Thymidine phosphorylase expression is associated with both increase of intratumoral microvessels and decrease of apoptosis in human colorectal carcinomas.

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1989 • 726 citations

Thymidine phosphorylase is angiogenic and promotes tumor growth.

1995 • 394 citations

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

1996 • 367 citations

Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.

1996 • 349 citations

Different angiogenic pathways characterize superficial and invasive bladder cancer.

1995 • 293 citations

Platelet‐derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: An immunohistochemical study

1995 • 192 citations

Purine nucleoside synthesis: an efficient method employing nucleoside phosphorylases

1981 • 191 citations

The activity and expression of thymidine phosphorylase in human solid tumours

1996 • 182 citations

Expression of platelet‐derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer

1995 • 164 citations

Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma

1996 • 159 citations

Thymidine Phosphorylase Activity Associated with Platelet-Derived Endothelial Cell Growth Factor1

1993 • 144 citations

Deoxyribosyl Transfer

1964 • 139 citations

Kinetic studies of thymidine phosphorylase from mouse liver

1985 • 131 citations

Expression of Thymidine Phosphorylase in Human Gastric Carcinoma

1996 • 104 citations

Spontaneous apoptosis is inversely related to intratumoral microvessel density in gastric carcinoma.

1997 • 97 citations

Apoptosis in Human Adenocarcinoma HT29 Cells Induced by Exposure to Hypoxia

1995 • 95 citations

Changes of angiogenesis and tumor cell apoptosis during colorectal carcinogenesis.

1999 • 92 citations

Apoptosis occurs more frequently in metastatic foci than in primary lesions of human colorectal carcinomas: Analysis by terminal-deoxynucleotidyl-transferase-mediated dUTP-biotin nick end labeling

1996 • 72 citations

Pentosyl Transfer Mechanisms of the Mammalian Nucleoside Phosphorylases

1968 • 71 citations

Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas.

1998 • 62 citations

Apoptosis in substantia nigra following developmental hypoxic-ischemic injury

1995 • 61 citations

The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas

1995 • 49 citations

Hypoxia-Induced Apoptosis in Human Cells with Normal p53 Status and Function, without Any Alteration in the Nuclear Protein Level

1997 • 38 citations

S-phase accumulation precedes apoptosis induced by preoperative treatment with 5-fluorouracil in human colorectal carcinoma cells

1999 • 29 citations

Evidence that Expression of a Mutated p53 Gene Attenuates Apoptotic Cell Death in Human Gastric Intestinal‐type Carcinomas in vivo

1997 • 29 citations

Comparative Study of p53 Expression in Primary Invasive Ductal Carcinoma of the Pancreas Between Chinese and Japanese

1998 • 17 citations

The expression of thymidine phosphorylase/platelet‐derived endothelial cell growth factor is correlated to angiogenesis in breast cancer

1998 • 16 citations