Thymidine phosphorylase expression results in a decrease in apoptosis and increase in intratumoral microvessel density in human gastric carcinomas

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis.

1995 • 578 citations

Thymidine phosphorylase is angiogenic and promotes tumor growth.

1995 • 394 citations

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

1996 • 367 citations

Purine nucleoside synthesis: an efficient method employing nucleoside phosphorylases

1981 • 191 citations

The activity and expression of thymidine phosphorylase in human solid tumours

1996 • 182 citations

Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

1995 • 164 citations

Thymidine Phosphorylase Activity Associated with Platelet-Derived Endothelial Cell Growth Factor1

1993 • 144 citations

Kinetic studies of thymidine phosphorylase from mouse liver

1985 • 131 citations

Prevention of Hypoxia-Induced Apoptosis by the Angiogenic Factor Thymidine Phosphorylase

1998 • 112 citations

Correlation between thymidine phosphorylase expression and prognosis in human renal cell carcinoma.

1997 • 105 citations

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma

1996 • 104 citations

Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma.

1997 • 97 citations

Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas.

1999 • 86 citations

Combined analysis of vascular endothelial growth factor and platelet-derived endothelial cell growth factor expression in gastric carcinoma

1997 • 73 citations

Pentosyl Transfer Mechanisms of the Mammalian Nucleoside Phosphorylases

1968 • 71 citations

Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas.

1998 • 62 citations

Platelet-derived endothelial cell growth factor (Thymidine Phosphorylase) expression in lung cancer

1997 • 56 citations

Pyrimidine nucleotide metabolism in human colon carcinomas: Comparison of normal tissues, primary tumors and xenografts

1994 • 44 citations

Tumor angiogenesis and expression of thymidine phosphorylase/ platelet derived endothelial cell growth factor in human gastric carcinoma

1996 • 40 citations

Thymidine phosphorylase activity in human bladder cancer: difference between superficial and invasive cancer.

1997 • 38 citations

Evidence that Expression of a Mutated p53 Gene Attenuates Apoptotic Cell Death in Human Gastric Intestinal‐type Carcinomas in vivo

1997 • 29 citations

Thymidine phosphorylase expression in human colorectal mucosa, adenoma and carcinoma: Role of p53 expression

1999 • 24 citations

Antitumor activity of 5'-deoxy-5-fluorouridine in human digestive organ cancer xenografts and pyrimidine nucleoside phosphorylase activity in normal and neoplastic tissues from human digestive organs.

1992 • 17 citations

The expression of thymidine phosphorylase/platelet‐derived endothelial cell growth factor is correlated to angiogenesis in breast cancer

1998 • 16 citations

Clinical significance of pyrimidine nucleoside phosphorylase in colorectal carcinoma

1997 • 9 citations