citations

The Biology and Clinical Uses of Blood Stem Cells

1997 • 729 citations

The Chemokine Receptor CXCR4 Is Required for the Retention of B Lineage and Granulocytic Precursors within the Bone Marrow Microenvironment

1999 • 691 citations

Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1

2001 • 649 citations

Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

2000 • 606 citations

Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia

2000 • 546 citations

Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells

2001 • 530 citations

Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers

2000 • 504 citations

Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor

2001 • 493 citations

In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment

1998 • 417 citations

Shear forces promote lymphocyte migration across vascular endothelium bearing apical chemokines

2001 • 398 citations

Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival

2000 • 365 citations

Rapid and efficient homing of human CD34+CD38−/lowCXCR4+stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2mnull mice

2001 • 311 citations

Active movement of T cells away from a chemokine

2000 • 293 citations

Mobilization of Endothelial and Hematopoietic Stem and Progenitor Cells by Adenovector‐Mediated Elevation of Serum Levels of SDF‐1, VEGF, and Angiopoietin‐1

2001 • 283 citations

Interleukin-8 induces rapid mobilization of hematopoietic stem cells with radioprotective capacity and long-term myelolymphoid repopulating ability

1995 • 274 citations

Kinetic Investigation of Chemokine Truncation by CD26/Dipeptidyl Peptidase IV Reveals a Striking Selectivity within the Chemokine Family

2001 • 273 citations

Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation

2000 • 267 citations

Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the Metalloproteinase gelatinase B (MMP-9)

1999 • 241 citations

A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution

1999 • 233 citations

Anti–VLA4/VCAM-1—Induced Mobilization Requires Cooperative Signaling Through the kit/mkit Ligand Pathway

1998 • 228 citations

Growth Factors and Cytokines Upregulate Gelatinase Expression in Bone Marrow CD34+ Cells and Their Transmigration Through Reconstituted Basement Membrane

1999 • 222 citations

Leukocyte Elastase Negatively Regulates Stromal Cell-derived Factor-1 (SDF-1)/CXCR4 Binding and Functions by Amino-terminal Processing of SDF-1 and CXCR4

2002 • 219 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells.

2002 • 212 citations

Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α

1998 • 194 citations

The Unexpected G0/G1 Cell Cycle Status of Mobilized Hematopoietic Stem Cells From Peripheral Blood

1997 • 191 citations

Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells

2002 • 185 citations

Differential MMP and TIMP production by human marrow and peripheral blood CD34+ cells in response to chemokines

2000 • 182 citations

CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells

2001 • 165 citations

Proteolytic Cleavage of ICAM-1 by Human Neutrophil Elastase

1998 • 164 citations

Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis.

1998 • 162 citations

Rapid inactivation of stromal cell-derived factor-1 by cathepsin G associated with lymphocytes

2001 • 157 citations

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice

2002 • 139 citations

Stromal Cell-Derived Factor-1α and Stem Cell Factor/kit Ligand Share Signaling Pathways in Hemopoietic Progenitors: A Potential Mechanism for Cooperative Induction of Chemotaxis

1998 • 137 citations

Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells

2000 • 131 citations

The Granulocyte Colony-Stimulating Factor Receptor Is Required for the Mobilization of Murine Hematopoietic Progenitors Into Peripheral Blood by Cyclophosphamide or Interleukin-8 But Not Flt-3 Ligand

1997 • 127 citations

Noncycling state of peripheral blood progenitor cells mobilized by granulocyte colony-stimulating factor and other cytokines

1995 • 124 citations

Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms

2000 • 124 citations

Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) Mouse as a Model System to Study the Engraftment and Mobilization of Human Peripheral Blood Stem Cells

1998 • 123 citations

In vitro migratory capacity of CD34+ cells is related to hematopoietic recovery after autologous stem cell transplantation

2001 • 120 citations

Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis: Expression of SDF-1 by mesothelial cells and biliary ductal plate epithelial cells

1999 • 109 citations

Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140

2001 • 108 citations

Phenotypic heterogeneity among stromal cell lines from mouse bone marrow disclosed in their extracellular matrix composition and interactions with normal and leukemic cells

1985 • 104 citations

IL-4 and a glucocorticoid up-regulate CXCR4 expression on human CD4+ T lymphocytes and enhance HIV-1 replication

1998 • 97 citations

Nonobese Diabetic/Severe Combined Immunodeficiency (NOD/SCID) Mouse as a Model System to Study the Engraftment and Mobilization of Human Peripheral Blood Stem Cells

1998 • 97 citations

Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence

2000 • 95 citations

Human Mast Cells Transmigrate Through Human Umbilical Vein Endothelial Monolayers and Selectively Produce IL-8 in Response to Stromal Cell-Derived Factor-1α

2000 • 90 citations

Plasma Levels of SDF-1 and Expression of SDF-1 Receptor on CD34+ Cells in Mobilized Peripheral Blood of Non-Hodgkin's Lymphoma Patients

2001 • 75 citations

Endogenous Interleukin-8 (IL-8) Surge in Granulocyte Colony-Stimulating Factor–Induced Peripheral Blood Stem Cell Mobilization

1999 • 75 citations

Expression of Adhesion Molecules and c-kit on CD34⁺Hematopoietic Progenitor Cells: Comparison of Cytokine-Mobilized Blood Stem Cells with Normal Bone Marrow and Peripheral Blood

1993 • 74 citations

Association between the SDF1‐3′A allele and high levels of CD34⁺ progenitor cells mobilized into peripheral blood in humans

2001 • 71 citations

Mechanisms of granulocyte colony-stimulating factor-induced hematopoietic progenitor-cell mobilization

2000 • 66 citations

CXC chemokine receptor 4 expression and stromal cell‐derived factor‐1α‐induced chemotaxis in CD4⁺ T lymphocytes are regulated by interleukin‐4 and interleukin‐10

2000 • 51 citations

Immunologic Profiles of Effector Cells and Peripheral Blood Stem Cells Mobilized with Different Hematopoietic Growth Factors

2000 • 43 citations

Correlation between Circulating Stromal Cell-Derived Factor 1 Levels and CD4+ Cell Count in Human Immunodeficiency Virus Type 1-Infected Individuals

1999 • 36 citations